1 to 10 of 133 literature results

• Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin.

  Huntington's disease is caused by an expanded CAG repeat in the gene encoding huntingtin (HTT), resulting in loss of striatal and cortical neurons. Gi…

  Authors: Shu-ichi Okamoto, Mahmoud A Pouladi, Maria Talantova, Dongdong Yao, Peng Xia, Dagmar E Ehrnhoefer, Rameez Zaidi, Arjay Clemente, Marcus Kaul, Rona K Graham,…

  Source: Nature medicine. 2009 Dec

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• HIV-1 associated dementia: update on pathological mechanisms and therapeutic approaches.

  PURPOSE OF REVIEW: Infection with HIV-1 can induce dementia despite successful administration of life-prolonging highly active antiretroviral therapy.…

  Authors: Marcus Kaul

  Source: Current opinion in neurology. 2009 Jun

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• Pathways to neuronal injury and apoptosis in HIV-associated dementia.

  Human immunodeficiency virus-1 (HIV-1) can induce dementia with alarming occurrence worldwide. The mechanism remains poorly understood, but discovery …

  Authors: M Kaul, G A Garden, S A Lipton

  Source: Nature. 2001 Apr 19

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• HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection.

  The chemokine receptors CCR5 and CXCR4 serve, in addition to CD4, as coreceptors for human immunodeficiency virus-1 (HIV-1), and infection with HIV-1 …

  Authors: M Kaul, Q Ma, K E Medders, M K Desai, S A Lipton

  Source: Cell death and differentiation. 2007 Feb

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• Molecular stages of rapid and uniform neuralization of human embryonic stem cells.

  Insights into early human development are fundamental for our understanding of human biology. Efficient differentiation of human embryonic stem cells …

  Authors: R Bajpai, G Coppola, M Kaul, M Talantova, F Cimadamore, M Nilbratt, D H Geschwind, S A Lipton, A V Terskikh

  Source: Cell death and differentiation. 2009 Jun

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• Aminoglycoside-induced reduction in nucleotide mobility at the ribosomal RNA A-site as a potentially key determinant of antibacterial activity.

  Steady-state and time-resolved fluorescence techniques have been used to characterize the energetics and dynamics associated with the interaction of a…

  Authors: Malvika Kaul, Christopher M Barbieri, Daniel S Pilch

  Source: Journal of the American Chemical Society. 2006 Feb 1

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• Molecular determinants of antibiotic recognition and resistance by aminoglycoside phosphotransferase (3')-IIIa: a calorimetric and mutational analysis.

  The growing threat from the emergence of multidrug resistant pathogens highlights a critical need to expand our currently available arsenal of broad-s…

  Authors: Malvika Kaul, Christopher M Barbieri, Annankoil R Srinivasan, Daniel S Pilch

  Source: Journal of molecular biology. 2007 May 25

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• HIV-1 infection and AIDS: consequences for the central nervous system.

  Infection with the human immunodeficiency virus-1 (HIV-1) can induce severe and debilitating neurological problems that include behavioral abnormaliti…

  Authors: M Kaul, J Zheng, S Okamoto, H E Gendelman, S A Lipton

  Source: Cell death and differentiation. 2005 Aug

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• Assessment of the 2006 revised antiphospholipid syndrome classification criteria.

  OBJECTIVE: To analyse antiphospholipid (aPL) antibody-positive patients using the 2006 revised antiphospholipid syndrome (APS) classification criteria…

  Authors: Mala Kaul, Doruk Erkan, Lisa Sammaritano, Michael D Lockshin

  Source: Annals of the rheumatic diseases. 2007 Jul

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• Defining the basis for the specificity of aminoglycoside-rRNA recognition: a comparative study of drug binding to the A sites of Escherichia coli and human rRNA.

  2-Deoxystreptamine (2-DOS) aminoglycoside antibiotics exert their antimicrobial activities by targeting the decoding region A site of the rRNA and inh…

  Authors: Malvika Kaul, Christopher M Barbieri, Daniel S Pilch

  Source: Journal of molecular biology. 2005 Feb 11

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