1 to 10 of 789 literature results

• Caspases and kinases in a death grip.

  The complex process of apoptosis is orchestrated by caspases, a family of cysteine proteases with unique substrate specificities. Accumulating evidenc…

  Authors: Manabu Kurokawa, Sally Kornbluth

  Source: Cell. 2009 Sep 4

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• Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.

  Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to loss of heterozygosity. aUPD is associated not only with loss-of-…

  Authors: Masashi Sanada, Takahiro Suzuki, Lee-Yung Shih, Makoto Otsu, Motohiro Kato, Satoshi Yamazaki, Azusa Tamura, Hiroaki Honda, Mamiko Sakata-Yanagimoto, Keiki Kumano,…

  Source: Nature. 2009 Aug 13

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• Frequent inactivation of A20 in B-cell lymphomas.

  A20 is a negative regulator of the NF-kappaB pathway and was initially identified as being rapidly induced after tumour-necrosis factor-alpha stimulat…

  Authors: Motohiro Kato, Masashi Sanada, Itaru Kato, Yasuharu Sato, Junko Takita, Kengo Takeuchi, Akira Niwa, Yuyan Chen, Kumi Nakazaki, Junko Nomoto,…

  Source: Nature. 2009 Jun 4

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• The role of Runx1/AML1 and Evi-1 in the regulation of hematopoietic stem cells.

  Lineage-specific transcription factors must be precisely regulated during stem cell self-renewal and lineage commitment decisions. The role of specifi…

  Authors: Keiki Kumano, Mineo Kurokawa

  Source: Journal of cellular physiology. 2010 Feb

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• Inhibition of apoptosome formation by suppression of Hsp90beta phosphorylation in tyrosine kinase-induced leukemias.

  Constitutively active tyrosine kinases promote leukemogenesis by increasing cell proliferation and inhibiting apoptosis. However, mechanisms underlyin…

  Authors: Manabu Kurokawa, Chen Zhao, Tannishtha Reya, Sally Kornbluth

  Source: Molecular and cellular biology. 2008 Sep

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• AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis.

  Embryonic development of multilineage hematopoiesis requires the precisely regulated expression of lineage-specific transcription factors, including A…

  Authors: Motoshi Ichikawa, Takashi Asai, Toshiki Saito, Sachiko Seo, Ieharu Yamazaki, Tetsuya Yamagata, Kinuko Mitani, Shigeru Chiba, Seishi Ogawa, Mineo Kurokawa,…

  Source: Nature medicine. 2004 Mar

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• Derivation of functional mature neutrophils from human embryonic stem cells.

  Human embryonic stem cells (hESCs) proliferate infinitely and are pluripotent. Only a few reports, however, describe specific and efficient methods to…

  Authors: Yasuhisa Yokoyama, Takahiro Suzuki, Mamiko Sakata-Yanagimoto, Keiki Kumano, Katsumi Higashi, Tsuyoshi Takato, Mineo Kurokawa, Seishi Ogawa, Shigeru Chiba

  Source: Blood. 2009 Jun 25

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• Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2.

  Xenopus oocyte death is partly controlled by the apoptotic initiator caspase-2 (C2). We reported previously that oocyte nutrient depletion activates C…

  Authors: Leta K Nutt, Marisa R Buchakjian, Eugene Gan, Rashid Darbandi, Sook-Young Yoon, Judy Q Wu, Yuko J Miyamoto, Jennifer A Gibbon, Josh L Andersen, Christopher D Freel,…

  Source: Developmental cell. 2009 Jun

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• Evaluation of genome-wide power of genetic association studies based on empirical data from the HapMap project.

  With recent advances in high-throughput single nucleotide polymorphism (SNP) typing technologies, genome-wide association studies have become a realis…

  Authors: Yasuhito Nannya, Kenjiro Taura, Mineo Kurokawa, Shigeru Chiba, Seishi Ogawa

  Source: Human molecular genetics. 2007 Oct 15

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• Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia.

  Hairy enhancer of split 1 (Hes1) is a basic helix-loop-helix transcriptional repressor that affects differentiation and often helps maintain cells in …

  Authors: Fumio Nakahara, Mamiko Sakata-Yanagimoto, Yukiko Komeno, Naoko Kato, Tomoyuki Uchida, Kyoko Haraguchi, Keiki Kumano, Yuka Harada, Hironori Harada, Jiro Kitaura,…

  Source: Blood. 2009 Oct 27

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