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Production of Wnt inhibitors by myeloma cells: potential effects on canonical Wnt pathway in the bone microenvironment.
Osteoblast impairment occurs within multiple myeloma cell infiltration into the bone marrow. Canonical Wnt signaling activation in osteoprogenitor cel…
Authors: Nicola Giuliani, Francesca Morandi, Sara Tagliaferri, Mirca Lazzaretti, Gaetano Donofrio, Sabrina Bonomini, Roberto Sala, Marcellina Mangoni, Vittorio Rizzoli
Source: Cancer research. 2007 Aug 15
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The proteasome inhibitor bortezomib affects osteoblast differentiation in vitro and in vivo in multiple myeloma patients.
The proteasome inhibitor bortezomib may increase osteoblast-related markers in multiple myeloma (MM) patients; however, its potential osteoblastic sti…
Authors: Nicola Giuliani, Francesca Morandi, Sara Tagliaferri, Mirca Lazzaretti, Sabrina Bonomini, Monica Crugnola, Cristina Mancini, Eugenia Martella, Luca Ferrari, Antonio Tabilio,…
Source: Blood. 2007 Jul 1
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CC-Chemokine ligand 20/macrophage inflammatory protein-3alpha and CC-chemokine receptor 6 are overexpressed in myeloma microenvironment related to osteolytic bone lesions.
The expression of the chemokine CC-chemokine ligand 20 (CCL20)/macrophage inflammatory protein (MIP)-3alpha and its receptor CC-chemokine receptor 6 (…
Authors: Nicola Giuliani, Gina Lisignoli, Simona Colla, Mirca Lazzaretti, Paola Storti, Cristina Mancini, Sabrina Bonomini, Cristina Manferdini, Katia Codeluppi, Andrea Facchini,…
Source: Cancer research. 2008 Aug 15
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The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha (HIF-1alpha) activity: involvement in myeloma-induced angiogenesis.
Angiogenesis has a critical role in the pathophysiology of multiple myeloma (MM); however, the molecular mechanisms underlying this process are not co…
Authors: Simona Colla, Sara Tagliaferri, Francesca Morandi, Paolo Lunghi, Gaetano Donofrio, Davide Martorana, Cristina Mancini, Mirca Lazzaretti, Laura Mazzera, Lara Ravanetti,…
Source: Blood. 2007 Dec 15
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Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation.
Decreased bone formation contributes to the development of bone lesions in multiple myeloma (MM) patients. In this study, we have investigated the eff…
Authors: Nicola Giuliani, Simona Colla, Francesca Morandi, Mirca Lazzaretti, Roberto Sala, Sabrina Bonomini, Maria Grano, Silvia Colucci, Mirija Svaldi, Vittorio Rizzoli
Source: Blood. 2005 Oct 1
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Intracranial hematopoiesis in a patient with AIDS-related central nervous system lymphoma and severe pancytopenia.
The case here reported reflects the difficulty in diagnosing meningeal extramedullary hematopoiesis (EMH), which clinically appeared concomitantly wit…
Authors: A Musolino, A Guazzi, M Lazzaretti, D Pezzuolo, C Calzetti, A Degli Antoni, A Ardizzoni
Source: Haematologica. 2007 May
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Cognitive memory control in borderline personality disorder patients.
BACKGROUND: It has been demonstrated that the mechanism of cognitive memory control in humans is sustained by the hippocampus and prefrontal cortices,…
Authors: M Sala, E Caverzasi, E Marraffini, G De Vidovich, M Lazzaretti, G d'Allio, M Isola, M Balestrieri, E D'Angelo, F Zappoli Thyrion,…
Source: Psychological medicine. 2009 May
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Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment.
Although osteolysis is a common complication in patients with multiple myeloma (MM), the biologic mechanisms involved in the pathogenesis of MM-induce…
Authors: N Giuliani, R Bataille, C Mancini, M Lazzaretti, S Barillé
Source: Blood. 2001 Dec 15
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Proangiogenic properties of human myeloma cells: production of angiopoietin-1 and its potential relationship to myeloma-induced angiogenesis.
Patients with multiple myeloma (MM) have increased bone marrow (BM) angiogenesis; however, the proangiogenic properties of myeloma cells and the mecha…
Authors: Nicola Giuliani, Simona Colla, Mirca Lazzaretti, Roberto Sala, Giovanni Roti, Cristina Mancini, Sabrina Bonomini, Paolo Lunghi, Magda Hojden, Giovenzio Genestreti,…
Source: Blood. 2003 Jul 15
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Human myeloma cells stimulate the receptor activator of nuclear factor-kappa B ligand (RANKL) in T lymphocytes: a potential role in multiple myeloma bone disease.
The biologic mechanisms involved in the pathogenesis of multiple myeloma (MM) bone disease are not completely understood. Recent evidence suggests tha…
Authors: Nicola Giuliani, Simona Colla, Roberto Sala, Matteo Moroni, Mirca Lazzaretti, Silvia La Monica, Sabrina Bonomini, Magda Hojden, Gabriella Sammarelli, Sophie Barillè,…
Source: Blood. 2002 Dec 15
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