1 to 3 of 3 literature results

• Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice.

  The muscular dystrophies are a heterogeneous group of disorders for which there are currently no cures. Oculopharyngeal muscular dystrophy (OPMD) is a…

  Authors: Janet E Davies, Lin Wang, Lourdes Garcia-Oroz, Lynnette J Cook, Coralie Vacher, Dominic G O'Donovan, David C Rubinsztein

  Source: Nature medicine. 2005 Jun

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• Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease.

  Huntington's disease is a devastating neurodegenerative condition associated with the formation of intraneuronal aggregates by mutant huntingtin. Aggr…

  Authors: Coralie Vacher, Lourdes Garcia-Oroz, David C Rubinsztein

  Source: Human molecular genetics. 2005 Nov 15

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• Rapamycin alleviates toxicity of different aggregate-prone proteins.

  Many neurodegenerative diseases are caused by intracellular, aggregate-prone proteins, including polyglutamine-expanded huntingtin in Huntington's dis…

  Authors: Zdenek Berger, Brinda Ravikumar, Fiona M Menzies, Lourdes Garcia Oroz, Benjamin R Underwood, Menelas N Pangalos, Ina Schmitt, Ullrich Wullner, Bernd O Evert, Cahir J O'Kane,…

  Source: Human molecular genetics. 2006 Feb 1

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