1 to 10 of 12 literature results

• Identification of loci associated with schizophrenia by genome-wide association and follow-up.

  We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional…

  Authors: Michael C O'Donovan, Nicholas Craddock, Nadine Norton, Hywel Williams, Timothy Peirce, Valentina Moskvina, Ivan Nikolov, Marian Hamshere, Liam Carroll, Lyudmila Georgieva,…

  Source: Nature genetics. 2008 Sep

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• Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia.

  Copy number variations (CNVs) account for a substantial proportion of human genomic variation, and have been shown to cause neurodevelopmental disorde…

  Authors: George Kirov, Dilihan Gumus, Wei Chen, Nadine Norton, Lyudmila Georgieva, Murat Sari, Michael C O'Donovan, Fikret Erdogan, Michael J Owen, Hans-Hilger Ropers,…

  Source: Human molecular genetics. 2008 Feb 1

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• Support for neuregulin 1 as a susceptibility gene for bipolar disorder and schizophrenia.

  BACKGROUND: There is support that Neuregulin 1 (NRG1) plays a role in susceptibility to schizophrenia but limited evidence for its involvement in bipo…

  Authors: Lyudmila Georgieva, Albena Dimitrova, Dobril Ivanov, Ivan Nikolov, Nigel M Williams, Detelina Grozeva, Irina Zaharieva, Draga Toncheva, Michael J Owen, George Kirov,…

  Source: Biological psychiatry. 2008 Sep 1

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• A network of dopaminergic gene variations implicated as risk factors for schizophrenia.

  We evaluated the hypothesis that dopaminergic polymorphisms are risk factors for schizophrenia (SZ). In stage I, we screened 18 dopamine-related genes…

  Authors: Michael E Talkowski, George Kirov, Mikhil Bamne, Lyudmila Georgieva, Gonzalo Torres, Hader Mansour, Kodavali V Chowdari, Vihra Milanova, Joel Wood, Lora McClain,…

  Source: Human molecular genetics. 2008 Mar 1

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• Variation in the protocadherin gamma A gene cluster.

  We screened for variation in the 12 protocadherin gamma A (PCDHGA) genes of the protocadherin cluster on chromosome 5q31. We used denaturing high-perf…

  Authors: George Kirov, Lyudmila Georgieva, Nigel Williams, Ivan Nikolov, Nadine Norton, Draga Toncheva, Michael O'Donovan, Michael J Owen

  Source: Genomics. 2003 Oct

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• Genetic variation in the seven-pass transmembrane cadherin CELSR1: lack of association with schizophrenia.

  OBJECTIVES: Cadherins play a critical role in morphogenesis and maintenance of neuronal connections in the adult brain. We examined the gene encoding …

  Authors: Lyudmila Georgieva, Ivan Nikolov, Nadezhda Poriazova, Gaynor Jones, Draga Toncheva, George Kirov, Michael J Owen

  Source: Psychiatric genetics. 2003 Jun

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• Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping.

  BACKGROUND: Several linkage studies suggest that chromosome 5q31-32 might contain risk loci for schizophrenia (SZ). We wanted to identify susceptibili…

  Authors: Irina Zaharieva, Lyudmila Georgieva, Ivan Nikolov, George Kirov, Michael J Owen, Michael C O'Donovan, Draga Toncheva

  Source: BMC psychiatry. 2008

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• Major psychiatric disorders and the serotonin transporter gene (SLC6A4): family-based association studies.

  The serotonin transporter (5-HTT) is a suitable candidate gene to test for involvement in the pathogenesis of major psychiatric disorders. We used the…

  Authors: Albena Dimitrova, Lyudmila Georgieva, Ivan Nikolov, Nadejda Poriazova, Stefan Krastev, Draga Toncheva, Michael J Owen, George Kirov

  Source: Psychiatric genetics. 2002 Sep

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• A genome-wide association study for late-onset Alzheimer's disease using DNA pooling.

  BACKGROUND: Late-onset Alzheimer's disease (LOAD) is an age related neurodegenerative disease with a high prevalence that places major demands on heal…

  Authors: Richard Abraham, Valentina Moskvina, Rebecca Sims, Paul Hollingworth, Angharad Morgan, Lyudmila Georgieva, Kimberley Dowzell, Sven Cichon, Axel M Hillmer, Michael C O'Donovan,…

  Source: BMC medical genomics. 2008

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• Pooled DNA genotyping on Affymetrix SNP genotyping arrays.

  BACKGROUND: Genotyping technology has advanced such that genome-wide association studies of complex diseases based upon dense marker maps are now tech…

  Authors: George Kirov, Ivan Nikolov, Lyudmila Georgieva, Valentina Moskvina, Michael J Owen, Michael C O'Donovan

  Source: BMC genomics. 2006

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