1 to 9 of 9 literature results

• Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance.

  BACKGROUND & AIMS: Little is known about the role of mitochondrial beta-oxidation in development of nonalcoholic fatty liver disease (NAFLD). Mitochon…

  Authors: Jamal A Ibdah, Peter Perlegas, Yiwen Zhao, Jerry Angdisen, Hermina Borgerink, Melanie K Shadoan, Janice D Wagner, Dietrich Matern, Piero Rinaldo, J Mark Cline

  Source: Gastroenterology. 2005 May

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• Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.

  The prevalence of diabetes throughout the world continues to increase and has become a major health issue. Recently there have been several reports of…

  Authors: Nicole C Goodwin, Ross Mabon, Bryce A Harrison, Melanie K Shadoan, Zheng Y Almstead, Yiling Xie, Jason Healy, Lindsey M Buhring, Christopher M DaCosta, Jennifer Bardenhagen,…

  Source: Journal of medicinal chemistry. 2009 Oct 22

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• Effects of hormone therapy on insulin signaling proteins in skeletal muscle of cynomolgus monkeys.

  We have previously shown that hormone therapy (HT) with medroxyprogesterone acetate (MPA) alone or in combination with conjugated equine estrogens (CE…

  Authors: Melanie K Shadoan, Li Zhang, Janice D Wagner

  Source: Steroids. 2004 May

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• High isoflavone soy diet increases insulin secretion without decreasing insulin sensitivity in premenopausal nonhuman primates.

  Consuming soy and soy isoflavones has been shown to cause modest improvements in plasma lipids, lipoproteins, and indices of insulin sensitivity in po…

  Authors: Kylie Kavanagh, Kate L Jones, Li Zhang, David M Flynn, Melanie K Shadoan, Janice D Wagner

  Source: Nutrition research (New York, N.Y.). 2008 Jun

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• Addition of medroxyprogesterone acetate to conjugated equine estrogens results in insulin resistance in adipose tissue.

  The purpose of this study was to determine if the insulin resistance we have previously reported in surgically postmenopausal primates treated with co…

  Authors: Melanie K Shadoan, Kylie Kavanagh, Li Zhang, Mary S Anthony, Janice D Wagner

  Source: Metabolism: clinical and experimental. 2007 Jun

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• Effects of soy protein and isoflavones on insulin resistance and adiponectin in male monkeys.

  Isoflavones may influence insulin action by means of their well-known receptor-mediated estrogenic activity. However, isoflavones also bind to peroxis…

  Authors: Janice D Wagner, Li Zhang, Melanie K Shadoan, Kylie Kavanagh, Haiying Chen, Kristianti Tresnasari, Jay R Kaplan, Michael R Adams

  Source: Metabolism: clinical and experimental. 2008 Jul

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• Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion.

  The Slc30a8 gene encodes the islet-specific zinc transporter ZnT-8, which provides zinc for insulin-hexamer formation. Polymorphic variants in amino a…

  Authors: Lynley D Pound, Suparna A Sarkar, Richard K P Benninger, Yingda Wang, Adisak Suwanichkul, Melanie K Shadoan, Richard L Printz, James K Oeser, Catherine E Lee, David W Piston,…

  Source: The Biochemical journal. 2009 Aug 1

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• Effects of tibolone and conjugated equine estrogens with or without medroxyprogesterone acetate on body composition and fasting carbohydrate measures in surgically postmenopausal monkeys.

  The effects of tibolone on body weight, body composition, and fasting carbohydrate measures in surgically postmenopausal cynomolgus monkeys were compa…

  Authors: Melanie K Shadoan, Mary S Anthony, Samuel E Rankin, Thomas B Clarkson, Janice D Wagner

  Source: Metabolism: clinical and experimental. 2003 Sep

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• Soy protein with isoflavones, but not an isoflavone-rich supplement, improves arterial low-density lipoprotein metabolism and atherogenesis.

  OBJECTIVE: We sought to determine if arterial LDL metabolism contributes to the decreased atherosclerosis seen with soy and if isolated isoflavones wo…

  Authors: Janice D Wagner, Dawn C Schwenke, Kathryn A Greaves, Li Zhang, Mary S Anthony, Robert M Blair, Melanie K Shadoan, J Koudy Williams

  Source: Arteriosclerosis, thrombosis, and vascular biology. 2003 Dec

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