1 to 10 of 13 literature results

• Genesis and regulation of the heart automaticity.

  The heart automaticity is a fundamental physiological function in higher organisms. The spontaneous activity is initiated by specialized populations o…

  Authors: Matteo E Mangoni, Joël Nargeot

  Source: Physiological reviews. 2008 Jul

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• Connexin 30 is expressed in the mouse sino-atrial node and modulates heart rate.

  AIMS: This study aimed at characterizing expression and the functional role of the Gjb6 gene, encoding for connexin 30 (Cx30) protein, in the adult mo…

  Authors: Daniel Gros, Magali Théveniau-Ruissy, Monique Bernard, Thierry Calmels, Frank Kober, Goran Söhl, Klaus Willecke, Joël Nargeot, Habo J Jongsma, Matteo E Mangoni

  Source: Cardiovascular research. 2010 Jan 1

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• Identification of potential pharmacological targets by analysis of the comprehensive G protein-coupled receptor repertoire in the four cardiac chambers.

  Cardiac function is regulated by many hormones and neurotransmitters that exert their physiological effects through the activation of G protein-couple…

  Authors: Thomas Moore-Morris, Annie Varrault, Matteo E Mangoni, Anne Le Digarcher, Vincent Negre, Christelle Dantec, Laurent Journot, Joel Nargeot, Brigitte Couette

  Source: Molecular pharmacology. 2009 May

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• Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1/alpha1G T-type calcium channels.

  The generation of the mammalian heartbeat is a complex and vital function requiring multiple and coordinated ionic channel activities. The functional …

  Authors: Matteo E Mangoni, Achraf Traboulsie, Anne-Laure Leoni, Brigitte Couette, Laurine Marger, Khai Le Quang, Elodie Kupfer, Anne Cohen-Solal, José Vilar, Hee-Sup Shin,…

  Source: Circulation research. 2006 Jun 9

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• Nkx2.5 cell-autonomous gene function is required for the postnatal formation of the peripheral ventricular conduction system.

  The ventricular conduction system is responsible for rapid propagation of electrical activity to coordinate ventricular contraction. To investigate th…

  Authors: Sonia Meysen, Laurine Marger, Kenneth W Hewett, Thérèse Jarry-Guichard, Irina Agarkova, Jean Paul Chauvin, Jean Claude Perriard, Seigo Izumo, Robert G Gourdie, Matteo E Mangoni,…

  Source: Developmental biology. 2007 Mar 15

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• Chronic heart rate reduction remodels ion channel transcripts in the mouse sinoatrial node but not in the ventricle.

  We investigated the effects of chronic and moderate heart rate (HR) reduction on ion channel expression in the mouse sinoatrial node (SAN) and ventric…

  Authors: Anne-Laure Leoni, Céline Marionneau, Sophie Demolombe, Sabrina Le Bouter, Matteo E Mangoni, Denis Escande, Flavien Charpentier

  Source: Physiological genomics. 2005 Dec 14

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• Adenosine receptors, heart rate, and cardioprotection.

  Authors: Matteo E Mangoni, Stéphanie Barrère-Lemaire

  Source: Cardiovascular research. 2004 Jun 1

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• Control of heart rate by cAMP sensitivity of HCN channels.

  Pacemaker" f-channels mediating the hyperpolarization-activated nonselective cation current I(f) are directly regulated by cAMP. Accordingly, the acti…

  Authors: Jacqueline Alig, Laurine Marger, Pietro Mesirca, Heimo Ehmke, Matteo E Mangoni, Dirk Isbrandt

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2009 Jul 21

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• Voltage-dependent calcium channels and cardiac pacemaker activity: from ionic currents to genes.

  The spontaneous activity of pacemaker cells in the sino-atrial node controls the heart rhythm and rate under physiological conditions. Compared to wor…

  Authors: Matteo E Mangoni, Brigitte Couette, Laurine Marger, Emmanuel Bourinet, Jörg Striessnig, Joël Nargeot

  Source: Progress in biophysics and molecular biology. 2006 Jan-Apr

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• Dissecting the functional role of different isoforms of the L-type Ca2+ channel.

  There currently exist a great number of different mouse lines in which the activity of a particular gene of interest has been inactivated or enhanced.…

  Authors: Emmanuel Bourinet, Matteo E Mangoni, Joël Nargeot

  Source: The Journal of clinical investigation. 2004 May

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