1 to 10 of 74 literature results

• Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

  Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Stu…

  Authors: Masato Furuhashi, Gürol Tuncman, Cem Z Görgün, Liza Makowski, Genichi Atsumi, Eric Vaillancourt, Keita Kono, Vladimir R Babaev, Sergio Fazio, MacRae F Linton,…

  Source: Nature. 2007 Jun 21

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• Fenofibrate and risk of minor amputations in diabetes.

  Authors: Sergio Fazio, MacRae F Linton

  Source: Lancet. 2009 May 23

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• Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse.

  Macrophage low-density lipoprotein receptor-related protein (LRP) mediates internalization of remnant lipoproteins, and it is generally thought that b…

  Authors: Cheryl D Overton, Patricia G Yancey, Amy S Major, MacRae F Linton, Sergio Fazio

  Source: Circulation research. 2007 Mar 16

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• Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor.

  Low-density lipoprotein receptor-related protein (LRP-1) functions in endocytosis and in cell signaling directly (by binding signaling adaptor protein…

  Authors: Alban Gaultier, Sanja Arandjelovic, Sherry Niessen, Cheryl D Overton, MacRae F Linton, Sergio Fazio, W Marie Campana, Benjamin F Cravatt, Steven L Gonias

  Source: Blood. 2008 Jun 1

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• Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.

  BACKGROUND: The peroxisome proliferator-activated receptor-alpha (PPARalpha) plays important roles in lipid metabolism, inflammation, and atherosclero…

  Authors: Vladimir R Babaev, Hiroyuki Ishiguro, Lei Ding, Patricia G Yancey, Dwayne E Dove, William J Kovacs, Clay F Semenkovich, Sergio Fazio, MacRae F Linton

  Source: Circulation. 2007 Sep 18

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• Retention of low-density lipoprotein in atherosclerotic lesions of the mouse: evidence for a role of lipoprotein lipase.

  Direct binding of apolipoprotein (apo)B-containing lipoproteins to proteoglycans is the initiating event in atherosclerosis, but the processes involve…

  Authors: Maria Gustafsson, Malin Levin, Kristina Skålén, Jeanna Perman, Vincent Fridén, Pernilla Jirholt, Sven-Olof Olofsson, Sergio Fazio, MacRae F Linton, Clay F Semenkovich,…

  Source: Circulation research. 2007 Oct 12

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• Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice.

  BACKGROUND: Cyclooxygenase-1 (COX-1) has been implicated in the pathogenesis of atherothrombosis and is expressed by the major cell types of atheroscl…

  Authors: Vladimir R Babaev, Lei Ding, Jeff Reese, Jason D Morrow, Matthew D Breyer, Sudhansu K Dey, Sergio Fazio, MacRae F Linton

  Source: Circulation. 2006 Jan 3

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• Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1.

  BACKGROUND: Macrophage acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) and apolipoprotein E (apoE) have been implicated in regulating cellular c…

  Authors: Yan Ru Su, Dwayne E Dove, Amy S Major, Alyssa H Hasty, Branden Boone, MacRae F Linton, Sergio Fazio

  Source: Circulation. 2005 May 10

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• Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice.

  BACKGROUND: The adipocyte fatty acid-binding protein (FABP) aP2 is expressed by adipocytes and macrophages and modulates insulin resistance, glucose a…

  Authors: Jeffrey B Boord, Kazuhisa Maeda, Liza Makowski, Vladimir R Babaev, Sergio Fazio, MacRae F Linton, Gökhan S Hotamisligil

  Source: Circulation. 2004 Sep 14

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• Self-association of human PCSK9 correlates with its LDLR-degrading activity.

  Genetic studies have demonstrated an important role for proprotein convertase subtilisin/kexin type 9 (PCSK9) as a determinant of plasma cholesterol l…

  Authors: Daping Fan, Patricia G Yancey, Shenfeng Qiu, Lei Ding, Edwin J Weeber, MacRae F Linton, Sergio Fazio

  Source: Biochemistry. 2008 Feb 12

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