1 to 10 of 67 literature results

• Blimp-1 over Budapest.

  Blimp-1 is a transcription factor that affects the expression of hundreds of genes in lymphocytes. Recent work confirmed its role in the maturation of…

  Authors: Mark M Davis

  Source: Nature immunology. 2007 May

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• A prescription for human immunology.

  Inbred mice have been an extremely successful tool for basic immunology, but much less so as models of disease. Thus, to maximize the use of immunolog…

  Authors: Mark M Davis

  Source: Immunity. 2008 Dec 19

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• T cells as a self-referential, sensory organ.

  In light of recent data showing that both helper and cytotoxic T cells can detect even a single molecule of an agonist peptide-MHC, alphabeta T cells …

  Authors: Mark M Davis, Michelle Krogsgaard, Morgan Huse, Johannes Huppa, Bjoern F Lillemeier, Qi-jing Li

  Source: Annual review of immunology. 2007

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• The safety on the TCR trigger.

  In this issue, Xu et al. (2008) provide evidence for a new mechanism of T cell receptor regulation. Prior to activation, basic residues in the cytopla…

  Authors: Michael S Kuhns, Mark M Davis

  Source: Cell. 2008 Nov 14

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• Shouts, whispers and the kiss of death: directional secretion in T cells.

  T cells use secreted soluble factors for highly specific intercellular communication and targeted cell killing. This specificity is achieved first thr…

  Authors: Morgan Huse, Emily J Quann, Mark M Davis

  Source: Nature immunology. 2008 Oct

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• TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.

  The organization and dynamics of receptors and other molecules in the plasma membrane are not well understood. Here we analyzed the spatio-temporal dy…

  Authors: Björn F Lillemeier, Manuel A Mörtelmaier, Martin B Forstner, Johannes B Huppa, Jay T Groves, Mark M Davis

  Source: Nature immunology. 2010 Jan

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• TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.

  The recognition of foreign antigens by T lymphocytes is essential to most adaptive immune responses. It is driven by specific T-cell antigen receptors…

  Authors: Johannes B Huppa, Markus Axmann, Manuel A Mörtelmaier, Björn F Lillemeier, Evan W Newell, Mario Brameshuber, Lawrence O Klein, Gerhard J Schütz, Mark M Davis

  Source: Nature. 2010 Feb 18

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• An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a.

  Thymic positive selection is based on the interactions of T cell antigen receptors (TCRs) with self peptide-major histocompatibility complex (MHC) lig…

  Authors: Peter J R Ebert, Shan Jiang, Jianming Xie, Qi-Jing Li, Mark M Davis

  Source: Nature immunology. 2009 Nov

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• The alphabeta T cell repertoire comes into focus.

  The size of the lymphocyte repertoire is of great interest, but direct information has been elusive. Moon et al. (2007) report the enumeration and iso…

  Authors: Mark M Davis

  Source: Immunity. 2007 Aug

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• How T cells 'see' antigen.

  T lymphocytes bearing alphabeta T cell receptors are pivotal in the immune response of most vertebrates. For example, helper T cells orchestrate antib…

  Authors: Michelle Krogsgaard, Mark M Davis

  Source: Nature immunology. 2005 Mar

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