1 to 7 of 7 literature results

• ChIP-seq accurately predicts tissue-specific activity of enhancers.

  A major yet unresolved quest in decoding the human genome is the identification of the regulatory sequences that control the spatial and temporal expr…

  Authors: Axel Visel, Matthew J Blow, Zirong Li, Tao Zhang, Jennifer A Akiyama, Amy Holt, Ingrid Plajzer-Frick, Malak Shoukry, Crystal Wright, Feng Chen,…

  Source: Nature. 2009 Feb 12

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• Ultraconservation identifies a small subset of extremely constrained developmental enhancers.

  Extended perfect human-rodent sequence identity of at least 200 base pairs (ultraconservation) is potentially indicative of evolutionary or functional…

  Authors: Axel Visel, Shyam Prabhakar, Jennifer A Akiyama, Malak Shoukry, Keith D Lewis, Amy Holt, Ingrid Plajzer-Frick, Veena Afzal, Edward M Rubin, Len A Pennacchio

  Source: Nature genetics. 2008 Feb

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• In vivo enhancer analysis of human conserved non-coding sequences.

  Identifying the sequences that direct the spatial and temporal expression of genes and defining their function in vivo remains a significant challenge…

  Authors: Len A Pennacchio, Nadav Ahituv, Alan M Moses, Shyam Prabhakar, Marcelo A Nobrega, Malak Shoukry, Simon Minovitsky, Inna Dubchak, Amy Holt, Keith D Lewis,…

  Source: Nature. 2006 Nov 23

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• Close sequence comparisons are sufficient to identify human cis-regulatory elements.

  Cross-species DNA sequence comparison is the primary method used to identify functional noncoding elements in human and other large genomes. However, …

  Authors: Shyam Prabhakar, Francis Poulin, Malak Shoukry, Veena Afzal, Edward M Rubin, Olivier Couronne, Len A Pennacchio

  Source: Genome research. 2006 Jul

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• Functional autonomy of distant-acting human enhancers.

  Many human genes are associated with dispersed arrays of transcriptional enhancers that regulate their expression in time and space. Studies in invert…

  Authors: Axel Visel, Jennifer A Akiyama, Malak Shoukry, Veena Afzal, Edward M Rubin, Len A Pennacchio

  Source: Genomics. 2009 Jun

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• Human-specific gain of function in a developmental enhancer.

  Changes in gene regulation are thought to have contributed to the evolution of human development. However, in vivo evidence for uniquely human develop…

  Authors: Shyam Prabhakar, Axel Visel, Jennifer A Akiyama, Malak Shoukry, Keith D Lewis, Amy Holt, Ingrid Plajzer-Frick, Harris Morrison, David R Fitzpatrick, Veena Afzal,…

  Source: Science (New York, N.Y.). 2008 Sep 5

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• Comparative genomic analysis reveals a distant liver enhancer upstream of the COUP-TFII gene.

  COUP-TFII is a central nuclear hormone receptor that tightly regulates the expression of numerous target lipid metabolism genes in vertebrates. Howeve…

  Authors: Nadine Baroukh, Nadav Ahituv, Jessie Chang, Malak Shoukry, Veena Afzal, Edward M Rubin, Len A Pennacchio

  Source: Mammalian genome : official journal of the International Mammalian Genome Society. 2005 Feb

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