1 to 10 of 13 literature results

• Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers.

  Basal-like breast cancers arising in women carrying mutations in the BRCA1 gene, encoding the tumor suppressor protein BRCA1, are thought to develop f…

  Authors: Elgene Lim, François Vaillant, Di Wu, Natasha C Forrest, Bhupinder Pal, Adam H Hart, Marie-Liesse Asselin-Labat, David E Gyorki, Teresa Ward, Audrey Partanen,…

  Source: Nature medicine. 2009 Aug

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• Generation of a functional mammary gland from a single stem cell.

  The existence of mammary stem cells (MaSCs) has been postulated from evidence that the mammary gland can be regenerated by transplantation of epitheli…

  Authors: Mark Shackleton, François Vaillant, Kaylene J Simpson, John Stingl, Gordon K Smyth, Marie-Liesse Asselin-Labat, Li Wu, Geoffrey J Lindeman, Jane E Visvader

  Source: Nature. 2006 Jan 5

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• Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation.

  The transcription factor Gata-3 is a defining marker of the 'luminal' subtypes of breast cancer. To gain insight into the role of Gata-3 in breast epi…

  Authors: Marie-Liesse Asselin-Labat, Kate D Sutherland, Holly Barker, Richard Thomas, Mark Shackleton, Natasha C Forrest, Lynne Hartley, Lorraine Robb, Frank G Grosveld, Jacqueline van der Wees,…

  Source: Nature cell biology. 2007 Feb

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• The Ets transcription factor Elf5 specifies mammary alveolar cell fate.

  Hormonal cues regulate mammary development, but the consequent transcriptional changes and cell fate decisions are largely undefined. We show that kno…

  Authors: Samantha R Oakes, Matthew J Naylor, Marie-Liesse Asselin-Labat, Katrina D Blazek, Margaret Gardiner-Garden, Heidi N Hilton, Michael Kazlauskas, Melanie A Pritchard, Lewis A Chodosh, Peter L Pfeffer,…

  Source: Genes & development. 2008 Mar 1

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• The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis.

  The cells of origin and mechanisms that underpin tumor heterogeneity in breast cancer are poorly understood. Here, we have examined three mouse models…

  Authors: François Vaillant, Marie-Liesse Asselin-Labat, Mark Shackleton, Natasha C Forrest, Geoffrey J Lindeman, Jane E Visvader

  Source: Cancer research. 2008 Oct 1

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• Steroid hormone receptor status of mouse mammary stem cells.

  The estrogen receptor alpha (ERalpha), progesterone receptor (PR), and erbB2 (Her2 in humans) are important prognostic markers of human breast cancer,…

  Authors: Marie-Liesse Asselin-Labat, Mark Shackleton, John Stingl, François Vaillant, Natasha C Forrest, Connie J Eaves, Jane E Visvader, Geoffrey J Lindeman

  Source: Journal of the National Cancer Institute. 2006 Jul 19

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• GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis.

  Interleukin-2 (IL-2) withdrawal is a physiologic process inducing cell death in activated T lymphocytes. Glucocorticoid-induced leucine zipper (GILZ) …

  Authors: Marie-Liesse Asselin-Labat, Muriel David, Armelle Biola-Vidamment, Damiana Lecoeuche, Maria-Christina Zennaro, Jacques Bertoglio, Marc Pallardy

  Source: Blood. 2004 Jul 1

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• Resident macrophages influence stem cell activity in the mammary gland.

  INTRODUCTION : Macrophages in the mammary gland are essential for morphogenesis of the ductal epithelial tree and have been implicated in promoting br…

  Authors: David E Gyorki, Marie-Liesse Asselin-Labat, Nico van Rooijen, Geoffrey J Lindeman, Jane E Visvader

  Source: Breast cancer research : BCR. 2009

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• Notch signaling regulates mammary stem cell function and luminal cell-fate commitment.

  The recent identification of mouse mammary stem cells (MaSCs) and progenitor subpopulations has enhanced the prospect of investigating the genetic con…

  Authors: Toula Bouras, Bhupinder Pal, François Vaillant, Gwyndolen Harburg, Marie-Liesse Asselin-Labat, Samantha R Oakes, Geoffrey J Lindeman, Jane E Visvader

  Source: Cell stem cell. 2008 Oct 9

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• The emerging picture of the mouse mammary stem cell.

  The isolation and characterisation of mammary stem cells is an important step towards elucidating the hierarchy of epithelial cell development in the …

  Authors: François Vaillant, Marie-Liesse Asselin-Labat, Mark Shackleton, Geoffrey J Lindeman, Jane E Visvader

  Source: Stem cell reviews. 2007 Jun

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