1 to 10 of 22 literature results

• Protein and lipid binding parameters in rainbow trout (Oncorhynchus mykiss) blood and liver fractions to extrapolate from an in vitro metabolic degradation assay to in vivo bioaccumulation potential of hydrophobic organic chemicals.

  Binding of hydrophobic chemicals to colloids such as proteins or lipids is difficult to measure using classical microdialysis methods due to low aqueo…

  Authors: Beate I Escher, Christina E Cowan-Ellsberry, Scott Dyer, Michelle R Embry, Susan Erhardt, Marlies Halder, Jung-Hwan Kwon, Karla Johanning, Mattheus T T Oosterwijk, Sibylle Rutishauser,…

  Source: Chemical research in toxicology. 2011 Jul 18

  View Full Text

• International validation of pyrogen tests based on cryopreserved human primary blood cells.

  Pyrogens as fever-inducing agents can be a major health hazard in parenterally applied drugs. For the control of these contaminants, pyrogen testing f…

  Authors: Stefanie Schindler, Ingo Spreitzer, Bettina Löschner, Sebastian Hoffmann, Kilian Hennes, Marlies Halder, Peter Brügger, Esther Frey, Thomas Hartung, Thomas Montag

  Source: Journal of immunological methods. 2006 Oct 20

  View Full Text

• The consistency approach for quality control of vaccines - a strategy to improve quality control and implement 3Rs.

  Current batch release testing of established vaccines emphasizes quality control of the final product and is often characterized by extensive use of a…

  Authors: Fabrizio De Mattia, Jean-Michel Chapsal, Johan Descamps, Marlies Halder, Nicholas Jarrett, Imke Kross, Frederic Mortiaux, Cecile Ponsar, Keith Redhead, Jo McKelvie,…

  Source: Biologicals : journal of the International Association of Biological Standardization. 2011 Jan

  View Full Text

• Three Rs Approaches in the Production and Quality Control of Fish Vaccines.

  The workshop on Three Rs Approaches in the Production and Quality Control of Fish Vaccines aimed a) to identify animal tests currently stipulated for …

  Authors: Paul J Midtlyng, Coenraad Hendriksen, Elisabeth Balks, Lukas Bruckner, Lawrence Elsken, Oystein Evensen, Kjetil Fyrand, Allison Guy, Marlies Halder, Penny Hawkins,…

  Source: Biologicals : journal of the International Association of Biological Standardization. 2011 Mar

  View Full Text

• Implementation and enforcement of the 3Rs principle in the field of transgenic animals used for scientific purposes. Report and recommendations of the BfR expert workshop, May 18-20, 2009, Berlin, Germany.

  In 2007, 2.7 million vertebrates were used for animal experiments and other scientific purposes in Germany alone. Since 1998 there has been an increas…

  Authors: Ariane Kretlow, Daniel Butzke, Mario E Goetz, Barbara Grune, Marlies Halder, Frank Henkler, Manfred Liebsch, Rainer Nobiling, Michael Oelgeschlaeger, Kurt Reifenberg,…

  Source: ALTEX. 2010

  View Full Text

• The fish embryo toxicity test as an animal alternative method in hazard and risk assessment and scientific research.

  Animal alternatives research has historically focused on human safety assessments and has only recently been extended to environmental testing. This i…

  Authors: Michelle R Embry, Scott E Belanger, Thomas A Braunbeck, Malyka Galay-Burgos, Marlies Halder, David E Hinton, Marc A Léonard, Adam Lillicrap, Teresa Norberg-King, Graham Whale

  Source: Aquatic toxicology (Amsterdam, Netherlands). 2010 Apr 15

  View Full Text

• Regulatory aspects on the use of fish embryos in environmental toxicology.

  Animal alternative tests are gaining serious consideration in an array of environmental sciences, particularly as they relate to sound management of c…

  Authors: Marlies Halder, Marc Léonard, Taisen Iguchi, James T Oris, Kathy Ryder, Scott E Belanger, Thomas A Braunbeck, Michelle R Embry, Graham Whale, Teresa Norberg-King,…

  Source: Integrated environmental assessment and management. 2010 Jul

  View Full Text

• The consistency approach for the quality control of vaccines.

  Current lot release testing of conventional vaccines emphasizes quality control of the final product and is characterized by its extensive use of labo…

  Authors: Coenraad Hendriksen, Juan L Arciniega, Lukas Bruckner, Michel Chevalier, Emmanuelle Coppens, Johan Descamps, Michel Duchêne, David Michael Dusek, Marlies Halder, Hans Kreeftenberg,…

  Source: Biologicals : journal of the International Association of Biological Standardization. 2008 Jan

  View Full Text

• ECVAM'S activities in the EU candidate countries.

  ECVAM has been given a special grant for collaborative projects on alternative/advanced testing methods involving eleven Candidate Countries for membe…

  Authors: Dariusz Sladowski, Marlies Halder

  Source: Alternatives to laboratory animals : ATLA. 2002 Dec

  View Full Text

• ECVAM's role in the implementation of the Three Rs concept in the field of biologicals.

  Biologicals can be defined as products that are derived from living organisms or are produced by them. They include vaccines, hormones, monoclonal and…

  Authors: Coenraad Hendriksen, Klaus Cussler, Marlies Halder

  Source: Alternatives to laboratory animals : ATLA. 2002 Dec

  View Full Text