1 to 10 of 14 literature results

• Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation.

  T-cell activation requires clustering of a threshold number of T-cell receptors (TCRs) at the site of antigen presentation, a number that is reduced b…

  Authors: M Demetriou, M Granovsky, S Quaggin, J W Dennis

  Source: Nature. 2001 Feb 8

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• Suppression of tumor growth and metastasis in Mgat5-deficient mice.

  Golgi beta1,6N-acetylglucosaminyltransferase V (MGAT5) is required in the biosynthesis of beta1,6GlcNAc-branched N-linked glycans attached to cell sur…

  Authors: M Granovsky, J Fata, J Pawling, W J Muller, R Khokha, J W Dennis

  Source: Nature medicine. 2000 Mar

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• Genetic defects in N-glycosylation and cellular diversity in mammals.

  Glycoproteins in mammalian cells are modified with complex-type aspargine-linked glycans of variable chain lengths and composition. Observations of mi…

  Authors: J W Dennis, C E Warren, M Granovsky, M Demetriou

  Source: Current opinion in structural biology. 2001 Oct

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• Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis.

  The Golgi enzyme beta1,6 N-acetylglucosaminyltransferase V (Mgat5) is up-regulated in carcinomas and promotes the substitution of N-glycan with poly N…

  Authors: Emily A Partridge, Christine Le Roy, Gianni M Di Guglielmo, Judy Pawling, Pam Cheung, Maria Granovsky, Ivan R Nabi, Jeffrey L Wrana, James W Dennis

  Source: Science (New York, N.Y.). 2004 Oct 1

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• Investigation of leukemia cells from children with common acute lymphoblastic leukemia for genomic sequences of the primate polyomaviruses JC virus, BK virus, and simian virus 40.

  BACKGROUND: An infectious etiology for childhood acute lymphoblastic leukemia (ALL) has long been suspected, although the characteristics of the putat…

  Authors: M A Smith, H D Strickler, M Granovsky, G Reaman, M Linet, R Daniel, K V Shah

  Source: Medical and pediatric oncology. 1999 Nov

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• Complex asparagine-linked oligosaccharides in Mgat1-null embryos.

  To investigate the developmental role of complex N-linked oligosaccharides, we previously inactivated the mouse Mgat1 gene which encodes UDP-N-acetylg…

  Authors: R M Campbell, M Metzler, M Granovsky, J W Dennis, J D Marth

  Source: Glycobiology. 1995 Jul

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• Protein glycosylation in development and disease.

  N- and O-linked glycan structures of cell surface and secreted glycoproteins serve a variety of functions related to cell-cell communication in system…

  Authors: J W Dennis, M Granovsky, C E Warren

  Source: BioEssays : news and reviews in molecular, cellular and developmental biology. 1999 May

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• GlcNAc-transferase V and core 2 GlcNAc-transferase expression in the developing mouse embryo.

  UDP-GlcNAc:Manalpha1-6Manbeta-R beta1-6-N-acetylglucosaminyltransferase V (GlcNAc-TV) and UDP-GlcNAc:Galbeta1-3GalNAc-R beta1-6-N-acetylglucosaminyltr…

  Authors: M Granovsky, C Fode, C E Warren, R M Campbell, J D Marth, M Pierce, N Fregien, J W Dennis

  Source: Glycobiology. 1995 Dec

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• Glycoprotein glycosylation and cancer progression.

  Glycosylation of glycoproteins and glycolipids is one of many molecular changes that accompany malignant transformation. GlcNAc-branched N-glycans and…

  Authors: J W Dennis, M Granovsky, C E Warren

  Source: Biochimica et biophysica acta. 1999 Dec 6

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• Antisense and sense cDNA expression cloning using autonomously replicating vectors and toxic lectin selection.

  CHOP2 cells, a subline of the Chinese hamster ovary (CHO) cell glycosylation mutant Lec2 which expresses polyoma virus large T antigen, was used as th…

  Authors: L Cummings, C E Warren, M Granovsky, J W Dennis

  Source: Biochemical and biophysical research communications. 1993 Sep 15

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