1 to 8 of 8 literature results

• Genomic copy number variation, human health, and disease.

  Despite the long recognised effects of chromosomal structural abnormalities and completion of the Human Genome Project, much of the structural variati…

  Authors: Louise V Wain, John A L Armour, Martin D Tobin

  Source: Lancet. 2009 Jul 25

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• Genome-wide association study identifies five loci associated with lung function.

  Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We test…

  Authors: Emmanouela Repapi, Ian Sayers, Louise V Wain, Paul R Burton, Toby Johnson, Ma'en Obeidat, Jing Hua Zhao, Adaikalavan Ramasamy, Guangju Zhai, Veronique Vitart,…

  Source: Nature genetics. 2010 Jan

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• Genome-wide association study identifies eight loci associated with blood pressure.

  Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influenci…

  Authors: Christopher Newton-Cheh, Toby Johnson, Vesela Gateva, Martin D Tobin, Murielle Bochud, Lachlan Coin, Samer S Najjar, Jing Hua Zhao, Simon C Heath, Susana Eyheramendy,…

  Source: Nature genetics. 2009 May 10

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• Common variation in the WNK1 gene and blood pressure in childhood: the Avon Longitudinal Study of Parents and Children.

  WNK1 gene variants have been associated with adult blood pressure. We aimed to investigate relationships between WNK1 variants and blood pressure, as …

  Authors: Martin D Tobin, Nicholas J Timpson, Louise V Wain, Susan Ring, Louise R Jones, Pauline M Emmett, Thomas M Palmer, Andrew R Ness, Nilesh J Samani, George Davey Smith,…

  Source: Hypertension. 2008 Nov

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• Adaptation of HIV-1 to its human host.

  Human immunodeficiency virus type 1 (HIV-1) originated from three independent cross-species transmissions of simian immunodeficiency virus (SIVcpzPtt)…

  Authors: Louise V Wain, Elizabeth Bailes, Frederic Bibollet-Ruche, Julie M Decker, Brandon F Keele, Fran Van Heuverswyn, Yingying Li, Jun Takehisa, Eitel Mpoudi Ngole, George M Shaw,…

  Source: Molecular biology and evolution. 2007 Aug

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• The role of copy number variation in susceptibility to amyotrophic lateral sclerosis: genome-wide association study and comparison with published loci.

  BACKGROUND: The genetic contribution to sporadic amyotrophic lateral sclerosis (ALS) has not been fully elucidated. There are increasing efforts to ch…

  Authors: Louise V Wain, Inti Pedroso, John E Landers, Gerome Breen, Christopher E Shaw, P Nigel Leigh, Robert H Brown, Martin D Tobin, Ammar Al-Chalabi

  Source: PloS one. 2009

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• Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies.

  To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation associated with risk of ventricular arrhythmias a…

  Authors: Ilja M Nolte, Chris Wallace, Stephen J Newhouse, Daryl Waggott, Jingyuan Fu, Nicole Soranzo, Rhian Gwilliam, Panos Deloukas, Irina Savelieva, Dongling Zheng,…

  Source: PloS one. 2009

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• Chimpanzee reservoirs of pandemic and nonpandemic HIV-1.

  Human immunodeficiency virus type 1 (HIV-1), the cause of human acquired immunodeficiency syndrome (AIDS), is a zoonotic infection of staggering propo…

  Authors: Brandon F Keele, Fran Van Heuverswyn, Yingying Li, Elizabeth Bailes, Jun Takehisa, Mario L Santiago, Frederic Bibollet-Ruche, Yalu Chen, Louise V Wain, Florian Liegeois,…

  Source: Science (New York, N.Y.). 2006 Jul 28

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