10 literature results

• The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.

  The proinflammatory cytokine tumor necrosis factor (TNF) alpha signals both cell survival and death. The biological outcome of TNFalpha treatment is d…

  Authors: Lufen Chang, Hideaki Kamata, Giovanni Solinas, Jun-Li Luo, Shin Maeda, K Venuprasad, Yun-Cai Liu, Michael Karin

  Source: Cell. 2006 Feb 10

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• Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases.

  TNFalpha is a pleiotropic cytokine that induces either cell proliferation or cell death. Inhibition of NF-kappaB activation increases susceptibility t…

  Authors: Hideaki Kamata, Shi-Ichi Honda, Shin Maeda, Lufen Chang, Hajime Hirata, Michael Karin

  Source: Cell. 2005 Mar 11

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• A central role for JNK in obesity and insulin resistance.

  Obesity is closely associated with insulin resistance and establishes the leading risk factor for type 2 diabetes mellitus, yet the molecular mechanis…

  Authors: Jiro Hirosumi, Gürol Tuncman, Lufen Chang, Cem Z Görgün, K Teoman Uysal, Kazuhisa Maeda, Michael Karin, Gökhan S Hotamisligil

  Source: Nature. 2002 Nov 21

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• IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha.

  IkappaB kinase beta (IKKbeta) is required for NF-kappaB activation and suppression of TNFalpha-mediated liver apoptosis. To investigate how IKKbeta su…

  Authors: Shin Maeda, Lufen Chang, Zhi-Wei Li, Jun-Li Luo, Hyam Leffert, Michael Karin

  Source: Immunity. 2003 Nov

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• JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins.

  Microtubules (MTs) play an important role in elaboration and maintenance of axonal and dendritic processes. MT dynamics are modulated by MT-associated…

  Authors: Lufen Chang, Ying Jones, Mark H Ellisman, Lawrence S B Goldstein, Michael Karin

  Source: Developmental cell. 2003 Apr

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• Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death.

  Oxidative stress and reactive oxygen species (ROS) can elicit and modulate various physiological and pathological processes, including cell death. How…

  Authors: Han-Ming Shen, Yong Lin, Swati Choksi, Jamie Tran, Tian Jin, Lufen Chang, Michael Karin, Jianke Zhang, Zheng-gang Liu

  Source: Molecular and cellular biology. 2004 Jul

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• Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis.

  OBJECTIVE: Previous studies have demonstrated that inhibition of c-Jun N-terminal kinase (JNK) decreases joint destruction in the rat adjuvant arthrit…

  Authors: Zuoning Han, Lufen Chang, Yuji Yamanishi, Michael Karin, Gary S Firestein

  Source: Arthritis and rheumatism. 2002 Mar

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• Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation.

  A major link between inflammation and cancer is provided by NF-kappaB transcription factors. Ikkbeta(Deltahep) mice, which specifically lack IkappaB k…

  Authors: Toshiharu Sakurai, Shin Maeda, Lufen Chang, Michael Karin

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2006 Jul 11

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• ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage.

  Ribonucleotide reductase small subunit p53R2 was identified as a p53 target gene that provides dNTP for DNA damage repair. However, the slow transcrip…

  Authors: Lufen Chang, Bingsen Zhou, Shuya Hu, Robin Guo, Xiyong Liu, Stephen N Jones, Yun Yen

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2008 Nov 25

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• Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance.

  The c-Jun N-terminal kinases (JNKs) are key regulators of inflammation and interfere with insulin action in cultured cells and whole animals. Obesity …

  Authors: Gürol Tuncman, Jiro Hirosumi, Giovanni Solinas, Lufen Chang, Michael Karin, Gökhan S Hotamisligil

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2006 Jul 11

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