1 to 10 of 3,365 literature results

• Induction of hepatitis by JNK-mediated expression of TNF-alpha.

  The c-Jun NH(2)-terminal kinase (JNK) signaling pathway has been implicated in the development of tumor necrosis factor (TNF)-dependent hepatitis. JNK…

  Authors: Madhumita Das, Guadalupe Sabio, Feng Jiang, Mercedes Rincón, Richard A Flavell, Roger J Davis

  Source: Cell. 2009 Jan 23

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• In situ carcinoma - can we predict which patient will come back with a recurrence?

  The frequency of in situ carcinomas has been rising since the introduction of mammographic screening. The management of patients with preinvasive dise…

  Authors: Peter T Simpson, Leonard M Da Silva, Sunil R Lakhani

  Source: Cancer cell. 2007 Nov

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• A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia.

  We report the first identified mutation in the gene encoding human cytochrome c (CYCS). Glycine 41, invariant throughout eukaryotes, is substituted by…

  Authors: Ian M Morison, Elisabeth M Cramer Bordé, Emma J Cheesman, Pak Leng Cheong, Andrew J Holyoake, Serge Fichelson, Robert J Weeks, Alexandra Lo, Stefan M K Davies, Sigurd M Wilbanks,…

  Source: Nature genetics. 2008 Apr

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• Robo2-Slit1 dependent cell-cell interactions mediate assembly of the trigeminal ganglion.

  Vertebrate cranial sensory ganglia, responsible for sensation of touch, taste and pain in the face and viscera, are composed of both ectodermal placod…

  Authors: Celia E Shiau, Peter Y Lwigale, Raman M Das, Stuart A Wilson, Marianne Bronner-Fraser

  Source: Nature neuroscience. 2008 Mar

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• Chemokine signaling via the CXCR2 receptor reinforces senescence.

  Cells enter senescence, a state of stable proliferative arrest, in response to a variety of cellular stresses, including telomere erosion, DNA damage,…

  Authors: Juan C Acosta, Ana O'Loghlen, Ana Banito, Maria V Guijarro, Arnaud Augert, Selina Raguz, Marzia Fumagalli, Marco Da Costa, Celia Brown, Nikolay Popov,…

  Source: Cell. 2008 Jun 13

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• Spinal cord stimulation improves ventricular function and reduces ventricular arrhythmias in a canine postinfarction heart failure model.

  BACKGROUND: Spinal cord stimulation (SCS) reduces the incidence of ventricular tachyarrhythmias in experimental models. This study investigated the ef…

  Authors: John C Lopshire, Xiaohong Zhou, Cristian Dusa, Takeshi Ueyama, Joshua Rosenberger, Nicole Courtney, Michael Ujhelyi, Thomas Mullen, Mithilesh Das, Douglas P Zipes

  Source: Circulation. 2009 Jul 28

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• Inhibition of mitochondrial permeability transition pore opening by ischemic preconditioning is probably mediated by reduction of oxidative stress rather than mitochondrial protein phosphorylation.

  Inhibition of mitochondrial permeability transition pore (MPTP) opening at reperfusion is critical for cardioprotection by ischemic preconditioning (I…

  Authors: Samantha J Clarke, Igor Khaliulin, Manika Das, Joanne E Parker, Kate J Heesom, Andrew P Halestrap

  Source: Circulation research. 2008 May 9

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• Copper-catalyzed domino intra- and intermolecular C-S cross-coupling reactions: synthesis of 2-(arylthio)arylcyanamides.

  One-pot synthesis of 2-(arylthio)arylcyanamides is accomplished using cheap and air-stable CuSO(4) x 5 H(2)O as a catalyst by domino intra- and interm…

  Authors: Tamminana Ramana, Prasenjit Saha, Manas Das, Tharmalingam Punniyamurthy

  Source: Organic letters. 2010 Jan 1

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• Generation of survival signal by differential interaction of p38MAPKalpha and p38MAPKbeta with caveolin-1 and caveolin-3 in the adapted heart.

  Sphingomyelin breakdown product ceramide has recently been found to induce an adaptive response and reduce myocardial ischemia/reperfusion injury. Sin…

  Authors: Manika Das, Jianhua Cui, Dipak K Das

  Source: Journal of molecular and cellular cardiology. 2007 Jan

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• Mesalamine suppresses the expression of TC22, a novel tropomyosin isoform associated with colonic neoplasia.

  Although a protective role for mesalamine against colon cancer in ulcerative colitis has been shown epidemiologically, its molecular mechanism is unkn…

  Authors: Koushik K Das, Manisha Bajpai, Yingxin Kong, Jianying Liu, Xin Geng, Kiron M Das

  Source: Molecular pharmacology. 2009 Jul

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