1 to 5 of 5 literature results

• 4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.

  Human leukocyte elastase (HLE) is a serine protease stored in and secreted from neutrophils that plays a determinant role in the pathogenesis of sever…

  Authors: Jalmira Mulchande, Rudi Oliveira, Marta Carrasco, Luís Gouveia, Rita C Guedes, Jim Iley, Rui Moreira

  Source: Journal of medicinal chemistry. 2010 Jan 14

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• Structure-activity relationships for dipeptide prodrugs of acyclovir: implications for prodrug design.

  A series of water-soluble dipeptide ester prodrugs of the antiviral acyclovir (ACV) were evaluated for their chemical stability, cytotoxicity, and ant…

  Authors: Cledir R Santos, Rita Capela, Cláudia S G P Pereira, Emília Valente, Luís Gouveia, Christophe Pannecouque, Erik De Clercq, Rui Moreira, Paula Gomes

  Source: European journal of medicinal chemistry. 2009 Jun

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• Dipeptide derivatives of AZT: synthesis, chemical stability, activation in human plasma, hPEPT1 affinity, and antiviral activity.

  5'-O-Dipeptide ester prodrugs of antiviral zidovudine (AZT) were designed to target the human intestinal oligopeptide transporter, hPEPT1, and were ev…

  Authors: Cledir Santos, José Morais, Luís Gouveia, Erik de Clercq, Christophe Pannecouque, Carsten Uhd Nielsen, Bente Steffansen, Rui Moreira, Paula Gomes

  Source: ChemMedChem. 2008 Jun

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• Pregnancy, children, clinical trials and HIV infection. Ethical limitations and therapeutical implications

  In what concerns women and children infected with HIV, clinical investigation related ethical issues are both unavoidable and controversial. Different…

  Authors: Luís Gouveia-Andrade

  Source: Acta médica portuguesa. 2003 Nov-Dec

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• Interpersonal dynamics in sport: the role of artificial neural networks and 3-D analysis.

  In previous attempts to identify dynamical systems properties in patterns of play in team sports, only 2-D analysis methods have been used, implying t…

  Authors: Pedro Passos, Duarte Araaújo, Keith Davids, Luís Gouveia, Sidónio Serpa

  Source: Behavior research methods. 2006 Nov

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