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BACKGROUND: Amputations in people with type 2 diabetes mellitus substantially impair their quality of life and impose high costs on health-care system…
Authors: Kushwin Rajamani, Peter G Colman, Li Ping Li, James D Best, Merryn Voysey, Michael C D'Emden, Markku Laakso, John R Baker, Anthony C Keech, FIELD study investigators
Source: Lancet. 2009 May 23
View Full TextGenome-wide association studies have shown that variation in MTNR1B (melatonin receptor 1B) is associated with insulin and glucose concentrations. Her…
Authors: Valeriya Lyssenko, Cecilia L F Nagorny, Michael R Erdos, Nils Wierup, Anna Jonsson, Peter Spégel, Marco Bugliani, Richa Saxena, Malin Fex, Nicolo Pulizzi,…
Source: Nature genetics. 2009 Jan
View Full TextType 2 (non-insulin-dependent) diabetes mellitus is a progressive metabolic disorder arising from genetic and environmental factors that impair beta c…
Authors: Alexander V Chibalin, Ying Leng, Elaine Vieira, Anna Krook, Marie Björnholm, Yun Chau Long, Olga Kotova, Zhihui Zhong, Fumio Sakane, Tatiana Steiler,…
Source: Cell. 2008 Feb 8
View Full TextDiminished mitochondrial oxidative phosphorylation and aerobic capacity are associated with reduced longevity. We tested whether resveratrol (RSV), wh…
Authors: Marie Lagouge, Carmen Argmann, Zachary Gerhart-Hines, Hamid Meziane, Carles Lerin, Frederic Daussin, Nadia Messadeq, Jill Milne, Philip Lambert, Peter Elliott,…
Source: Cell. 2006 Dec 15
View Full TextBlood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels are risk factors for cardiovascula…
Authors: Sekar Kathiresan, Cristen J Willer, Gina M Peloso, Serkalem Demissie, Kiran Musunuru, Eric E Schadt, Lee Kaplan, Derrick Bennett, Yun Li, Toshiko Tanaka,…
Source: Nature genetics. 2009 Jan
View Free Full TextOBJECTIVE: We evaluated insulin sensitivity and insulin secretion across the entire range of fasting (FPG) and 2-h plasma glucose (PG), and we investi…
Authors: Alena Stancáková, Martin Javorský, Teemu Kuulasmaa, Steven M Haffner, Johanna Kuusisto, Markku Laakso
Source: Diabetes. 2009 May
View Full TextPeroxisome proliferator-activated receptor (PPAR) alpha, a transcription factor of the nuclear receptor superfamily, regulates fatty acid oxidation. W…
Authors: Laura Andrulionyte, Teemu Kuulasmaa, Jean-Louis Chiasson, Markku Laakso, STOP-NIDDM Study Group
Source: Diabetes. 2007 Apr
View Full TextFamilial combined hyperlipidemia (FCHL), characterized by elevated levels of serum total cholesterol, triglycerides or both, is observed in about 20% …
Authors: Päivi Pajukanta, Heidi E Lilja, Janet S Sinsheimer, Rita M Cantor, Aldons J Lusis, Massimiliano Gentile, Xiaoqun Joyce Duan, Aino Soro-Paavonen, Jussi Naukkarinen, Janna Saarela,…
Source: Nature genetics. 2004 Apr
View Full TextPURPOSE OF REVIEW: Both insulin resistance and dyslipidaemia are determined by genetic and environmental factors. Depending on their expression and th…
Authors: Markku Laakso
Source: Current opinion in lipidology. 2004 Apr
View Full TextOBJECTIVE: We investigated the effects of 18 confirmed type 2 diabetes risk single nucleotide polymorphisms (SNPs) on insulin sensitivity, insulin sec…
Authors: Alena Stancáková, Teemu Kuulasmaa, Jussi Paananen, Anne U Jackson, Lori L Bonnycastle, Francis S Collins, Michael Boehnke, Johanna Kuusisto, Markku Laakso
Source: Diabetes. 2009 Sep
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