1 to 10 of 49 literature results

• Kindlin-3 is essential for integrin activation and platelet aggregation.

  Integrin-mediated platelet adhesion and aggregation are essential for sealing injured blood vessels and preventing blood loss, and excessive platelet …

  Authors: Markus Moser, Bernhard Nieswandt, Siegfried Ussar, Miroslava Pozgajova, Reinhard Fässler

  Source: Nature medicine. 2008 Mar

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• Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation.

  Integrins are the major adhesion receptors of leukocytes and platelets. Beta1 and beta2 integrin function on leukocytes is crucial for a successful im…

  Authors: Lena Svensson, Kimberley Howarth, Alison McDowall, Irene Patzak, Rachel Evans, Siegfried Ussar, Markus Moser, Ayse Metin, Mike Fried, Ian Tomlinson,…

  Source: Nature medicine. 2009 Mar

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• Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells.

  Integrin activation is essential for the function of all blood cells, including platelets and leukocytes. The blood cell-specific FERM domain protein …

  Authors: Markus Moser, Martina Bauer, Stephan Schmid, Raphael Ruppert, Sarah Schmidt, Michael Sixt, Hao-Ven Wang, Markus Sperandio, Reinhard Fässler

  Source: Nature medicine. 2009 Mar

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• SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function.

  Stable isotope labeling by amino acids in cell culture (SILAC) has become a versatile tool for quantitative, mass spectrometry (MS)-based proteomics. …

  Authors: Marcus Krüger, Markus Moser, Siegfried Ussar, Ingo Thievessen, Christian A Luber, Francesca Forner, Sarah Schmidt, Sara Zanivan, Reinhard Fässler, Matthias Mann

  Source: Cell. 2008 Jul 25

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• Kindlin-2 controls bidirectional signaling of integrins.

  Control of integrin activation is required for cell adhesion and ligand-induced signaling. Here we report that loss of the focal adhesion protein Kind…

  Authors: Eloi Montanez, Siegfried Ussar, Martina Schifferer, Michael Bösl, Roy Zent, Markus Moser, Reinhard Fässler

  Source: Genes & development. 2008 May 15

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• Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions.

  Leukocyte adhesion deficiency (LAD)-III is associated with homozygous stop codon mutations in Kindlin-3, the hematopoietic member of the Kindlin famil…

  Authors: Eugenia Manevich-Mendelson, Sara W Feigelson, Ronit Pasvolsky, Memet Aker, Valentin Grabovsky, Ziv Shulman, Sara Sebnem Kilic, Maria Alessandra Rosenthal-Allieri, Shifra Ben-Dor, Adi Mory,…

  Source: Blood. 2009 Sep 10

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• LAD-1/variant syndrome is caused by mutations in FERMT3.

  Leukocyte adhesion deficiency-1/variant (LAD1v) syndrome presents early in life and manifests by infections without pus formation in the presence of a…

  Authors: Taco W Kuijpers, Edith van de Vijver, Marian A J Weterman, Martin de Boer, Anton T J Tool, Timo K van den Berg, Markus Moser, Marja E Jakobs, Karl Seeger, Ozden Sanal,…

  Source: Blood. 2009 May 7

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• Mutations in SIL1 cause Marinesco-Sjögren syndrome, a cerebellar ataxia with cataract and myopathy.

  SIL1 (also called BAP) acts as a nucleotide exchange factor for the Hsp70 chaperone BiP (also called GRP78), which is a key regulator of the main func…

  Authors: Jan Senderek, Michael Krieger, Claudia Stendel, Carsten Bergmann, Markus Moser, Nico Breitbach-Faller, Sabine Rudnik-Schöneborn, Astrid Blaschek, Nicole I Wolf, Inga Harting,…

  Source: Nature genetics. 2005 Dec

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• Bone morphogenic proteins are overexpressed in malignant melanoma and promote cell invasion and migration.

  Malignant melanoma cells are known to have altered expression of growth factors compared with normal human melanocytes. These changes probably favor t…

  Authors: Tanja Rothhammer, Ina Poser, Fabrice Soncin, Frauke Bataille, Markus Moser, Anja-Katrin Bosserhoff

  Source: Cancer research. 2005 Jan 15

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• Targeted disruption of Slc2a8 (GLUT8) reduces motility and mitochondrial potential of spermatozoa.

  GLUT8 is a class 3 sugar transport facilitator which is predominantly expressed in testis and also detected in brain, heart, skeletal muscle, adipose …

  Authors: Verena Gawlik, Stefan Schmidt, Andrea Scheepers, Gunther Wennemuth, Robert Augustin, Gerhard Aumüller, Markus Moser, Hadi Al-Hasani, Reinhart Kluge, Hans-Georg Joost,…

  Source: Molecular membrane biology. 2008 Apr

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