1 to 10 of 184 literature results

• The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-kappaB and activate T cells.

  In addition to ligation of the T cell antigen receptor (TCR), activation of the CD28 coreceptor by the costimulatory molecule B7 is required for induc…

  Authors: Sung-Gyoo Park, Jan Schulze-Luehrman, Matthew S Hayden, Naoko Hashimoto, Wataru Ogawa, Masato Kasuga, Sankar Ghosh

  Source: Nature immunology. 2009 Feb

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• Neuroepithelial cells supply an initial transient wave of MSC differentiation.

  Mesenchymal stem cells (MSCs) are defined as cells that undergo sustained in vitro growth and are able to give rise to multiple mesenchymal lineages. …

  Authors: Yasuhiro Takashima, Takumi Era, Kazuki Nakao, Saki Kondo, Masato Kasuga, Austin G Smith, Shin-Ichi Nishikawa

  Source: Cell. 2007 Jun 29

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• Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation.

  Insulin receptor substrate (IRS)-1 and IRS-2 have dominant roles in the action of insulin, but other substrates of the insulin receptor kinase, such a…

  Authors: Tetsuya Hosooka, Tetsuya Noguchi, Ko Kotani, Takehiro Nakamura, Hiroshi Sakaue, Hiroshi Inoue, Wataru Ogawa, Kazutoshi Tobimatsu, Kazuo Takazawa, Mashito Sakai,…

  Source: Nature medicine. 2008 Feb

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• Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice.

  The protein p27(Kip1) regulates cell cycle progression in mammals by inhibiting the activity of cyclin-dependent kinases (CDKs). Here we show that p27…

  Authors: Tohru Uchida, Takehiro Nakamura, Naoko Hashimoto, Tomokazu Matsuda, Ko Kotani, Hiroshi Sakaue, Yoshiaki Kido, Yoshitake Hayashi, Keiichi I Nakayama, Morris F White,…

  Source: Nature medicine. 2005 Feb

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• Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass.

  The total mass of islets of Langerhans is reduced in individuals with type 2 diabetes, possibly contributing to the pathogenesis of this condition. Al…

  Authors: Naoko Hashimoto, Yoshiaki Kido, Tohru Uchida, Shun-ichiro Asahara, Yutaka Shigeyama, Tomokazu Matsuda, Akihiko Takeda, Daisuke Tsuchihashi, Akihiko Nishizawa, Wataru Ogawa,…

  Source: Nature genetics. 2006 May

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• Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus.

  Recent advances in genome research have enabled the identification of new genomic variations that are associated with type 2 diabetes mellitus (T2DM).…

  Authors: Koji Okamoto, Naoko Iwasaki, Chisa Nishimura, Kent Doi, Eisei Noiri, Shinko Nakamura, Miho Takizawa, Makiko Ogata, Risa Fujimaki, Niels Grarup,…

  Source: American journal of human genetics. 2010 Jan

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• An increase in the circulating concentration of monocyte chemoattractant protein-1 elicits systemic insulin resistance irrespective of adipose tissue inflammation in mice.

  Chronic inflammation in adipose tissue is thought to be important for the development of insulin resistance in obesity. Furthermore, the level of mono…

  Authors: Sanshiro Tateya, Yoshikazu Tamori, Takayuki Kawaguchi, Hajime Kanda, Masato Kasuga

  Source: Endocrinology. 2010 Mar

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• RBP4, an unexpected adipokine.

  Authors: Yoshikazu Tamori, Hiroshi Sakaue, Masato Kasuga

  Source: Nature medicine. 2006 Jan

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• Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.

  We carried out a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, with a total of 1,612 cases and 1,424 c…

  Authors: Kazuki Yasuda, Kazuaki Miyake, Yukio Horikawa, Kazuo Hara, Haruhiko Osawa, Hiroto Furuta, Yushi Hirota, Hiroyuki Mori, Anna Jonsson, Yoshifumi Sato,…

  Source: Nature genetics. 2008 Sep

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• Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo.

  The transcription factor, signal transducer and activator of transcription-3 (STAT-3) contributes to various physiological processes. Here we show tha…

  Authors: Hiroshi Inoue, Wataru Ogawa, Michitaka Ozaki, Sanae Haga, Michihiro Matsumoto, Kensuke Furukawa, Naoko Hashimoto, Yoshiaki Kido, Toshiyuki Mori, Hiroshi Sakaue,…

  Source: Nature medicine. 2004 Feb

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