1 to 10 of 17 literature results

• The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences.

  The expression of many genes involved in xenobiotic/drug metabolism and transport is regulated by at least three nuclear receptors or xenosensors: ary…

  Authors: Jean-Marc Pascussi, Sabine Gerbal-Chaloin, Cédric Duret, Martine Daujat-Chavanieu, Marie-José Vilarem, Patrick Maurel

  Source: Annual review of pharmacology and toxicology. 2008

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• Hepatic Expression of Thyroid Hormone-Responsive Spot 14 Protein Is Regulated by Constitutive Androstane Receptor (NR1I3).

  The pregnane X receptors (PXRs) and the constitutive androstane receptor (CAR) were initially isolated as nuclear receptors regulating xenobiotic meta…

  Authors: Cyril Breuker, Amélie Moreau, Laila Lakhal, Viola Tamasi, Yannick Parmentier, Urs Meyer, Patrick Maurel, Serge Lumbroso, Marie-José Vilarem, Jean-Marc Pascussi

  Source: Endocrinology. 2010 Feb 25

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• Identification of proteomic changes during human liver development by 2D-DIGE and mass spectrometry.

  BACKGROUND/AIMS: The aim of this study was to identify human liver proteins that are associated with different stages of liver development. METHODS: W…

  Authors: Jean Paul Brizard, Jeanne Ramos, Agnés Robert, Daniel Lafitte, Nicole Bigi, Pierre Sarda, Dalila Laoudj-Chenivesse, Francis Navarro, Pierre Blanc, Eric Assenat,…

  Source: Journal of hepatology. 2009 Jul

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• Constitutive androstane receptor-vitamin D receptor crosstalk: consequence on CYP24 gene expression.

  We previously reported that the pregnane X receptor (PXR) interferes with vitamin D receptor (VDR) target genes, notably CYP24, by targeting the same …

  Authors: Amélie Moreau, Patrick Maurel, Marie-José Vilarem, Jean-Marc Pascussi

  Source: Biochemical and biophysical research communications. 2007 Aug 17

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• Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor.

  The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) play a major part in the control of drug metabolism and transport. We hav…

  Authors: Cedric Duret, Martine Daujat-Chavanieu, Jean-Marc Pascussi, Lydiane Pichard-Garcia, Patrick Balaguer, Jean-Michel Fabre, Marie-José Vilarem, Patrick Maurel, Sabine Gerbal-Chaloin

  Source: Molecular pharmacology. 2006 Jul

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• Pathophysiological factors affecting CAR gene expression.

  The body defends itself against potentially harmful compounds, such as drugs and toxic endogenous compounds and their metabolites, by inducing the exp…

  Authors: Jean Marc Pascussi, Zdenek Dvorák, Sabine Gerbal-Chaloin, Eric Assenat, Patrick Maurel, Marie José Vilarem

  Source: Drug metabolism reviews. 2003 Nov

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• Inflammation and drug metabolism: NF-kappB and the CAR and PXR xeno-receptors

  Decreased drug metabolism, hyperbilirubinemia and intrahepatic cholestasis are frequently observed during inflammation. Additionally, it has long been…

  Authors: Jean-Marc Pascussi, Marie-José Vilarem

  Source: Médecine sciences : M/S. 2008 Mar

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• Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response.

  Xenobiotic and drug metabolism and transport are managed by a large number of genes coordinately regulated by at least three nuclear receptors or xeno…

  Authors: Amélie Moreau, Marie José Vilarem, Patrick Maurel, Jean Marc Pascussi

  Source: Molecular pharmaceutics. 2008 Jan-Feb

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• Is nuclear factor kappa-B the missing link between inflammation, cancer and alteration in hepatic drug metabolism in patients with cancer?

  In the last few years, several studies have provided a causal link between constitutive activation of nuclear factor kappa-B (NF-kappaB) and the initi…

  Authors: Eric Assenat, Sabine Gerbal-chaloin, Patrick Maurel, Marie José Vilarem, Jean Marc Pascussi

  Source: European journal of cancer (Oxford, England : 1990). 2006 Apr

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• A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte.

  The pregnane X receptor (PXR) initially isolated as a nuclear receptor regulating xenobiotic and drug metabolism and elimination, seems to play an end…

  Authors: Amélie Moreau, Christelle Téruel, Michel Beylot, Valérie Albalea, Viola Tamasi, Thierry Umbdenstock, Yannick Parmentier, Antonio Sa-Cunha, Bertrand Suc, Jean-Michel Fabre,…

  Source: Hepatology (Baltimore, Md.). 2009 Jun

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