10 literature results

• Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells.

  Integrin activation is essential for the function of all blood cells, including platelets and leukocytes. The blood cell-specific FERM domain protein …

  Authors: Markus Moser, Martina Bauer, Stephan Schmid, Raphael Ruppert, Sarah Schmidt, Michael Sixt, Hao-Ven Wang, Markus Sperandio, Reinhard Fässler

  Source: Nature medicine. 2009 Mar

  View Full Text

• Beta1 integrins: zip codes and signaling relay for blood cells.

  At least eight of the twelve known members of the beta1 integrin family are expressed on hematopoietic cells. Among these, the VCAM-1 receptor alpha4b…

  Authors: Michael Sixt, Martina Bauer, Tim Lämmermann, Reinhard Fässler

  Source: Current opinion in cell biology. 2006 Oct

  View Full Text

• Adult murine hematopoiesis can proceed without beta1 and beta7 integrins.

  The function of alpha4beta1 and alpha4beta7 integrins in hematopoiesis is controversial. While some experimental evidence suggests a crucial role for …

  Authors: Gerd Bungartz, Sebastian Stiller, Martina Bauer, Werner Müller, Angela Schippers, Norbert Wagner, Reinhard Fässler, Cord Brakebusch

  Source: Blood. 2006 Sep 15

  View Full Text

• Overlapping activator sequences determined for two oppositely oriented promoters in halophilic Archaea.

  Transcription of the genomic region involved in gas vesicle formation in Halobacterium salinarum (p-vac) and Haloferax mediterranei (mc-vac) is driven…

  Authors: Martina Bauer, Larissa Marschaus, Muriel Reuff, Verena Besche, Simone Sartorius-Neef, Felicitas Pfeifer

  Source: Nucleic acids research. 2008 Feb

  View Full Text

• RhoH is important for positive thymocyte selection and T-cell receptor signaling.

  RhoH is a small GTPase expressed only in the hematopoietic system. With the use of mice with targeted disruption of the RhoH gene, we demonstrated tha…

  Authors: Tatjana Dorn, Ursula Kuhn, Gerd Bungartz, Sebastian Stiller, Martina Bauer, Joachim Ellwart, Thorsten Peters, Karin Scharffetter-Kochanek, Monika Semmrich, Melanie Laschinger,…

  Source: Blood. 2007 Mar 15

  View Full Text

• Dysfunction of endocytic and autophagic pathways in a lysosomal storage disease.

  OBJECTIVE: To understand the mechanisms of skeletal muscle destruction and resistance to enzyme replacement therapy in Pompe disease, a deficiency of …

  Authors: Tokiko Fukuda, Lindsay Ewan, Martina Bauer, Robert J Mattaliano, Kristien Zaal, Evelyn Ralston, Paul H Plotz, Nina Raben

  Source: Annals of neurology. 2006 Apr

  View Full Text

• Analysis of integrin functions in peri-implantation embryos, hematopoietic system, and skin.

  Integrins mediate cell adhesion, permit traction forces important for cell migration, and cross-talk with growth factor receptors to regulate cell pro…

  Authors: Eloi Montanez, Aleksandra Piwko-Czuchra, Martina Bauer, Shaohua Li, Peter Yurchenco, Reinhard Fässler

  Source: Methods in enzymology. 2007

  View Full Text

• Myocardial ischaemia-reperfusion injury in haematopoietic cell-restricted beta1 integrin knockout mice.

  Evidence indicates that the intercellular adhesion molecule-1 and its counter-receptor beta2 integrin are cardioprotective proteins during myocardial …

  Authors: Bernhard Metzler, Bernhard Haubner, Elisabetta Conci, Jakob Voelkl, Johannes Jehle, Martina Bauer, Dominik Wolf, Otmar Pachinger, Qingbo Xu

  Source: Experimental physiology. 2008 Jul

  View Full Text

• Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity.

  Inhibiting the alpha(4) subunit of the integrin heterodimers alpha(4)beta(1) and alpha(4)beta(7) with the monoclonal antibody natalizumab is an effect…

  Authors: Martina Bauer, Cord Brakebusch, Caroline Coisne, Michael Sixt, Hartmut Wekerle, Britta Engelhardt, Reinhard Fässler

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2009 Feb 10

  View Free Full Text

• Beta1 integrin-mediated adhesion signalling is essential for epidermal progenitor cell expansion.

  BACKGROUND: There is a major discrepancy between the in vitro and in vivo results regarding the role of beta1 integrins in the maintenance of epiderma…

  Authors: Aleksandra Piwko-Czuchra, Heidi Koegel, Hannelore Meyer, Martina Bauer, Sabine Werner, Cord Brakebusch, Reinhard Fässler

  Source: PloS one. 2009

  View Full Text