1 to 10 of 32 literature results

• The role of complement in the development of systemic lupus erythematosus.

  Complement has both beneficial and deleterious roles in the pathogenesis of systemic lupus erythematosus (SLE). On the one hand, patients with SLE pre…

  Authors: Anthony P Manderson, Marina Botto, Mark J Walport

  Source: Annual review of immunology. 2004

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• Regulation of B cell tolerance by 129-derived chromosome 1 loci in C57BL/6 mice.

  OBJECTIVE: Systemic lupus erythematosus is a multifactorial disease with a strong genetic component. Previous studies have shown that a 129-derived ch…

  Authors: Liliane Fossati-Jimack, Josefina Cortes-Hernandez, Peter J Norsworthy, H Terence Cook, Mark J Walport, Marina Botto

  Source: Arthritis and rheumatism. 2008 Jul

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• Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H.

  The alternative pathway of complement is activated continuously in vivo through the C3 'tick-over' pathway. This pathway is triggered by the hydrolysi…

  Authors: Matthew C Pickering, H Terence Cook, Joanna Warren, Anne E Bygrave, Jill Moss, Mark J Walport, Marina Botto

  Source: Nature genetics. 2002 Aug

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• C1q deficiency promotes the production of transgenic-derived IgM and IgG3 autoantibodies in anti-DNA knock-in transgenic mice.

  C1q-deficient mice have been shown to develop a lupus-like disease and to display an impaired clearance of apoptotic cells that are enriched in lupus …

  Authors: Liliane Fossati-Jimack, Josefina Cortes-Hernandez, Peter J Norsworthy, Mark J Walport, H Terence Cook, Marina Botto

  Source: Molecular immunology. 2008 Feb

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• Predominant role of IgM-dependent activation of the classical pathway in the clearance of dying cells by murine bone marrow-derived macrophages in vitro.

  Soluble molecules including complement components have been shown to facilitate the clearance of dying cells by phagocytes, a process that is importan…

  Authors: Pierre Quartier, Paul K Potter, Michael R Ehrenstein, Mark J Walport, Marina Botto

  Source: European journal of immunology. 2005 Jan

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• The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus.

  Systemic lupus erythematosus (SLE) is characterised by the production of autoantibodies against ubiquitous antigens, especially nuclear components. Ev…

  Authors: Anthony P Manderson, Francesco Carlucci, Peter J Lachmann, Robert A Lazarus, Richard J Festenstein, H Terence Cook, Mark J Walport, Marina Botto

  Source: Arthritis research & therapy. 2006

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• Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus.

  Relative deficiency of pentraxin proteins is implicated in the pathogenesis of systemic lupus erythematosus. The C-reactive protein (CRP) response is …

  Authors: Andrew I Russell, Deborah S Cunninghame Graham, Christopher Shepherd, Cheri A Roberton, John Whittaker, John Meeks, Richard J Powell, David A Isenberg, Mark J Walport, Timothy J Vyse

  Source: Human molecular genetics. 2004 Jan 1

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• Defective Fc-dependent processing of immune complexes in patients with systemic lupus erythematosus.

  OBJECTIVE: To explore the Fc receptor-dependent handling of immune complexes (ICs) by the fixed mononuclear phagocytic systems (MPS) in patients with …

  Authors: Kevin A Davies, Michael G Robson, A Michael Peters, Peter Norsworthy, Julian T Nash, Mark J Walport

  Source: Arthritis and rheumatism. 2002 Apr

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• Restoration of C1q levels by bone marrow transplantation attenuates autoimmune disease associated with C1q deficiency in mice.

  C1q deficiency in both humans and mice is strongly associated with autoimmunity. We have previously shown that bone marrow transplantation (BMT) resto…

  Authors: Josefina Cortes-Hernandez, Liliane Fossati-Jimack, Franz Petry, Michael Loos, Shozo Izui, Mark J Walport, H Terence Cook, Marina Botto

  Source: European journal of immunology. 2004 Dec

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• Monocytosis and accelerated activation of lymphocytes in C1q-deficient autoimmune-prone mice.

  C1q deficiency has been shown to accelerate spontaneous autoimmunity in mice. We studied the time course of activation of monocytes and lymphocytes in…

  Authors: Marten Trendelenburg, Anthony P Manderson, Liliane Fossati-Jimack, Mark J Walport, Marina Botto

  Source: Immunology. 2004 Sep

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