1 to 10 of 12 literature results

• Mammalian nicotinic acetylcholine receptors: from structure to function.

  The classical studies of nicotine by Langley at the turn of the 20th century introduced the concept of a "receptive substance," from which the idea of…

  Authors: Edson X Albuquerque, Edna F R Pereira, Manickavasagom Alkondon, Scott W Rogers

  Source: Physiological reviews. 2009 Jan

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• Age-dependent changes in the functional expression of two nicotinic receptor subtypes in CA1 stratum radiatum interneurons in the rat hippocampus.

  Protein density measurements and mRNA analysis have provided valuable information on age-dependent changes in the distribution of different nicotinic …

  Authors: Manickavasagom Alkondon, Edna F R Pereira, Edson X Albuquerque

  Source: Biochemical pharmacology. 2007 Oct 15

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• Strain-specific nicotinic modulation of glutamatergic transmission in the CA1 field of the rat hippocampus: August Copenhagen Irish versus Sprague-Dawley.

  Prepulse inhibition (PPI), a measure of sensorimotor gating impaired in patients with schizophrenia, is more sensitive to disruption by apomorphine in…

  Authors: Manickavasagom Alkondon, Edna F R Pereira, Michelle C Potter, Frederick C Kauffman, Robert Schwarcz, Edson X Albuquerque

  Source: Journal of neurophysiology. 2007 Feb

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• The nicotinic acetylcholine receptor subtypes and their function in the hippocampus and cerebral cortex.

  Nicotinic acetylcholine receptors (nAChRs) are widely distributed in the central nervous system and have been implicated in multiple behavioral paradi…

  Authors: Manickavasagom Alkondon, Edson X Albuquerque

  Source: Progress in brain research. 2004

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• NMDA and AMPA receptors contribute to the nicotinic cholinergic excitation of CA1 interneurons in the rat hippocampus.

  In the hippocampus, glutamatergic inputs to pyramidal neurons and interneurons are modulated by alpha7* and alpha3beta4* nicotinic acetylcholine recep…

  Authors: Manickavasagom Alkondon, Edna F R Pereira, Edson X Albuquerque

  Source: Journal of neurophysiology. 2003 Sep

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• A non-alpha7 nicotinic acetylcholine receptor modulates excitatory input to hippocampal CA1 interneurons.

  The nicotinic acetylcholine receptor (nAChR), particularly the alpha7 subtype, has received profound attention for its role in modifying excitatory po…

  Authors: Manickavasagom Alkondon, Edson X Albuquerque

  Source: Journal of neurophysiology. 2002 Mar

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• The nicotinic allosteric potentiating ligand galantamine facilitates synaptic transmission in the mammalian central nervous system.

  In this study, the patch-clamp technique was used to determine the effects of galantamine, a cholinesterase inhibitor and a nicotinic allosteric poten…

  Authors: Máriton D Santos, Manickavasagom Alkondon, Edna F R Pereira, Yasco Aracava, Howard M Eisenberg, Alfred Maelicke, Edson X Albuquerque

  Source: Molecular pharmacology. 2002 May

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• Molecular and cellular actions of galantamine: clinical implications for treatment of organophosphorus poisoning.

  There have been continued efforts to develop effective antidotal therapies against poisoning with organophosphorus (OP) compounds, including nerve age…

  Authors: Edna F R Pereira, Yasco Aracava, Manickavasagom Alkondon, Miriam Akkerman, Istvan Merchenthaler, Edson X Albuquerque

  Source: Journal of molecular neuroscience : MN. 2010 Jan

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• A single in vivo application of cholinesterase inhibitors has neuron type-specific effects on nicotinic receptor activity in guinea pig hippocampus.

  The present study was designed to test the hypothesis that an acute in vivo treatment with reversible or irreversible acetylcholinesterase (AChE) inhi…

  Authors: Manickavasagom Alkondon, Yasco Aracava, Edna F R Pereira, Edson X Albuquerque

  Source: The Journal of pharmacology and experimental therapeutics. 2009 Jan

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• Unconventional ligands and modulators of nicotinic receptors.

  Evidence gathered from epidemiologic and behavioral studies have indicated that neuronal nicotinic receptors (nAChRs) are intimately involved in the p…

  Authors: Edna F R Pereira, Corey Hilmas, Mariton D Santos, Manickavasagom Alkondon, Alfred Maelicke, Edson X Albuquerque

  Source: Journal of neurobiology. 2002 Dec

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