10 literature results

• Identification of loci associated with schizophrenia by genome-wide association and follow-up.

  We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional…

  Authors: Michael C O'Donovan, Nicholas Craddock, Nadine Norton, Hywel Williams, Timothy Peirce, Valentina Moskvina, Ivan Nikolov, Marian Hamshere, Liam Carroll, Lyudmila Georgieva,…

  Source: Nature genetics. 2008 Sep

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• Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder.

  CONTEXT: Variation at the DAOA/G30 locus has been described to be associated with both schizophrenia and bipolar disorder, but there is little consist…

  Authors: Nigel M Williams, Elaine K Green, Stuart Macgregor, Sarah Dwyer, Nadine Norton, Hywel Williams, Rachel Raybould, Detelina Grozeva, Marian Hamshere, Stanley Zammit,…

  Source: Archives of general psychiatry. 2006 Apr

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• Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder.

  CONTEXT: Family and twin data suggest that, in addition to susceptibility genes specific for bipolar disorder or schizophrenia, genes exist that contr…

  Authors: Elaine K Green, Rachel Raybould, Stuart Macgregor, Katherine Gordon-Smith, Jess Heron, Sally Hyde, Detelina Grozeva, Marian Hamshere, Nigel Williams, Michael J Owen,…

  Source: Archives of general psychiatry. 2005 Jun

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• Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q.

  Several independent studies and meta-analyses aimed at identifying genomic regions linked to bipolar disorder (BP) have failed to find clear and consi…

  Authors: Matthew B McQueen, B Devlin, Stephen V Faraone, Vishwajit L Nimgaonkar, Pamela Sklar, Jordan W Smoller, Rami Abou Jamra, Margot Albus, Silviu-Alin Bacanu, Miron Baron,…

  Source: American journal of human genetics. 2005 Oct

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• Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin.

  Authors: Sven Cichon, Silvia Buervenich, George Kirov, Nirmala Akula, Albena Dimitrova, Elaine Green, Johannes Schumacher, Norman Klopp, Tim Becker, Stephanie Ohlraun,…

  Source: Nature genetics. 2004 Aug

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• Full genome screen for Alzheimer disease: stage II analysis.

  We performed a two-stage genome screen to search for novel risk factors for late-onset Alzheimer disease (AD). The first stage involved genotyping 292…

  Authors: Amanda Myers, Fabienne Wavrant De-Vrieze, Peter Holmans, Marian Hamshere, Richard Crook, Danielle Compton, Helen Marshall, David Meyer, Shantia Shears, Jeremy Booth,…

  Source: American journal of medical genetics. 2002 Mar 8

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• Bipolar affective puerperal psychosis: genome-wide significant evidence for linkage to chromosome 16.

  OBJECTIVE: Vulnerability to the triggering of bipolar episodes by childbirth aggregates in families and may define a genetically relevant subtype of b…

  Authors: Ian Jones, Marian Hamshere, Jeanne-Marrie Nangle, Philip Bennett, Elaine Green, Jess Heron, Ricardo Segurado, David Lambert, Peter Holmans, Aiden Corvin,…

  Source: The American journal of psychiatry. 2007 Jul

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• Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease.

  We performed an affected sib-pair (ASP) linkage analysis to test for the effects of age at onset (AAO), rate of decline (ROD), and Apolipoprotein E (A…

  Authors: Peter Holmans, Marian Hamshere, Paul Hollingworth, Frances Rice, Nigel Tunstall, Sue Jones, Pamela Moore, Fabienne Wavrant DeVrieze, Amanda Myers, Richard Crook,…

  Source: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2005 May 5

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• Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.

  Linkage studies have suggested there is a susceptibility gene for late onset Alzheimer's disease (LOAD) in a broad region of chromosome 10. A strong p…

  Authors: Petra Nowotny, Anthony L Hinrichs, Scott Smemo, John S K Kauwe, Taylor Maxwell, Peter Holmans, Marian Hamshere, Dragana Turic, Luke Jehu, Paul Hollingworth,…

  Source: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2005 Jul 5

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• Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.

  Linkage studies indicate that the same region of chromosome 10 contains a risk locus for late onset Alzheimer disease (LOAD) and a QTL for plasma Abet…

  Authors: Amanda J Myers, Helen Marshall, Peter Holmans, Danielle Compton, Richard J P Crook, Adrian P Mander, Petra Nowotny, Scott Smemo, Melanie Dunstan, Luke Jehu,…

  Source: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2004 Jan 1

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