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Genome-wide association studies have identified hundreds of genetic variants associated with complex human diseases and traits, and have provided valu…
Authors: Teri A Manolio, Francis S Collins, Nancy J Cox, David B Goldstein, Lucia A Hindorff, David J Hunter, Mark I McCarthy, Erin M Ramos, Lon R Cardon, Aravinda Chakravarti,…
Source: Nature. 2009 Oct 8
View Full TextAuthors: Mark I McCarthy
Source: Nature genetics. 2008 Sep
View Full TextIdentification and characterization of genetic variants that either cause or predispose to diabetes are a major focus of biomedical research. As of ea…
Authors: Katharine R Owen, Mark I McCarthy
Source: Current opinion in genetics & development. 2007 Jun
View Full TextType 2 diabetes is a complex, multifactorial disease, for which genetic and environmental factors jointly determine susceptibility. Disentangling the …
Authors: Mark I McCarthy, Eleftheria Zeggini
Source: Trends in pharmacological sciences. 2007 Dec
View Full TextGenetic association studies are central to efforts to identify and characterise genomic variants underlying susceptibility to multifactorial disease. …
Authors: Andrew T Hattersley, Mark I McCarthy
Source: Lancet. 2005 Oct 8
View Full TextWe carried out a genome-wide association study of hemoglobin levels in 16,001 individuals of European and Indian Asian ancestry. The most closely asso…
Authors: John C Chambers, Weihua Zhang, Yun Li, Joban Sehmi, Mark N Wass, Delilah Zabaneh, Clive Hoggart, Henry Bayele, Mark I McCarthy, Leena Peltonen,…
Source: Nature genetics. 2009 Nov
View Full TextGenome-wide association studies have successfully identified numerous loci at which common variants influence disease risk or quantitative traits. Des…
Authors: Mark I McCarthy, Joel N Hirschhorn
Source: Human molecular genetics. 2008 Oct 15
View Free Full TextGenome-wide association studies (GWAS) of longitudinal birth cohorts enable joint investigation of environmental and genetic influences on complex tra…
Authors: Chiara Sabatti, Susan K Service, Anna-Liisa Hartikainen, Anneli Pouta, Samuli Ripatti, Jae Brodsky, Chris G Jones, Noah A Zaitlen, Teppo Varilo, Marika Kaakinen,…
Source: Nature genetics. 2009 Jan
View Free Full TextTo identify genetic factors influencing quantitative traits of biomedical importance, we conducted a genome-wide association study in 8,842 samples fr…
Authors: Yoon Shin Cho, Min Jin Go, Young Jin Kim, Jee Yeon Heo, Ji Hee Oh, Hyo-Jeong Ban, Dankyu Yoon, Mi Hee Lee, Dong-Joon Kim, Miey Park,…
Source: Nature genetics. 2009 May
View Full TextA substantial investment has been made in the generation of large public resources designed to enable the identification of tag SNP sets, but data est…
Authors: Eleftheria Zeggini, William Rayner, Andrew P Morris, Andrew T Hattersley, Mark Walker, Graham A Hitman, Panos Deloukas, Lon R Cardon, Mark I McCarthy
Source: Nature genetics. 2005 Dec
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