1 to 10 of 29 literature results

• A survey of genetic human cortical gene expression.

  It is widely assumed that genetic differences in gene expression underpin much of the difference among individuals and many of the quantitative traits…

  Authors: Amanda J Myers, J Raphael Gibbs, Jennifer A Webster, Kristen Rohrer, Alice Zhao, Lauren Marlowe, Mona Kaleem, Doris Leung, Leslie Bryden, Priti Nath,…

  Source: Nature genetics. 2007 Dec

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• A genome-wide analysis identifies genetic variants in the RELN gene associated with otosclerosis.

  Otosclerosis is a common form of progressive hearing loss, characterized by abnormal bone remodeling in the otic capsule. The etiology of the disease …

  Authors: Isabelle Schrauwen, Megan Ealy, Matthew J Huentelman, Melissa Thys, Nils Homer, Kathleen Vanderstraeten, Erik Fransen, Jason J Corneveaux, David W Craig, Mireille Claustres,…

  Source: American journal of human genetics. 2009 Mar

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• Genetic control of human brain transcript expression in Alzheimer disease.

  We recently surveyed the relationship between the human brain transcriptome and genome in a series of neuropathologically normal postmortem samples. W…

  Authors: Jennifer A Webster, J Raphael Gibbs, Jennifer Clarke, Monika Ray, Weixiong Zhang, Peter Holmans, Kristen Rohrer, Alice Zhao, Lauren Marlowe, Mona Kaleem,…

  Source: American journal of human genetics. 2009 Apr

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• Calmodulin-binding transcription activator 1 (CAMTA1) alleles predispose human episodic memory performance.

  Little is known about the genes and proteins involved in the process of human memory. To identify genetic factors related to human episodic memory per…

  Authors: Matthew J Huentelman, Andreas Papassotiropoulos, David W Craig, Frederic J Hoerndli, John V Pearson, Kim-Dung Huynh, Jason Corneveaux, Jürgen Hänggi, Christian R A Mondadori, Andreas Buchmann,…

  Source: Human molecular genetics. 2007 Jun 15

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• GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers.

  The apolipoprotein E (APOE) epsilon4 allele is the best established genetic risk factor for late-onset Alzheimer's disease (LOAD). We conducted genome…

  Authors: Eric M Reiman, Jennifer A Webster, Amanda J Myers, John Hardy, Travis Dunckley, Victoria L Zismann, Keta D Joshipura, John V Pearson, Diane Hu-Lince, Matthew J Huentelman,…

  Source: Neuron. 2007 Jun 7

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• Identification of the genetic basis for complex disorders by use of pooling-based genomewide single-nucleotide-polymorphism association studies.

  We report the development and validation of experimental methods, study designs, and analysis software for pooling-based genomewide association (GWA) …

  Authors: John V Pearson, Matthew J Huentelman, Rebecca F Halperin, Waibhav D Tembe, Stacey Melquist, Nils Homer, Marcel Brun, Szabolcs Szelinger, Keith D Coon, Victoria L Zismann,…

  Source: American journal of human genetics. 2007 Jan

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• Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan of 500,288 single-nucleotide polymorphisms.

  To date, only the H1 MAPT haplotype has been consistently associated with risk of developing the neurodegenerative disease progressive supranuclear pa…

  Authors: Stacey Melquist, David W Craig, Matthew J Huentelman, Richard Crook, John V Pearson, Matt Baker, Victoria L Zismann, Jennifer Gass, Jennifer Adamson, Szabolcs Szelinger,…

  Source: American journal of human genetics. 2007 Apr

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• GRM7 variants confer susceptibility to age-related hearing impairment.

  Age-related hearing impairment (ARHI), or presbycusis, is the most prevalent sensory impairment in the elderly. ARHI is a complex disease caused by an…

  Authors: Rick A Friedman, Lut Van Laer, Matthew J Huentelman, Sonal S Sheth, Els Van Eyken, Jason J Corneveaux, Waibhav D Tembe, Rebecca F Halperin, Ashley Q Thorburn, Sofie Thys,…

  Source: Human molecular genetics. 2009 Feb 15

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• Hippocampal gene expression changes during age-related cognitive decline.

  As humans age, cognitive performance decreases differentially across individuals. This age-related decline in otherwise healthy individuals is likely …

  Authors: Traci L Pawlowski, Linda L Bellush, Amy W Wright, Jon P Walker, Robert A Colvin, Matthew J Huentelman

  Source: Brain research. 2009 Feb 23

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• Peripheral delivery of a ROCK inhibitor improves learning and working memory.

  Previously, utilizing a series of genome-wide association, brain imaging, and gene expression studies we implicated the KIBRA gene and the RhoA/ROCK p…

  Authors: Matthew J Huentelman, Dietrich A Stephan, Joshua Talboom, Jason J Corneveaux, David M Reiman, Jill D Gerber, Carol A Barnes, Gene E Alexander, Eric M Reiman, Heather A Bimonte-Nelson

  Source: Behavioral neuroscience. 2009 Feb

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