1 to 6 of 6 literature results

• TMPRSS2-ERG gene fusion is not associated with outcome in patients treated by prostatectomy.

  A significant number of prostate cancers have been shown to have recurrent chromosomal rearrangements resulting in the fusion of the androgen-regulate…

  Authors: Anuradha Gopalan, Margaret A Leversha, Jaya M Satagopan, Qin Zhou, Hikmat A Al-Ahmadie, Samson W Fine, James A Eastham, Peter T Scardino, Howard I Scher, Satish K Tickoo,…

  Source: Cancer research. 2009 Feb 15

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• Fluorescence in situ hybridization analysis of circulating tumor cells in metastatic prostate cancer.

  PURPOSE: To assess the feasibility of characterizing gene copy number alteration by fluorescence in situ hybridization (FISH) of circulating tumor cel…

  Authors: Margaret A Leversha, Jialian Han, Zahra Asgari, Daniel C Danila, Oscar Lin, Rita Gonzalez-Espinoza, Aseem Anand, Hans Lilja, Glenn Heller, Martin Fleisher,…

  Source: Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 Mar 15

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• Transcriptome-guided characterization of genomic rearrangements in a breast cancer cell line.

  We have identified new genomic alterations in the breast cancer cell line HCC1954, using high-throughput transcriptome sequencing. With 120 Mb of cDNA…

  Authors: Qi Zhao, Otavia L Caballero, Samuel Levy, Brian J Stevenson, Christian Iseli, Sandro J de Souza, Pedro A Galante, Dana Busam, Margaret A Leversha, Kalyani Chadalavada,…

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2009 Feb 10

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• DNA copy number analysis in gastrointestinal stromal tumors using gene expression microarrays.

  We report a method, Expression-Microarray Copy Number Analysis (ECNA) for the detection of copy number changes using Affymetrix Human Genome U133 Plus…

  Authors: Cristina R Antonescu, Kai Wu, Guoliang Leon Xing, Manqiu Cao, Yaron Turpaz, Margaret A Leversha, Earl Hubbell, Robert G Maki, C Garrett Miyada, Raji Pillai

  Source: Cancer informatics. 2008

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• Circulating tumor cell analysis in patients with progressive castration-resistant prostate cancer.

  PURPOSE: To better direct targeted therapies to the patients with tumors that express the target, there is an urgent need for blood-based assays that …

  Authors: David R Shaffer, Margaret A Leversha, Daniel C Danila, Oscar Lin, Rita Gonzalez-Espinoza, Bin Gu, Aseem Anand, Katherine Smith, Peter Maslak, Gerald V Doyle,…

  Source: Clinical cancer research : an official journal of the American Association for Cancer Research. 2007 Apr 1

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• Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation.

  Most gastrointestinal stromal tumors (GIST) have an activating mutation in either KIT or PDGFRA. Imatinib is a selective tyrosine kinase inhibitor and…

  Authors: Cristina R Antonescu, Peter Besmer, Tianhua Guo, Knarik Arkun, Glory Hom, Beata Koryotowski, Margaret A Leversha, Philip D Jeffrey, Diann Desantis, Samuel Singer,…

  Source: Clinical cancer research : an official journal of the American Association for Cancer Research. 2005 Jun 1

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