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Human leukocyte elastase (HLE) is a serine protease stored in and secreted from neutrophils that plays a determinant role in the pathogenesis of sever…
Authors: Jalmira Mulchande, Rudi Oliveira, Marta Carrasco, Luís Gouveia, Rita C Guedes, Jim Iley, Rui Moreira
Source: Journal of medicinal chemistry. 2010 Jan 14
View Full TextA series of water-soluble dipeptide ester prodrugs of the antiviral acyclovir (ACV) were evaluated for their chemical stability, cytotoxicity, and ant…
Authors: Cledir R Santos, Rita Capela, Cláudia S G P Pereira, Emília Valente, Luís Gouveia, Christophe Pannecouque, Erik De Clercq, Rui Moreira, Paula Gomes
Source: European journal of medicinal chemistry. 2009 Jun
View Full Text5'-O-Dipeptide ester prodrugs of antiviral zidovudine (AZT) were designed to target the human intestinal oligopeptide transporter, hPEPT1, and were ev…
Authors: Cledir Santos, José Morais, Luís Gouveia, Erik de Clercq, Christophe Pannecouque, Carsten Uhd Nielsen, Bente Steffansen, Rui Moreira, Paula Gomes
Source: ChemMedChem. 2008 Jun
View Full TextIn what concerns women and children infected with HIV, clinical investigation related ethical issues are both unavoidable and controversial. Different…
Authors: Luís Gouveia-Andrade
Source: Acta médica portuguesa. 2003 Nov-Dec
View Full TextIn previous attempts to identify dynamical systems properties in patterns of play in team sports, only 2-D analysis methods have been used, implying t…
Authors: Pedro Passos, Duarte Araaújo, Keith Davids, Luís Gouveia, Sidónio Serpa
Source: Behavior research methods. 2006 Nov
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