1 to 10 of 189 literature results

• Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): a prespecified analysis of a randomised controlled trial.

  BACKGROUND: Amputations in people with type 2 diabetes mellitus substantially impair their quality of life and impose high costs on health-care system…

  Authors: Kushwin Rajamani, Peter G Colman, Li Ping Li, James D Best, Merryn Voysey, Michael C D'Emden, Markku Laakso, John R Baker, Anthony C Keech, FIELD study investigators

  Source: Lancet. 2009 May 23

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• Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.

  Genome-wide association studies have shown that variation in MTNR1B (melatonin receptor 1B) is associated with insulin and glucose concentrations. Her…

  Authors: Valeriya Lyssenko, Cecilia L F Nagorny, Michael R Erdos, Nils Wierup, Anna Jonsson, Peter Spégel, Marco Bugliani, Richa Saxena, Malin Fex, Nicolo Pulizzi,…

  Source: Nature genetics. 2009 Jan

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• Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.

  Type 2 (non-insulin-dependent) diabetes mellitus is a progressive metabolic disorder arising from genetic and environmental factors that impair beta c…

  Authors: Alexander V Chibalin, Ying Leng, Elaine Vieira, Anna Krook, Marie Björnholm, Yun Chau Long, Olga Kotova, Zhihui Zhong, Fumio Sakane, Tatiana Steiler,…

  Source: Cell. 2008 Feb 8

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• Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.

  Diminished mitochondrial oxidative phosphorylation and aerobic capacity are associated with reduced longevity. We tested whether resveratrol (RSV), wh…

  Authors: Marie Lagouge, Carmen Argmann, Zachary Gerhart-Hines, Hamid Meziane, Carles Lerin, Frederic Daussin, Nadia Messadeq, Jill Milne, Philip Lambert, Peter Elliott,…

  Source: Cell. 2006 Dec 15

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• Common variants at 30 loci contribute to polygenic dyslipidemia.

  Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels are risk factors for cardiovascula…

  Authors: Sekar Kathiresan, Cristen J Willer, Gina M Peloso, Serkalem Demissie, Kiran Musunuru, Eric E Schadt, Lee Kaplan, Derrick Bennett, Yun Li, Toshiko Tanaka,…

  Source: Nature genetics. 2009 Jan

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• Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men.

  OBJECTIVE: We evaluated insulin sensitivity and insulin secretion across the entire range of fasting (FPG) and 2-h plasma glucose (PG), and we investi…

  Authors: Alena Stancáková, Martin Javorský, Teemu Kuulasmaa, Steven M Haffner, Johanna Kuusisto, Markku Laakso

  Source: Diabetes. 2009 May

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• Single nucleotide polymorphisms of the peroxisome proliferator-activated receptor-alpha gene (PPARA) influence the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.

  Peroxisome proliferator-activated receptor (PPAR) alpha, a transcription factor of the nuclear receptor superfamily, regulates fatty acid oxidation. W…

  Authors: Laura Andrulionyte, Teemu Kuulasmaa, Jean-Louis Chiasson, Markku Laakso, STOP-NIDDM Study Group

  Source: Diabetes. 2007 Apr

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• Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).

  Familial combined hyperlipidemia (FCHL), characterized by elevated levels of serum total cholesterol, triglycerides or both, is observed in about 20% …

  Authors: Päivi Pajukanta, Heidi E Lilja, Janet S Sinsheimer, Rita M Cantor, Aldons J Lusis, Massimiliano Gentile, Xiaoqun Joyce Duan, Aino Soro-Paavonen, Jussi Naukkarinen, Janna Saarela,…

  Source: Nature genetics. 2004 Apr

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• Gene variants, insulin resistance, and dyslipidaemia.

  PURPOSE OF REVIEW: Both insulin resistance and dyslipidaemia are determined by genetic and environmental factors. Depending on their expression and th…

  Authors: Markku Laakso

  Source: Current opinion in lipidology. 2004 Apr

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• Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.

  OBJECTIVE: We investigated the effects of 18 confirmed type 2 diabetes risk single nucleotide polymorphisms (SNPs) on insulin sensitivity, insulin sec…

  Authors: Alena Stancáková, Teemu Kuulasmaa, Jussi Paananen, Anne U Jackson, Lori L Bonnycastle, Francis S Collins, Michael Boehnke, Johanna Kuusisto, Markku Laakso

  Source: Diabetes. 2009 Sep

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