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A major yet unresolved quest in decoding the human genome is the identification of the regulatory sequences that control the spatial and temporal expr…
Authors: Axel Visel, Matthew J Blow, Zirong Li, Tao Zhang, Jennifer A Akiyama, Amy Holt, Ingrid Plajzer-Frick, Malak Shoukry, Crystal Wright, Feng Chen,…
Source: Nature. 2009 Feb 12
View Free Full TextExtended perfect human-rodent sequence identity of at least 200 base pairs (ultraconservation) is potentially indicative of evolutionary or functional…
Authors: Axel Visel, Shyam Prabhakar, Jennifer A Akiyama, Malak Shoukry, Keith D Lewis, Amy Holt, Ingrid Plajzer-Frick, Veena Afzal, Edward M Rubin, Len A Pennacchio
Source: Nature genetics. 2008 Feb
View Free Full TextIdentifying the sequences that direct the spatial and temporal expression of genes and defining their function in vivo remains a significant challenge…
Authors: Len A Pennacchio, Nadav Ahituv, Alan M Moses, Shyam Prabhakar, Marcelo A Nobrega, Malak Shoukry, Simon Minovitsky, Inna Dubchak, Amy Holt, Keith D Lewis,…
Source: Nature. 2006 Nov 23
View Full TextCross-species DNA sequence comparison is the primary method used to identify functional noncoding elements in human and other large genomes. However, …
Authors: Shyam Prabhakar, Francis Poulin, Malak Shoukry, Veena Afzal, Edward M Rubin, Olivier Couronne, Len A Pennacchio
Source: Genome research. 2006 Jul
View Free Full TextMany human genes are associated with dispersed arrays of transcriptional enhancers that regulate their expression in time and space. Studies in invert…
Authors: Axel Visel, Jennifer A Akiyama, Malak Shoukry, Veena Afzal, Edward M Rubin, Len A Pennacchio
Source: Genomics. 2009 Jun
View Full TextChanges in gene regulation are thought to have contributed to the evolution of human development. However, in vivo evidence for uniquely human develop…
Authors: Shyam Prabhakar, Axel Visel, Jennifer A Akiyama, Malak Shoukry, Keith D Lewis, Amy Holt, Ingrid Plajzer-Frick, Harris Morrison, David R Fitzpatrick, Veena Afzal,…
Source: Science (New York, N.Y.). 2008 Sep 5
View Free Full TextCOUP-TFII is a central nuclear hormone receptor that tightly regulates the expression of numerous target lipid metabolism genes in vertebrates. Howeve…
Authors: Nadine Baroukh, Nadav Ahituv, Jessie Chang, Malak Shoukry, Veena Afzal, Edward M Rubin, Len A Pennacchio
Source: Mammalian genome : official journal of the International Mammalian Genome Society. 2005 Feb
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