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p97 adaptor choice regulates organelle biogenesis.
The AAA protein p97 requires adaptor-like cofactors for its numerous cellular functions. In this issue of Developmental Cell, Uchiyama et al. (2006) i…
Authors: Martin Latterich
Source: Developmental cell. 2006 Dec
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p97: The cell's molecular purgatory?
The multifunctional AAA-ATPase p97/VCP is one of the most extensively studied members of this protein family, yet it presents the field with many perp…
Authors: Dalia Halawani, Martin Latterich
Source: Molecular cell. 2006 Jun 23
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Hereditary inclusion body myopathy-linked p97/VCP mutations in the NH2 domain and the D1 ring modulate p97/VCP ATPase activity and D2 ring conformation.
Hereditary inclusion body myopathy associated with early-onset Paget disease of bone and frontotemporal dementia (hIBMPFTD) is a degenerative disorder…
Authors: Dalia Halawani, Andréa C LeBlanc, Isabelle Rouiller, Stephen W Michnick, Marc J Servant, Martin Latterich
Source: Molecular and cellular biology. 2009 Aug
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GTPase-mediated regulation of the unfolded protein response in Caenorhabditis elegans is dependent on the AAA+ ATPase CDC-48.
When endoplasmic reticulum (ER) homeostasis is perturbed, an adaptive mechanism is triggered and named the unfolded protein response (UPR). Thus far, …
Authors: Marie-Elaine Caruso, Sarah Jenna, Marion Bouchecareilh, David L Baillie, Daniel Boismenu, Dalia Halawani, Martin Latterich, Eric Chevet
Source: Molecular and cellular biology. 2008 Jul
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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane.
Bcl-2 family proteins regulate the release of proteins like cytochrome c from mitochondria during apoptosis. We used cell-free systems and ultimately …
Authors: Tomomi Kuwana, Mason R Mackey, Guy Perkins, Mark H Ellisman, Martin Latterich, Roger Schneiter, Douglas R Green, Donald D Newmeyer
Source: Cell. 2002 Nov 1
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TOE1 interacts with p53 to modulate its transactivation potential.
The TOE1 gene was discovered as a target of the Egr1 transcription factor that participates in cell growth regulation through the upregulation of p21 …
Authors: Sabina Sperandio, Saverio Tardito, Aleksandra Surzycki, Martin Latterich, Ian de Belle
Source: FEBS letters. 2009 Jul 7
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Two methods of whole-genome amplification enable accurate genotyping across a 2320-SNP linkage panel.
Comprehensive genome scans involving many thousands of SNP assays will require significant amounts of genomic DNA from each sample. We report two succ…
Authors: David L Barker, Mark S T Hansen, A Fawad Faruqi, Diane Giannola, Orlando R Irsula, Roger S Lasken, Martin Latterich, Vladimir Makarov, Arnold Oliphant, Jonathon H Pinter,…
Source: Genome research. 2004 May
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DNA damage modulates nucleolar interaction of the Werner protein with the AAA ATPase p97/VCP.
We report a novel nucleolar interaction between the AAA ATPase p97/VCP and the Werner protein (WRNp), a member of the RecQ helicase family. p97/VCP me…
Authors: Juneth Joaquin Partridge, Joseph Onofrio Lopreiato, Martin Latterich, Fred Eliezer Indig
Source: Molecular biology of the cell. 2003 Oct
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Proteomics of nasal mucus in chronic rhinosinusitis.
BACKGROUND: Chronic rhinosinusitis (CRS) is among the three most common chronic diseases in North America. The area of proteomics research is providin…
Authors: Marc A Tewfik, Martin Latterich, Marcos R DiFalco, Mark Samaha
Source: American journal of rhinology. 2007 Nov-Dec
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Label-free detection of biomolecular interactions in real time with a nano-porous silicon-based detection method.
BACKGROUND: We describe a biosensor platform for monitoring molecular interactions that is based on the combination of a defined nano-porous silicon s…
Authors: Martin Latterich, Jacques Corbeil
Source: Proteome science. 2008
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