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The proliferation of antigen-specific lymphocytes and resulting clonal expansion are essential for adaptive immunity. We report here that B cell-speci…
Authors: Joseph Cantor, Cecille D Browne, Raphael Ruppert, Chloé C Féral, Reinhard Fässler, Robert C Rickert, Mark H Ginsberg
Source: Nature immunology. 2009 Apr
View Free Full TextCell migration is a dynamic process that requires temporal and spatial regulation of integrin activation and focal adhesion assembly/disassembly. Tali…
Authors: Cai Huang, Zenon Rajfur, Nima Yousefi, Zaozao Chen, Ken Jacobson, Mark H Ginsberg
Source: Nature cell biology. 2009 May
View Free Full TextCerebral cavernous malformations (CCMs) are human vascular malformations caused by mutations in three genes of unknown function: KRIT1, CCM2 and PDCD1…
Authors: Benjamin Kleaveland, Xiangjian Zheng, Jian J Liu, Yannick Blum, Jennifer J Tung, Zhiying Zou, Shawn M Sweeney, Mei Chen, Lili Guo, Min-min Lu,…
Source: Nature medicine. 2009 Feb
View Free Full TextRegulation of integrin affinity (activation) is essential for metazoan development and for many pathological processes. Binding of the talin phosphoty…
Authors: Kate L Wegener, Anthony W Partridge, Jaewon Han, Andrew R Pickford, Robert C Liddington, Mark H Ginsberg, Iain D Campbell
Source: Cell. 2007 Jan 12
View Full TextChanges in cellular expression of phosphoprotein enriched in astrocytes of 15 kDa (PEA-15) are linked to insulin resistance, tumor cell invasion, and …
Authors: Jacob R Haling, Fen Wang, Mark H Ginsberg
Source: Molecular biology of the cell. 2010 Feb
View Full TextThe angiogenic sprout has been compared to the growing axon, and indeed, many proteins direct pathfinding by both structures. The Roundabout (Robo) pr…
Authors: Christopher A Jones, Nyall R London, Haoyu Chen, Kye Won Park, Dominique Sauvaget, Rebecca A Stockton, Joshua D Wythe, Wonhee Suh, Frederic Larrieu-Lahargue, Yoh-Suke Mukouyama,…
Source: Nature medicine. 2008 Apr
View Full TextFormation of a stable lamellipodium at the front of migrating cells requires localization of Rac activation to the leading edge. Restriction of alpha4…
Authors: Naoyuki Nishiya, William B Kiosses, Jaewon Han, Mark H Ginsberg
Source: Nature cell biology. 2005 Apr
View Full TextClustering and occupancy of platelet integrin alpha(IIb)beta(3) (GPIIb-IIIa) generate biologically important signals: conversely, intracellular signal…
Authors: Chungho Kim, Tong-Lay Lau, Tobias S Ulmer, Mark H Ginsberg
Source: Blood. 2009 May 7
View Full TextSlit-Roundabout (Robo) signalling has a well-understood role in axon guidance. Unlike in the nervous system, however, Slit-dependent activation of an …
Authors: Christopher A Jones, Naoyuki Nishiya, Nyall R London, Weiquan Zhu, Lise K Sorensen, Aubrey C Chan, Chinten J Lim, Haoyu Chen, Qisheng Zhang, Peter G Schultz,…
Source: Nature cell biology. 2009 Nov
View Full TextalphaIIbbeta3 interaction with fibrinogen promotes Src-dependent platelet spreading in vitro. To determine the consequences of this outside-in signali…
Authors: Ararat J Ablooglu, Jian Kang, Brian G Petrich, Mark H Ginsberg, Sanford J Shattil
Source: Blood. 2009 Apr 9
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