1 to 10 of 23 literature results

• Class B GPCRs: a hidden agonist within?

  Class B G protein-coupled receptors (GPCRs) regulate a wide range of endocrine and neuroendocrine functions and are endogenously stimulated by moderat…

  Authors: Martin Beinborn

  Source: Molecular pharmacology. 2006 Jul

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• Influence of selective fluorination on the biological activity and proteolytic stability of glucagon-like peptide-1.

  The relative simplicity and high specificity of peptide therapeutics has fueled recent interest. However, peptide and protein drugs generally require …

  Authors: He Meng, Subrahmanian Tarakkad Krishnaji, Martin Beinborn, Krishna Kumar

  Source: Journal of medicinal chemistry. 2008 Nov 27

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• Neurogenin 3-specific dipeptidyl peptidase-2 deficiency causes impaired glucose tolerance, insulin resistance, and visceral obesity.

  The control of glucose metabolism is a complex process, and dysregulation at any level can cause impaired glucose tolerance and insulin resistance. Th…

  Authors: Olga V Danilova, Albert K Tai, Deanna A Mele, Martin Beinborn, Andrew B Leiter, Andrew S Greenberg, James W Perfield, Jason Defuria, Praful S Singru, Ronald M Lechan,…

  Source: Endocrinology. 2009 Dec

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• Point mutations in either subunit of the GABAB receptor confer constitutive activity to the heterodimer.

  The GABA receptor (GABABR) is a class C G protein-coupled receptor (GPCR) that functions as an obligate heterodimer, composed of two heptahelical subu…

  Authors: Richa S Mukherjee, Edward W McBride, Martin Beinborn, Kathleen Dunlap, Alan S Kopin

  Source: Molecular pharmacology. 2006 Oct

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• Search for alpha-helical propensity in the receptor-bound conformation of glucagon-like peptide-1.

  To elucidate the receptor-bound conformation of glucagon-like peptide-1 (GLP-1), a series of conformationally constrained GLP-1 analogues were synthes…

  Authors: Eunice N Murage, Jonathan C Schroeder, Martin Beinborn, Jung-Mo Ahn

  Source: Bioorganic & medicinal chemistry. 2008 Dec 1

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• Ligand function at constitutively active receptor mutants is affected by two distinct yet interacting mechanisms.

  It has been proposed that mutations that induce constitutive activity in G-protein-coupled receptors (GPCRs) concomitantly enhance the ability of part…

  Authors: Martin Beinborn, Yong Ren, Michael Bläker, Ci Chen, Alan S Kopin

  Source: Molecular pharmacology. 2004 Mar

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• A human glucagon-like peptide-1 receptor polymorphism results in reduced agonist responsiveness.

  Glucagon-like peptide-1 (GLP-1) and its cognate receptor play an important physiological role in maintaining blood glucose homeostasis. A GLP-1 recept…

  Authors: Martin Beinborn, Christine I Worrall, Edward W McBride, Alan S Kopin

  Source: Regulatory peptides. 2005 Aug 15

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• Ménétrier's disease in a patient with Helicobacter pylori infection is linked to elevated glucagon-like peptide-2 activity.

  This report focuses on a 59-year-old male Japanese patient with Ménétrier's disease who suffered from severe hypoproteinemia and tested positive for H…

  Authors: Kazuhiro Watanabe, Martin Beinborn, Shinya Nagamatsu, Hitoshi Ishida, Shin'ichi Takahashi

  Source: Scandinavian journal of gastroenterology. 2005 Apr

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• Established theory of radiation-induced decay is not generalizable to Bolton-Hunter labeled peptides.

  Peptide hormones radiolabeled with 125I are widely used for the pharmacological characterization of cognate receptors. As a prerequisite for calculati…

  Authors: Amanda C Doran, Yieh-Ping Wan, Alan S Kopin, Martin Beinborn

  Source: Biochemical pharmacology. 2003 May 1

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• Interleukin-1 upregulates anaphylatoxin receptors on mononuclear cells.

  BACKGROUND: The anaphylatoxins, C3a and C5a, that are generated during trauma, major surgery, or infection are potent proinflammatory mediators that i…

  Authors: Tsukasa Takabayashi, Soichi Shimizu, Burton D Clark, Martin Beinborn, John F Burke, Jeffrey A Gelfand

  Source: Surgery. 2004 May

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