1 to 10 of 81 literature results

• Conjugated linoleic acid prevents cell growth and cytokine production induced by TPA in human keratinocytes NCTC 2544.

  Conjugated linoleic acid (CLA) is reported to have anti-cancer activity, based on animal and in vitro studies. Since it has been suggested that CLA an…

  Authors: Germana Martinasso, Silvia Saracino, Marina Maggiora, Manuela Oraldi, Rosa A Canuto, Giuliana Muzio

  Source: Cancer letters. 2010 Jan 1

  View Full Text

• Molecular diversity: from small to large, emerging to enabling.

  Authors: Christopher Hulme, Gerald M Maggiora

  Source: Current opinion in chemical biology. 2008 Jun

  View Full Text

• Changes in IL-8 release and intracellular content in DMSO-differentiated HL-60 cells after treatment with 4-hydroxynonenal.

  4-Hydroxynonenal (HNE), a chemotactic aldehyde produced by lipid peroxidation, has been shown to trigger exocytosis in HL-60 cells induced to differen…

  Authors: Marina Maggiora, Maria Armida Rossi

  Source: Cell biochemistry and function. 2008 Sep-Oct

  View Full Text

• Hit-directed nearest-neighbor searching.

  This work describes a practical strategy used at Pharmacia for identifying compounds for follow-up screening following an initial HTS campaign against…

  Authors: Veerabahu Shanmugasundaram, Gerald M Maggiora, Michael S Lajiness

  Source: Journal of medicinal chemistry. 2005 Jan 13

  View Full Text

• Synthesis of platinum(II) chiral tetraamine coordination complexes.

  The individual and combinatorial syntheses of individual as well as a mixture-based diversity of 195 112 platinum(II) coordination complexes of chiral…

  Authors: Adel Nefzi, Cornelia E Hoesl, Clemencia Pinilla, George B Kauffman, Gerald M Maggiora, Elena Pasquale, Richard A Houghten

  Source: Journal of combinatorial chemistry. 2006 Sep-Oct

  View Full Text

• Assessment of the consistency of medicinal chemists in reviewing sets of compounds.

  Medicinal chemists are frequently asked to review lists of compounds to assess their drug- or leadlike nature and to evaluate the suitability of lead …

  Authors: Michael S Lajiness, Gerald M Maggiora, Veerabahu Shanmugasundaram

  Source: Journal of medicinal chemistry. 2004 Sep 23

  View Full Text

• The exocytosis induced in HL-60 cells by 4-hydroxynonenal, a lipid peroxidation product, is not prevented by reduced glutathione.

  The effect of reduced glutathione (GSH) was studied on exocytosis triggered by 4-hydroxynonenal in HL-60 cells induced to differentiate towards the gr…

  Authors: Marina Maggiora, Maria Armida Rossi

  Source: Cell biochemistry and function. 2006 Jan-Feb

  View Full Text

• Evaluating molecular similarity using reduced representations of the electron density.

  A model system of four benzodiazepine-like ligands for the central benzodiazepine receptors (CBRs) and peripheral benzodiazepine receptors (PBRs)is ex…

  Authors: Nathalie Meurice, Gerald M Maggiora, Daniel P Vercauteren

  Source: Journal of molecular modeling. 2005 Jun

  View Full Text

• Data shaving: a focused screening approach.

  The number of compounds available for evaluation as part of the drug discovery process continues to increase. These compounds may exist physically or …

  Authors: Suzanne K Schreyer, Christian N Parker, Gerald M Maggiora

  Source: Journal of chemical information and computer sciences. 2004 Mar-Apr

  View Full Text

• Arachidonic and docosahexaenoic acids reduce the growth of A549 human lung-tumor cells increasing lipid peroxidation and PPARs.

  Polyunsaturated fatty acids (PUFAs) play an important role in both induction and prevention of carcinogenic process. It is well known that several typ…

  Authors: Antonella Trombetta, Marina Maggiora, Germana Martinasso, Paolo Cotogni, Rosa A Canuto, Giuliana Muzio

  Source: Chemico-biological interactions. 2007 Feb 20

  View Full Text