1 to 10 of 12 literature results

• The kallikrein-kinin system in health and in diseases of the kidney.

  Since kallikrein was discovered as a vasodilatory substance in human urine, the kallikrein-kinin system (KKS) has been considered to play a physiologi…

  Authors: Masao Kakoki, Oliver Smithies

  Source: Kidney international. 2009 May

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• Altering the expression in mice of genes by modifying their 3' regions.

  Polymorphic differences altering expression of genes without changing their products probably underlie human quantitative traits affecting risks of se…

  Authors: Masao Kakoki, Yau-Sheng Tsai, Hyung-Suk Kim, Seigo Hatada, Dominic J Ciavatta, Nobuyuki Takahashi, Larry W Arnold, Nobuyo Maeda, Oliver Smithies

  Source: Developmental cell. 2004 Apr

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• Quantitative effects of common genetic variations in the 3'UTR of the human LDL-receptor gene and their associations with plasma lipid levels in the Atherosclerosis Risk in Communities study.

  The low-density lipoprotein receptor (LDLR) plays a pivotal role in cholesterol homeostasis. However, the role of genetic variations in the 3'UTR of t…

  Authors: Hind Muallem, Kari E North, Masao Kakoki, Mary K Wojczynski, Xia Li, Megan Grove, Eric Boerwinkle, Kirk C Wilhelmsen, Gerardo Heiss, Nobuyo Maeda

  Source: Human genetics. 2007 May

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• Cationic amino acid transport in the renal medulla and blood pressure regulation.

  Previous studies have indicated that NO synthesis in isolated inner medullary collecting duct cells is reduced by cationic amino acids that compete wi…

  Authors: Masao Kakoki, Weili Wang, David L Mattson

  Source: Hypertension. 2002 Feb

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• Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury: studies on transgenic/knockout mice of adrenomedullin gene.

  Adrenomedullin (AM) is a potent depressor peptide whose vascular action is suggested to involve nitric oxide (NO) release. To explore the role of endo…

  Authors: Hiroaki Nishimatsu, Yasunobu Hirata, Takayuki Shindo, Hiroki Kurihara, Masao Kakoki, Daisuke Nagata, Hiroshi Hayakawa, Hiroshi Satonaka, Masataka Sata, Akihiro Tojo,…

  Source: Circulation research. 2002 Apr 5

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• Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury.

  To explore the role of the kallikrein-kinin system in relation to ischemia/reperfusion injury in the kidney, we generated mice lacking both the bradyk…

  Authors: Masao Kakoki, Robert W McGarrah, Hyung-Suk Kim, Oliver Smithies

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2007 May 1

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• Amino acids as modulators of endothelium-derived nitric oxide.

  To examine the mechanisms whereby amino acids modulate nitric oxide (NO) production and blood flow in the renal vasculature, chemiluminescence techniq…

  Authors: Masao Kakoki, Hyung-Suk Kim, Cora-Jean S Edgell, Nobuyo Maeda, Oliver Smithies, David L Mattson

  Source: American journal of physiology. Renal physiology. 2006 Aug

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• Mouse models of diabetic nephropathy.

  Diabetic nephropathy is a major cause of ESRD worldwide. Despite its prevalence, a lack of reliable animal models that mimic human disease has delayed…

  Authors: Frank C Brosius, Charles E Alpers, Erwin P Bottinger, Matthew D Breyer, Thomas M Coffman, Susan B Gurley, Raymond C Harris, Masao Kakoki, Matthias Kretzler, Edward H Leiter,…

  Source: Journal of the American Society of Nephrology : JASN. 2009 Dec

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• Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor.

  Type I human diabetics and streptozotocin-induced diabetic mice with higher genetically determined levels of angiotensin-converting enzyme have an inc…

  Authors: Masao Kakoki, Nobuyuki Takahashi, J Charles Jennette, Oliver Smithies

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2004 Sep 7

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• L-Arginine uptake affects nitric oxide production and blood flow in the renal medulla.

  Experiments were performed to determine whether L-arginine transport regulates nitric oxide (NO) production and hemodynamics in the renal medulla. The…

  Authors: Masao Kakoki, Hyung-Suk Kim, William J Arendshorst, David L Mattson

  Source: American journal of physiology. Regulatory, integrative and comparative physiology. 2004 Dec

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