1 to 3 of 3 literature results

• Imatinib resistance and progression of CML to blast crisis: somatic hypermutation AIDing the way.

  Very little is known about how acquired oncogenic mutations arise. In this issue of Cancer Cell, Klemm and colleagues present evidence supporting a ro…

  Authors: Matthew P Strout, David G Schatz

  Source: Cancer cell. 2009 Sep 8

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• The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy.

  MLL (ALL-1) chimeric fusions and MLL partial tandem duplications (PTD) may have mechanistically distinct contributions to leukemogenesis. Acute myeloi…

  Authors: Susan P Whitman, Shujun Liu, Tamara Vukosavljevic, Laura J Rush, Li Yu, Chunhui Liu, Marko I Klisovic, Kati Maharry, Martin Guimond, Matthew P Strout,…

  Source: Blood. 2005 Jul 1

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• Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations.

  We previously identified a rearrangement of mixed-lineage leukemia (MLL) gene (also known as ALL-1, HRX, and HTRX1), consisting of an in-frame partial…

  Authors: Adrienne M Dorrance, Shujun Liu, Weifeng Yuan, Brian Becknell, Kristy J Arnoczky, Martin Guimond, Matthew P Strout, Lan Feng, Tatsuya Nakamura, Li Yu,…

  Source: The Journal of clinical investigation. 2006 Oct

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