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1 to 9 of 9 literature results
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Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice.
The muscular dystrophies are a heterogeneous group of disorders for which there are currently no cures. Oculopharyngeal muscular dystrophy (OPMD) is a…
Authors: Janet E Davies, Lin Wang, Lourdes Garcia-Oroz, Lynnette J Cook, Coralie Vacher, Dominic G O'Donovan, David C Rubinsztein
Source: Nature medicine. 2005 Jun
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The effect of polymorphism at the serotonin transporter gene on decision-making, memory and executive function in ecstasy users and controls.
RATIONALE: 3, 4-Methylenedioxymethamphetamine (MDMA or "ecstasy") is a popular drug of abuse known to result in depletions of the serotonin (5-HT) sys…
Authors: Jonathan P Roiser, Robert D Rogers, Lynnette J Cook, Barbara J Sahakian
Source: Psychopharmacology. 2006 Oct
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Candidate gene association studies of the alpha 4 (CHRNA4) and beta 2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease.
Consistent deficits in the cholinergic system are evident in Alzheimer's disease (AD) patients, including selective loss of alpha4beta2 nicotinic acet…
Authors: Lynnette J Cook, Luk W Ho, Alison E Taylor, Carol Brayne, John Grimley Evans, John Xuereb, Nigel J Cairns, Antonia Pritchard, Helen Lemmon, David Mann,…
Source: Neuroscience letters. 2004 Mar 25
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Association of a functional polymorphism in the serotonin transporter gene with abnormal emotional processing in ecstasy users.
OBJECTIVE: The long-term effects of the use of 3,4-methylenedioxymethamphetamine (MDMA, or Ecstasy) in humans are controversial and unclear. The autho…
Authors: Jonathan P Roiser, Lynnette J Cook, Jason D Cooper, David C Rubinsztein, Barbara J Sahakian
Source: The American journal of psychiatry. 2005 Mar
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Lithium induces autophagy by inhibiting inositol monophosphatase.
Macroautophagy is a key pathway for the clearance of aggregate-prone cytosolic proteins. Currently, the only suitable pharmacologic strategy for up-re…
Authors: Sovan Sarkar, R Andres Floto, Zdenek Berger, Sara Imarisio, Axelle Cordenier, Matthieu Pasco, Lynnette J Cook, David C Rubinsztein
Source: The Journal of cell biology. 2005 Sep 26
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Decreased cAMP response element-mediated transcription: an early event in exon 1 and full-length cell models of Huntington's disease that contributes to polyglutamine pathogenesis.
Huntington's disease (HD) is one of nine neurodegenerative diseases caused by an expanded polyglutamine (polyQ) tract within the disease protein. To c…
Authors: Katharine L Sugars, Rosemary Brown, Lynnette J Cook, Jina Swartz, David C Rubinsztein
Source: The Journal of biological chemistry. 2004 Feb 6
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Mammalian, yeast, bacterial, and chemical chaperones reduce aggregate formation and death in a cell model of oculopharyngeal muscular dystrophy.
Autosomal dominant oculopharyngeal muscular dystrophy (OPMD) is characterized pathologically by intranuclear inclusions in skeletal muscles and is cau…
Authors: Yi Ping Bao, Lynnette J Cook, Dominic O'Donovan, Eiichiro Uyama, David C Rubinsztein
Source: The Journal of biological chemistry. 2002 Apr 5
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Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study.
Consistent deficits in the cholinergic system are evident in the brains of Alzheimer's Disease (AD) patients, including reductions in the activities o…
Authors: Lynnette J Cook, Luk W Ho, Lin Wang, Edith Terrenoire, Carol Brayne, John Grimley Evans, John Xuereb, Nigel J Cairns, Dragana Turic, Paul Hollingworth,…
Source: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2005 Jan 5
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Fragmin60 encodes an actin-binding protein with a C2 domain and controls actin Thr-203 phosphorylation in Physarum plasmodia and sclerotia.
We report the isolation of a cDNA clone encoding a 60-kDa protein termed fragmin60 that cross-reacts with fragmin antibodies. Unlike other gelsolin-re…
Authors: Tatyana Sklyarova, Veerle De Corte, Kris Meerschaert, Liesbeth Devriendt, Berlinda Vanloo, Juliet Bailey, Lynnette J Cook, Mark Goethals, Jozef Van Damme, Magda Puype,…
Source: The Journal of biological chemistry. 2002 Oct 18
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