1 to 10 of 43 literature results

• Loss of FOXA1/2 is essential for the epithelial-to-mesenchymal transition in pancreatic cancer.

  FOXA1 and FOXA2, members of the forkhead transcription factor family, are critical for epithelial differentiation in many endoderm-derived organs, inc…

  Authors: Yan Song, M Kay Washington, Howard C Crawford

  Source: Cancer research. 2010 Mar 1

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• Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappaB.

  BACKGROUND & AIMS: Raf-1 kinase is a key regulator of a number of cellular processes, which promote the maintenance of a healthy colon epithelium. Thi…

  Authors: Karen L Edelblum, M Kay Washington, Tatsuki Koyama, Sylvie Robine, Manuela Baccarini, D Brent Polk

  Source: Gastroenterology. 2008 Aug

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• TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway.

  BACKGROUND & AIMS: During colorectal cancer pathogenesis, mutations and epigenetic events cause neoplastic behavior in epithelial cells by deregulatin…

  Authors: Patty Trobridge, Sue Knoblaugh, M Kay Washington, Nina M Munoz, Karen D Tsuchiya, Andres Rojas, Xiaoling Song, Cornelia M Ulrich, Takehiko Sasazuki, Senji Shirasawa,…

  Source: Gastroenterology. 2009 May

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• Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth.

  BACKGROUND & AIMS: Increased inflammatory cytokine levels and intestinal epithelial cell apoptosis leading to disruption of epithelial integrity are m…

  Authors: Fang Yan, Hanwei Cao, Timothy L Cover, Robert Whitehead, M Kay Washington, D Brent Polk

  Source: Gastroenterology. 2007 Feb

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• Transmembrane and soluble isoforms of heparin-binding epidermal growth factor-like growth factor regulate distinct processes in the pancreas.

  BACKGROUND & AIMS: Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is produced as a type-I, single-pass transmembrane protein that…

  Authors: Kevin C Ray, Stacy A Blaine, M Kay Washington, Ada H Braun, Amar B Singh, Raymond C Harris, Paul A Harding, Robert J Coffey, Anna L Means

  Source: Gastroenterology. 2009 Nov

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• Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis.

  BACKGROUND & AIMS: Helicobacter pylori infection disrupts the balance between gastric epithelial cell proliferation and apoptosis, which is likely to …

  Authors: Fang Yan, Hanwei Cao, Rupesh Chaturvedi, Uma Krishna, Stuart S Hobbs, Peter J Dempsey, Richard M Peek, Timothy L Cover, M Kay Washington, Keith T Wilson,…

  Source: Gastroenterology. 2009 Apr

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• Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer.

  BACKGROUND & AIMS: Staging inadequately predicts metastatic risk in patients with colon cancer. We used a gene expression profile derived from invasiv…

  Authors: J Joshua Smith, Natasha G Deane, Fei Wu, Nipun B Merchant, Bing Zhang, Aixiang Jiang, Pengcheng Lu, J Chad Johnson, Carl Schmidt, Christina E Bailey,…

  Source: Gastroenterology. 2010 Mar

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• Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice.

  Helicobacter pylori-induced gastritis is the strongest singular risk factor for gastric adenocarcinoma. Matrix metalloproteinase-7 (MMP-7) is a proteo…

  Authors: Seth R Ogden, Jennifer M Noto, Shannon S Allen, Dilan A Patel, Judith Romero-Gallo, M Kay Washington, Barbara Fingleton, Dawn A Israel, Nuruddeen D Lewis, Keith T Wilson,…

  Source: Cancer research. 2010 Jan 1

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• Overexpression of OATP1B3 confers apoptotic resistance in colon cancer.

  Organic anion transporting polypeptide 1B3 (OATP1B3, SLCO1B3) is normally expressed in hepatocytes. In this study, we showed frequent overexpression o…

  Authors: Wooin Lee, Abbes Belkhiri, A Craig Lockhart, Nipun Merchant, Hartmut Glaeser, Elizabeth I Harris, M Kay Washington, Elizabeth M Brunt, Alex Zaika, Richard B Kim,…

  Source: Cancer research. 2008 Dec 15

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• Deletion of Mtgr1 sensitizes the colonic epithelium to dextran sodium sulfate-induced colitis.

  BACKGROUND & AIMS: The disruption of homeostasis between proliferation and apoptosis in the colonic epithelium contributes to the pathogenesis of huma…

  Authors: J Andres Martinez, Christopher S Williams, Joseph M Amann, Tiffany C Ellis, Isabel Moreno-Miralles, M Kay Washington, Paul Gregoli, Scott W Hiebert

  Source: Gastroenterology. 2006 Aug

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