1 to 10 of 11 literature results

• Enzyme-catalyzed activation of anticancer prodrugs.

  The rationale fo the development of prodrugs relies upon delivery of higher concentrations of a drug to target cells compared to administration of the…

  Authors: Martijn Rooseboom, Jan N M Commandeur, Nico P E Vermeulen

  Source: Pharmacological reviews. 2004 Mar

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• Human CXCR2 (hCXCR2) takes over functionalities of its murine homolog in hCXCR2 knockin mice.

  Human CXCR2 (hCXCR2) has been implicated in diverse inflammatory diseases. When roles of this receptor studied in animal models are extrapolated into …

  Authors: Katsuhiro Mihara, Martin-Jan Smit, Magda Krajnc-Franken, Jan Gossen, Martijn Rooseboom, Wim Dokter

  Source: European journal of immunology. 2005 Sep

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• Functional replacement of murine CXCR2 by its human homologue in the development of atherosclerosis in LDLR knockout mice.

  The CXC chemokine receptor CXCR2 has been implicated in the pathogenesis of several chronic diseases including atherosclerosis. To enable animal studi…

  Authors: Katsuhiro Mihara, Mirjam Spansier, Martijn Rooseboom, Martin-Jan Smit, Wim Dokter

  Source: Biological & pharmaceutical bulletin. 2007 Jul

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• Comparative study on the bioactivation mechanisms and cytotoxicity of Te-phenyl-L-tellurocysteine, Se-phenyl-L-selenocysteine, and S-phenyl-L-cysteine.

  Tellurium compounds are effective antioxidants and chemoprotectors, even more active than their selenium and sulfur analogues. In addition to these pr…

  Authors: Martijn Rooseboom, Nico P E Vermeulen, Fatma Durgut, Jan N M Commandeur

  Source: Chemical research in toxicology. 2002 Dec

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• Modeling and molecular dynamics of glutamine transaminase K/cysteine conjugate beta-lyase.

  The homodimeric, pyridoxal 5'-phosphate (PLP)-dependent enzyme glutamine transaminase K/cysteine conjugate beta-lyase (GTK/beta-lyase) has been implic…

  Authors: Jennifer Venhorst, Antonius M ter Laak, Moira Meijer, Ineke van de Wetering, Jan N M Commandeur, Martijn Rooseboom, Nico P E Vermeulen

  Source: Journal of molecular graphics & modelling. 2003 Sep

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• Imidazolylpyrimidine based CXCR2 chemokine receptor antagonists.

  An imidazolylpyrimidine was identified in a CXCR2 chemokine receptor antagonist screen and was optimized for potency, in vitro metabolic stability, an…

  Authors: Koc-Kan Ho, Douglas S Auld, Adolph C Bohnstedt, Paolo Conti, Wim Dokter, Shawn Erickson, Daming Feng, Jim Inglese, Celia Kingsbury, Steven G Kultgen,…

  Source: Bioorganic & medicinal chemistry letters. 2006 May 15

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• Induction of glutathione-S-transferase mRNA levels by chemopreventive selenocysteine Se-conjugates.

  Several selenocysteine Se-conjugates (SeCys-conjugates) prevent against chemically induced carcinogenesis. Bioactivation to selenols (RSeH) by beta-ly…

  Authors: Peter A C 't Hoen, Martijn Rooseboom, Martin K Bijsterbosch, Theo J C van Berkel, Nico P E Vermeulen, Jan N M Commandeur

  Source: Biochemical pharmacology. 2002 May 15

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• Tissue distribution of cytosolic beta-elimination reactions of selenocysteine Se-conjugates in rat and human.

  Selenocysteine Se-conjugates (e.g. methylselenocysteine) have been shown to be potent chemopreventive and chemoprotective agents, and inducers of apop…

  Authors: Martijn Rooseboom, Nico P E Vermeulen, Ed J Groot, Jan N M Commandeur

  Source: Chemico-biological interactions. 2002 Aug 15

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• Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories.

  Caco-2 cells, widely used to study carrier mediated uptake and efflux mechanisms, are known to have different properties when cultured under different…

  Authors: Rose Hayeshi, Constanze Hilgendorf, Per Artursson, Patrick Augustijns, Birger Brodin, Pascale Dehertogh, Karen Fisher, Lina Fossati, Egbert Hovenkamp, Timo Korjamo,…

  Source: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2008 Dec 18

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• Enzymatic pathways of beta elimination of chemopreventive selenocysteine Se conjugates.

  Authors: Martijn Rooseboom, Nico P E Vermeulen, Jan N M Commandeur

  Source: Methods in enzymology. 2002

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