1 to 10 of 20 literature results

• Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells.

  Integrin activation is essential for the function of all blood cells, including platelets and leukocytes. The blood cell-specific FERM domain protein …

  Authors: Markus Moser, Martina Bauer, Stephan Schmid, Raphael Ruppert, Sarah Schmidt, Michael Sixt, Hao-Ven Wang, Markus Sperandio, Reinhard Fässler

  Source: Nature medicine. 2009 Mar

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• Glycosylation in immune cell trafficking.

  Leukocyte recruitment encompasses cell adhesion and activation steps that enable circulating leukocytes to roll, arrest, and firmly adhere on the endo…

  Authors: Markus Sperandio, Christian A Gleissner, Klaus Ley

  Source: Immunological reviews. 2009 Jul

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• A fundamental role of mAbp1 in neutrophils: impact on beta(2) integrin-mediated phagocytosis and adhesion in vivo.

  The mammalian actin-binding protein 1 (mAbp1, Hip-55, SH3P7) is phosphorylated by the nonreceptor tyrosine kinase Syk that has a fundamental effect fo…

  Authors: Jürgen Schymeinsky, Ronald Gerstl, Ingrid Mannigel, Katy Niedung, David Frommhold, Klaus Panthel, Jürgen Heesemann, Michael Sixt, Thomas Quast, Waldemar Kolanus,…

  Source: Blood. 2009 Nov 5

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• Intracapillary leukocyte accumulation as a novel antihemorrhagic mechanism in acute pancreatitis in mice.

  Background & AIMS: Pancreatic infiltration by leukocytes represents a hallmark in acute pancreatitis. Although leukocytes play an active role in the p…

  Authors: Eduard Ryschich, Vachtang Kerkadze, Olegas Deduchovas, Olga Salnikova, Audris Parseliunas, Angela Märten, Werner Hartwig, Markus Sperandio, Jan Schmidt

  Source: Gut. 2009 May 20

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• Leukocyte trafficking in a mouse model for leukocyte adhesion deficiency II/congenital disorder of glycosylation IIc.

  Leukocyte adhesion deficiency II (LAD II), also known as congenital disorder of glycosylation IIc (CDG-IIc), is a human disease in which a defective G…

  Authors: Sviatlana Yakubenia, David Frommhold, Dirk Schölch, Christina C Hellbusch, Christian Körner, Björn Petri, Claire Jones, Ute Ipe, M Gabriele Bixel, Robert Krempien,…

  Source: Blood. 2008 Aug 15

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• Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis.

  The CXC ligand (CXCL)12/CXC receptor (CXCR)4 chemokine-receptor axis controls hematopoiesis, organ development, and angiogenesis, but its role in the …

  Authors: Alma Zernecke, Ilze Bot, Yassin Djalali-Talab, Erdenechimeg Shagdarsuren, Kiril Bidzhekov, Svenja Meiler, Regina Krohn, Andreas Schober, Markus Sperandio, Oliver Soehnlein,…

  Source: Circulation research. 2008 Feb 1

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• The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for beta2 integrin (CD11/CD18)-mediated neutrophil migration.

  Leukocyte adhesion via beta(2) integrins (CD11/CD18) activates the tyrosine kinase Syk. We found that Syk was enriched at the lamellipodium during N-f…

  Authors: Jurgen Schymeinsky, Anca Sindrilaru, David Frommhold, Markus Sperandio, Ronald Gerstl, Cornelia Then, Attila Mócsai, Karin Scharffetter-Kochanek, Barbara Walzog

  Source: Blood. 2006 Dec 1

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• Autoperfused mouse flow chamber reveals synergistic neutrophil accumulation through P-selectin and E-selectin.

  To study rolling of mouse neutrophils on P- and E-selectins in whole blood and without cell isolation, we constructed an autoperfused flow chamber mad…

  Authors: Michael L Smith, Markus Sperandio, Elena V Galkina, Klaus Ley

  Source: Journal of leukocyte biology. 2004 Nov

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• Effectiveness and side effects of an escalating, stepwise approach to indomethacin treatment for symptomatic patent ductus arteriosus in premature infants below 33 weeks of gestation.

  OBJECTIVE: Symptomatic patent ductus arteriosus (sPDA) is a common problem in premature infants and can be treated effectively with intravenous indome…

  Authors: Markus Sperandio, Bernd Beedgen, Reinhard Feneberg, Christina Huppertz, Jürgen Brüssau, Johannes Pöschl, Otwin Linderkamp

  Source: Pediatrics. 2005 Dec

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• Alpha 2,3-sialyltransferase-IV is essential for L-selectin ligand function in inflammation.

  L-selectin belongs to the C-type lectin family of glycoproteins and is constitutively expressed on most leukocytes. L-selectin mediates leukocyte roll…

  Authors: Markus Sperandio, David Frommhold, Inna Babushkina, Lesley G Ellies, Timothy S Olson, Michael L Smith, Benedikt Fritzsching, Eva Pauly, David F Smith, Rainer Nobiling,…

  Source: European journal of immunology. 2006 Dec

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