1 to 5 of 5 literature results

• Combination of anastrozole with fulvestrant in the intratumoral aromatase xenograft model.

  Although the aromatase inhibitor anastrozole has been shown to be very effective in the treatment of hormone-dependent postmenopausal breast cancer, s…

  Authors: Luciana F Macedo, Gauri J Sabnis, Olga G Goloubeva, Angela Brodie

  Source: Cancer research. 2008 May 1

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• Stopping treatment can reverse acquired resistance to letrozole.

  Using the intratumoral aromatase xenograft model, we have observed that despite long-lasting growth inhibition, tumors eventually begin to grow during…

  Authors: Gauri J Sabnis, Luciana F Macedo, Olga Goloubeva, Adam Schayowitz, Angela M H Brodie

  Source: Cancer research. 2008 Jun 15

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• Preclinical modeling of endocrine response and resistance: focus on aromatase inhibitors.

  The authors developed a breast cancer intratumoral aromatase model system to compare the antitumor efficacy of several aromatase inhibitors (AIs) and …

  Authors: Luciana F Macedo, Gauri Sabnis, Angela Brodie

  Source: Cancer. 2008 Feb 1

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• Role of androgens on MCF-7 breast cancer cell growth and on the inhibitory effect of letrozole.

  Previous work has shown that androgens inhibit breast cancer cells and tumor growth. On the other hand, androgens can be converted to mitogenic estrog…

  Authors: Luciana F Macedo, Zhiyong Guo, Syreeta L Tilghman, Gauri J Sabnis, Yun Qiu, Angela Brodie

  Source: Cancer research. 2006 Aug 1

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• Synthesis and preliminary pharmacological evaluation of new (+/-) 1,4-naphthoquinones structurally related to lapachol.

  Seven new 1,4-naphthoquinones structurally related to lapachol were synthesized from lawsone and oxygenated arylmercurials. These compounds can also b…

  Authors: Alcides J M da Silva, Camilla D Buarque, Flávia V Brito, Laure Aurelian, Luciana F Macedo, Linda H Malkas, Robert J Hickey, Daniele V S Lopes, François Noël, Yugo L B Murakami,…

  Source: Bioorganic & medicinal chemistry. 2002 Aug

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