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1 to 10 of 23 literature results
Class B G protein-coupled receptors (GPCRs) regulate a wide range of endocrine and neuroendocrine functions and are endogenously stimulated by moderat…
Authors: Martin Beinborn
Source: Molecular pharmacology. 2006 Jul
View Full TextThe relative simplicity and high specificity of peptide therapeutics has fueled recent interest. However, peptide and protein drugs generally require …
Authors: He Meng, Subrahmanian Tarakkad Krishnaji, Martin Beinborn, Krishna Kumar
Source: Journal of medicinal chemistry. 2008 Nov 27
View Free Full TextThe control of glucose metabolism is a complex process, and dysregulation at any level can cause impaired glucose tolerance and insulin resistance. Th…
Authors: Olga V Danilova, Albert K Tai, Deanna A Mele, Martin Beinborn, Andrew B Leiter, Andrew S Greenberg, James W Perfield, Jason Defuria, Praful S Singru, Ronald M Lechan,…
Source: Endocrinology. 2009 Dec
View Full TextThe GABA receptor (GABABR) is a class C G protein-coupled receptor (GPCR) that functions as an obligate heterodimer, composed of two heptahelical subu…
Authors: Richa S Mukherjee, Edward W McBride, Martin Beinborn, Kathleen Dunlap, Alan S Kopin
Source: Molecular pharmacology. 2006 Oct
View Full TextTo elucidate the receptor-bound conformation of glucagon-like peptide-1 (GLP-1), a series of conformationally constrained GLP-1 analogues were synthes…
Authors: Eunice N Murage, Jonathan C Schroeder, Martin Beinborn, Jung-Mo Ahn
Source: Bioorganic & medicinal chemistry. 2008 Dec 1
View Full TextIt has been proposed that mutations that induce constitutive activity in G-protein-coupled receptors (GPCRs) concomitantly enhance the ability of part…
Authors: Martin Beinborn, Yong Ren, Michael Bläker, Ci Chen, Alan S Kopin
Source: Molecular pharmacology. 2004 Mar
View Full TextGlucagon-like peptide-1 (GLP-1) and its cognate receptor play an important physiological role in maintaining blood glucose homeostasis. A GLP-1 recept…
Authors: Martin Beinborn, Christine I Worrall, Edward W McBride, Alan S Kopin
Source: Regulatory peptides. 2005 Aug 15
View Full TextThis report focuses on a 59-year-old male Japanese patient with Ménétrier's disease who suffered from severe hypoproteinemia and tested positive for H…
Authors: Kazuhiro Watanabe, Martin Beinborn, Shinya Nagamatsu, Hitoshi Ishida, Shin'ichi Takahashi
Source: Scandinavian journal of gastroenterology. 2005 Apr
View Full TextPeptide hormones radiolabeled with 125I are widely used for the pharmacological characterization of cognate receptors. As a prerequisite for calculati…
Authors: Amanda C Doran, Yieh-Ping Wan, Alan S Kopin, Martin Beinborn
Source: Biochemical pharmacology. 2003 May 1
View Full TextBACKGROUND: The anaphylatoxins, C3a and C5a, that are generated during trauma, major surgery, or infection are potent proinflammatory mediators that i…
Authors: Tsukasa Takabayashi, Soichi Shimizu, Burton D Clark, Martin Beinborn, John F Burke, Jeffrey A Gelfand
Source: Surgery. 2004 May
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