1 to 10 of 143 literature results

• Finding the missing heritability of complex diseases.

  Genome-wide association studies have identified hundreds of genetic variants associated with complex human diseases and traits, and have provided valu…

  Authors: Teri A Manolio, Francis S Collins, Nancy J Cox, David B Goldstein, Lucia A Hindorff, David J Hunter, Mark I McCarthy, Erin M Ramos, Lon R Cardon, Aravinda Chakravarti,…

  Source: Nature. 2009 Oct 8

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• Casting a wider net for diabetes susceptibility genes.

  Authors: Mark I McCarthy

  Source: Nature genetics. 2008 Sep

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• Genetics of type 2 diabetes.

  Identification and characterization of genetic variants that either cause or predispose to diabetes are a major focus of biomedical research. As of ea…

  Authors: Katharine R Owen, Mark I McCarthy

  Source: Current opinion in genetics & development. 2007 Jun

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• Genome-wide association scans for Type 2 diabetes: new insights into biology and therapy.

  Type 2 diabetes is a complex, multifactorial disease, for which genetic and environmental factors jointly determine susceptibility. Disentangling the …

  Authors: Mark I McCarthy, Eleftheria Zeggini

  Source: Trends in pharmacological sciences. 2007 Dec

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• What makes a good genetic association study?

  Genetic association studies are central to efforts to identify and characterise genomic variants underlying susceptibility to multifactorial disease. …

  Authors: Andrew T Hattersley, Mark I McCarthy

  Source: Lancet. 2005 Oct 8

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• Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels.

  We carried out a genome-wide association study of hemoglobin levels in 16,001 individuals of European and Indian Asian ancestry. The most closely asso…

  Authors: John C Chambers, Weihua Zhang, Yun Li, Joban Sehmi, Mark N Wass, Delilah Zabaneh, Clive Hoggart, Henry Bayele, Mark I McCarthy, Leena Peltonen,…

  Source: Nature genetics. 2009 Nov

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• Genome-wide association studies: potential next steps on a genetic journey.

  Genome-wide association studies have successfully identified numerous loci at which common variants influence disease risk or quantitative traits. Des…

  Authors: Mark I McCarthy, Joel N Hirschhorn

  Source: Human molecular genetics. 2008 Oct 15

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• Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.

  Genome-wide association studies (GWAS) of longitudinal birth cohorts enable joint investigation of environmental and genetic influences on complex tra…

  Authors: Chiara Sabatti, Susan K Service, Anna-Liisa Hartikainen, Anneli Pouta, Samuli Ripatti, Jae Brodsky, Chris G Jones, Noah A Zaitlen, Teppo Varilo, Marika Kaakinen,…

  Source: Nature genetics. 2009 Jan

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• A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.

  To identify genetic factors influencing quantitative traits of biomedical importance, we conducted a genome-wide association study in 8,842 samples fr…

  Authors: Yoon Shin Cho, Min Jin Go, Young Jin Kim, Jee Yeon Heo, Ji Hee Oh, Hyo-Jeong Ban, Dankyu Yoon, Mi Hee Lee, Dong-Joon Kim, Miey Park,…

  Source: Nature genetics. 2009 May

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• An evaluation of HapMap sample size and tagging SNP performance in large-scale empirical and simulated data sets.

  A substantial investment has been made in the generation of large public resources designed to enable the identification of tag SNP sets, but data est…

  Authors: Eleftheria Zeggini, William Rayner, Andrew P Morris, Andrew T Hattersley, Mark Walker, Graham A Hitman, Panos Deloukas, Lon R Cardon, Mark I McCarthy

  Source: Nature genetics. 2005 Dec

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