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10 literature results
The proinflammatory cytokine tumor necrosis factor (TNF) alpha signals both cell survival and death. The biological outcome of TNFalpha treatment is d…
Authors: Lufen Chang, Hideaki Kamata, Giovanni Solinas, Jun-Li Luo, Shin Maeda, K Venuprasad, Yun-Cai Liu, Michael Karin
Source: Cell. 2006 Feb 10
View Full TextTNFalpha is a pleiotropic cytokine that induces either cell proliferation or cell death. Inhibition of NF-kappaB activation increases susceptibility t…
Authors: Hideaki Kamata, Shi-Ichi Honda, Shin Maeda, Lufen Chang, Hajime Hirata, Michael Karin
Source: Cell. 2005 Mar 11
View Full TextObesity is closely associated with insulin resistance and establishes the leading risk factor for type 2 diabetes mellitus, yet the molecular mechanis…
Authors: Jiro Hirosumi, Gürol Tuncman, Lufen Chang, Cem Z Görgün, K Teoman Uysal, Kazuhisa Maeda, Michael Karin, Gökhan S Hotamisligil
Source: Nature. 2002 Nov 21
View Full TextIkappaB kinase beta (IKKbeta) is required for NF-kappaB activation and suppression of TNFalpha-mediated liver apoptosis. To investigate how IKKbeta su…
Authors: Shin Maeda, Lufen Chang, Zhi-Wei Li, Jun-Li Luo, Hyam Leffert, Michael Karin
Source: Immunity. 2003 Nov
View Full TextMicrotubules (MTs) play an important role in elaboration and maintenance of axonal and dendritic processes. MT dynamics are modulated by MT-associated…
Authors: Lufen Chang, Ying Jones, Mark H Ellisman, Lawrence S B Goldstein, Michael Karin
Source: Developmental cell. 2003 Apr
View Full TextOxidative stress and reactive oxygen species (ROS) can elicit and modulate various physiological and pathological processes, including cell death. How…
Authors: Han-Ming Shen, Yong Lin, Swati Choksi, Jamie Tran, Tian Jin, Lufen Chang, Michael Karin, Jianke Zhang, Zheng-gang Liu
Source: Molecular and cellular biology. 2004 Jul
View Free Full TextOBJECTIVE: Previous studies have demonstrated that inhibition of c-Jun N-terminal kinase (JNK) decreases joint destruction in the rat adjuvant arthrit…
Authors: Zuoning Han, Lufen Chang, Yuji Yamanishi, Michael Karin, Gary S Firestein
Source: Arthritis and rheumatism. 2002 Mar
View Full TextA major link between inflammation and cancer is provided by NF-kappaB transcription factors. Ikkbeta(Deltahep) mice, which specifically lack IkappaB k…
Authors: Toshiharu Sakurai, Shin Maeda, Lufen Chang, Michael Karin
Source: Proceedings of the National Academy of Sciences of the United States of America. 2006 Jul 11
View Free Full TextRibonucleotide reductase small subunit p53R2 was identified as a p53 target gene that provides dNTP for DNA damage repair. However, the slow transcrip…
Authors: Lufen Chang, Bingsen Zhou, Shuya Hu, Robin Guo, Xiyong Liu, Stephen N Jones, Yun Yen
Source: Proceedings of the National Academy of Sciences of the United States of America. 2008 Nov 25
View Free Full TextThe c-Jun N-terminal kinases (JNKs) are key regulators of inflammation and interfere with insulin action in cultured cells and whole animals. Obesity …
Authors: Gürol Tuncman, Jiro Hirosumi, Giovanni Solinas, Lufen Chang, Michael Karin, Gökhan S Hotamisligil
Source: Proceedings of the National Academy of Sciences of the United States of America. 2006 Jul 11
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