1 to 10 of 66 literature results

• The role of complement in the development of systemic lupus erythematosus.

  Complement has both beneficial and deleterious roles in the pathogenesis of systemic lupus erythematosus (SLE). On the one hand, patients with SLE pre…

  Authors: Anthony P Manderson, Marina Botto, Mark J Walport

  Source: Annual review of immunology. 2004

  View Full Text

• Dectin-1 is required for beta-glucan recognition and control of fungal infection.

  Beta-glucan is one of the most abundant polysaccharides in fungal pathogens, yet its importance in antifungal immunity is unclear. Here we show that d…

  Authors: Philip R Taylor, S Vicky Tsoni, Janet A Willment, Kevin M Dennehy, Marcela Rosas, Helen Findon, Ken Haynes, Chad Steele, Marina Botto, Siamon Gordon,…

  Source: Nature immunology. 2007 Jan

  View Free Full Text

• Immunoglobulin M is required for protection against atherosclerosis in low-density lipoprotein receptor-deficient mice.

  BACKGROUND: Immunoglobulin M (IgM) natural antibodies bind oxidatively-modified low-density lipoprotein (LDL) and apoptotic cells and have been implic…

  Authors: Myles J Lewis, Talat H Malik, Michael R Ehrenstein, Joseph J Boyle, Marina Botto, Dorian O Haskard

  Source: Circulation. 2009 Aug 4

  View Full Text

• Lack of effect of a single injection of human C-reactive protein on murine lupus or nephrotoxic nephritis.

  OBJECTIVE: It has been reported that a single dose of human C-reactive protein (CRP) can prevent and reverse the renal damage in murine models of spon…

  Authors: Francesco Carlucci, H Terence Cook, Abhilok Garg, Mark B Pepys, Marina Botto

  Source: Arthritis and rheumatism. 2010 Jan

  View Full Text

• C1q enhances IFN-gamma production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells.

  Dendritic cells (DCs) are known to produce C1q, the initiator of the classical complement pathway. We demonstrate that murine DCs deficient in C1q (C1…

  Authors: Paramita Baruah, Ingrid E Dumitriu, Talat H Malik, H Terence Cook, Julian Dyson, Diane Scott, Elizabeth Simpson, Marina Botto

  Source: Blood. 2009 Apr 9

  View Full Text

• Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses.

  CD8(+) T cells are essential for long-term, vaccine-induced resistance against intracellular pathogens. Here we show that natural antibodies, acting i…

  Authors: Simona Stäger, James Alexander, Alun C Kirby, Marina Botto, Nico Van Rooijen, Deborah F Smith, Frank Brombacher, Paul M Kaye

  Source: Nature medicine. 2003 Oct

  View Full Text

• Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H.

  The alternative pathway of complement is activated continuously in vivo through the C3 'tick-over' pathway. This pathway is triggered by the hydrolysi…

  Authors: Matthew C Pickering, H Terence Cook, Joanna Warren, Anne E Bygrave, Jill Moss, Mark J Walport, Marina Botto

  Source: Nature genetics. 2002 Aug

  View Full Text

• Regulation of B cell tolerance by 129-derived chromosome 1 loci in C57BL/6 mice.

  OBJECTIVE: Systemic lupus erythematosus is a multifactorial disease with a strong genetic component. Previous studies have shown that a 129-derived ch…

  Authors: Liliane Fossati-Jimack, Josefina Cortes-Hernandez, Peter J Norsworthy, H Terence Cook, Mark J Walport, Marina Botto

  Source: Arthritis and rheumatism. 2008 Jul

  View Full Text

• Phosphatidylserine receptor and apoptosis: consequences of a non-ingested meal.

  Apoptosis, a physiological process of controlled cell death, is essential during embryonic development and for the maintenance of tissue homeostasis. …

  Authors: Marina Botto

  Source: Arthritis research & therapy. 2004

  View Full Text

• Complement C3 plays an essential role in the control of opportunistic fungal infections.

  The innate recognition of fungal pathogens is a crucial first step in the induction of protective antifungal immunity. Complement is thought to be one…

  Authors: S Vicky Tsoni, Ann M Kerrigan, Mohlopheni J Marakalala, Naren Srinivasan, Maureen Duffield, Philip R Taylor, Marina Botto, Chad Steele, Gordon D Brown

  Source: Infection and immunity. 2009 Sep

  View Free Full Text