1 to 10 of 23 literature results

• Common variants in TMPRSS6 are associated with iron status and erythrocyte volume.

  We report a genome-wide association study to iron status. We identify an association of SNPs in TPMRSS6 to serum iron (rs855791, combined P = 1.5 x 10…

  Authors: Beben Benyamin, Manuel A R Ferreira, Gonneke Willemsen, Scott Gordon, Rita P S Middelberg, Brian P McEvoy, Jouke-Jan Hottenga, Anjali K Henders, Megan J Campbell, Leanne Wallace,…

  Source: Nature genetics. 2009 Nov

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• Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder.

  We present a method for testing overrepresentation of biological pathways, indexed by gene-ontology terms, in lists of significant SNPs from genome-wi…

  Authors: Peter Holmans, Elaine K Green, Jaspreet Singh Pahwa, Manuel A R Ferreira, Shaun M Purcell, Pamela Sklar, Wellcome Trust Case-Control Consortium, Michael J Owen, Michael C O'Donovan, Nick Craddock

  Source: American journal of human genetics. 2009 Jul

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• Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control.

  Abnormal expansion or depletion of particular lymphocyte subsets is associated with clinical manifestations such as HIV progression to AIDS and autoim…

  Authors: Manuel A R Ferreira, Massimo Mangino, Chanson J Brumme, Zhen Zhen Zhao, Sarah E Medland, Margaret J Wright, Dale R Nyholt, Scott Gordon, Megan Campbell, Brian P McEvoy,…

  Source: American journal of human genetics. 2010 Jan

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• Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

  To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of stro…

  Authors: Manuel A R Ferreira, Michael C O'Donovan, Yan A Meng, Ian R Jones, Douglas M Ruderfer, Lisa Jones, Jinbo Fan, George Kirov, Roy H Perlis, Elaine K Green,…

  Source: Nature genetics. 2008 Sep

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• Practical aspects of imputation-driven meta-analysis of genome-wide association studies.

  Motivated by the overwhelming success of genome-wide association studies, droves of researchers are working vigorously to exchange and to combine gene…

  Authors: Paul I W de Bakker, Manuel A R Ferreira, Xiaoming Jia, Benjamin M Neale, Soumya Raychaudhuri, Benjamin F Voight

  Source: Human molecular genetics. 2008 Oct 15

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• Sequence variants in three loci influence monocyte counts and erythrocyte volume.

  Blood cells participate in vital physiological processes, and their numbers are tightly regulated so that homeostasis is maintained. Disruption of key…

  Authors: Manuel A R Ferreira, Jouke-Jan Hottenga, Nicole M Warrington, Sarah E Medland, Gonneke Willemsen, Robert W Lawrence, Scott Gordon, Eco J C de Geus, Anjali K Henders, Johannes H Smit,…

  Source: American journal of human genetics. 2009 Nov

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• Common variants in the trichohyalin gene are associated with straight hair in Europeans.

  Hair morphology is highly differentiated between populations and among people of European ancestry. Whereas hair morphology in East Asian populations …

  Authors: Sarah E Medland, Dale R Nyholt, Jodie N Painter, Brian P McEvoy, Allan F McRae, Gu Zhu, Scott D Gordon, Manuel A R Ferreira, Margaret J Wright, Anjali K Henders,…

  Source: American journal of human genetics. 2009 Nov

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• PLINK: a tool set for whole-genome association and population-based linkage analyses.

  Whole-genome association studies (WGAS) bring new computational, as well as analytic, challenges to researchers. Many existing genetic-analysis tools …

  Authors: Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly,…

  Source: American journal of human genetics. 2007 Sep

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• Genomewide significant linkage to migrainous headache on chromosome 5q21.

  Familial typical migraine is a common, complex disorder that shows strong familial aggregation. Using latent-class analysis (LCA), we identified subgr…

  Authors: Dale R Nyholt, Katherine I Morley, Manuel A R Ferreira, Sarah E Medland, Dorret I Boomsma, Andrew C Heath, Kathleen R Merikangas, Grant W Montgomery, Nicholas G Martin

  Source: American journal of human genetics. 2005 Sep

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• Robust estimation of experimentwise P values applied to a genome scan of multiple asthma traits identifies a new region of significant linkage on chromosome 20q13.

  Over 30 genomic regions show linkage to asthma traits. Six asthma genes have been cloned, but the putative loci in many linked regions have not been i…

  Authors: Manuel A R Ferreira, Louise O'Gorman, Peter Le Souëf, Paul R Burton, Brett G Toelle, Colin F Robertson, Peter M Visscher, Nicholas G Martin, David L Duffy

  Source: American journal of human genetics. 2005 Dec

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