1 to 10 of 87 literature results

• CD98hc facilitates B cell proliferation and adaptive humoral immunity.

  The proliferation of antigen-specific lymphocytes and resulting clonal expansion are essential for adaptive immunity. We report here that B cell-speci…

  Authors: Joseph Cantor, Cecille D Browne, Raphael Ruppert, Chloé C Féral, Reinhard Fässler, Robert C Rickert, Mark H Ginsberg

  Source: Nature immunology. 2009 Apr

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• Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration.

  Cell migration is a dynamic process that requires temporal and spatial regulation of integrin activation and focal adhesion assembly/disassembly. Tali…

  Authors: Cai Huang, Zenon Rajfur, Nima Yousefi, Zaozao Chen, Ken Jacobson, Mark H Ginsberg

  Source: Nature cell biology. 2009 May

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• Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway.

  Cerebral cavernous malformations (CCMs) are human vascular malformations caused by mutations in three genes of unknown function: KRIT1, CCM2 and PDCD1…

  Authors: Benjamin Kleaveland, Xiangjian Zheng, Jian J Liu, Yannick Blum, Jennifer J Tung, Zhiying Zou, Shawn M Sweeney, Mei Chen, Lili Guo, Min-min Lu,…

  Source: Nature medicine. 2009 Feb

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• Structural basis of integrin activation by talin.

  Regulation of integrin affinity (activation) is essential for metazoan development and for many pathological processes. Binding of the talin phosphoty…

  Authors: Kate L Wegener, Anthony W Partridge, Jaewon Han, Andrew R Pickford, Robert C Liddington, Mark H Ginsberg, Iain D Campbell

  Source: Cell. 2007 Jan 12

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• Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha.

  Changes in cellular expression of phosphoprotein enriched in astrocytes of 15 kDa (PEA-15) are linked to insulin resistance, tumor cell invasion, and …

  Authors: Jacob R Haling, Fen Wang, Mark H Ginsberg

  Source: Molecular biology of the cell. 2010 Feb

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• Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability.

  The angiogenic sprout has been compared to the growing axon, and indeed, many proteins direct pathfinding by both structures. The Roundabout (Robo) pr…

  Authors: Christopher A Jones, Nyall R London, Haoyu Chen, Kye Won Park, Dominique Sauvaget, Rebecca A Stockton, Joshua D Wythe, Wonhee Suh, Frederic Larrieu-Lahargue, Yoh-Suke Mukouyama,…

  Source: Nature medicine. 2008 Apr

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• An alpha4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells.

  Formation of a stable lamellipodium at the front of migrating cells requires localization of Rac activation to the leading edge. Restriction of alpha4…

  Authors: Naoyuki Nishiya, William B Kiosses, Jaewon Han, Mark H Ginsberg

  Source: Nature cell biology. 2005 Apr

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• Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation.

  Clustering and occupancy of platelet integrin alpha(IIb)beta(3) (GPIIb-IIIa) generate biologically important signals: conversely, intracellular signal…

  Authors: Chungho Kim, Tong-Lay Lau, Tobias S Ulmer, Mark H Ginsberg

  Source: Blood. 2009 May 7

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• Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity.

  Slit-Roundabout (Robo) signalling has a well-understood role in axon guidance. Unlike in the nervous system, however, Slit-dependent activation of an …

  Authors: Christopher A Jones, Naoyuki Nishiya, Nyall R London, Weiquan Zhu, Lise K Sorensen, Aubrey C Chan, Chinten J Lim, Haoyu Chen, Qisheng Zhang, Peter G Schultz,…

  Source: Nature cell biology. 2009 Nov

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• Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets.

  alphaIIbbeta3 interaction with fibrinogen promotes Src-dependent platelet spreading in vitro. To determine the consequences of this outside-in signali…

  Authors: Ararat J Ablooglu, Jian Kang, Brian G Petrich, Mark H Ginsberg, Sanford J Shattil

  Source: Blood. 2009 Apr 9

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