1 to 6 of 6 literature results

• Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties.

  Notch signaling is an area of great interest in oncology. RO4929097 is a potent and selective inhibitor of gamma-secretase, producing inhibitory activ…

  Authors: Leopoldo Luistro, Wei He, Melissa Smith, Kathryn Packman, Maria Vilenchik, Daisy Carvajal, John Roberts, James Cai, Windy Berkofsky-Fessler, Holly Hilton,…

  Source: Cancer research. 2009 Oct 1

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• Hsp90: the vulnerable chaperone.

  The molecular chaperone Hsp90 has emerged as an important target in cancer treatment because of its roles in maintaining transformation and regulating…

  Authors: Gabriela Chiosis, Maria Vilenchik, Joungnam Kim, David Solit

  Source: Drug discovery today. 2004 Oct 15

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• Microtiter cell-based assay for detection of agents that alter cellular levels of Her2 and EGFR.

  Overexpression of the transmembrane tyrosine kinases Her2 and EGFR is associated with aggressive malignancies, and several therapeutic strategies targ…

  Authors: Henri Huezo, Maria Vilenchik, Neal Rosen, Gabriela Chiosis

  Source: Chemistry & biology. 2003 Jul

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• Antisense RNA down-regulation of bcl-xL Expression in prostate cancer cells leads to diminished rates of cellular proliferation and resistance to cytotoxic chemotherapeutic agents.

  bcl-xL is a M(r) 26,000 bcl-2 homologue that is highly expressed in prostate cancer cells. In previous studies, the down-regulation of its expression …

  Authors: Maria Vilenchik, Anthony J Raffo, Luba Benimetskaya, David Shames, C A Stein

  Source: Cancer research. 2002 Apr 1

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• Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.

  Agents that inhibit Hsp90 function hold significant promise in cancer therapy. Here we present PU24FCl, a representative of the first class of designe…

  Authors: Maria Vilenchik, David Solit, Andrea Basso, Henri Huezo, Brian Lucas, Huazhong He, Neal Rosen, Claudia Spampinato, Paul Modrich, Gabriela Chiosis

  Source: Chemistry & biology. 2004 Jun

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• Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.

  The heat shock protein 90 (Hsp90) has a critical role in malignant transformation. Whereas its ability to maintain the functional conformations of mut…

  Authors: Anna Rodina, Maria Vilenchik, Kamalika Moulick, Julia Aguirre, Joungnam Kim, Anne Chiang, Julie Litz, Cristina C Clement, Yanlong Kang, Yuhong She,…

  Source: Nature chemical biology. 2007 Aug

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