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Genome-wide association studies involving hundreds of thousands of SNPs in thousands of cases and controls are now underway. The first of many analyti…
Authors: Jeffrey C Barrett, Lon R Cardon
Source: Nature genetics. 2006 Jun
View Full TextAfter nearly 10 years of intense academic and commercial research effort, large genome-wide association studies for common complex diseases are now im…
Authors: Jonathan Marchini, Peter Donnelly, Lon R Cardon
Source: Nature genetics. 2005 Apr
View Full TextGenome-wide association studies have identified hundreds of genetic variants associated with complex human diseases and traits, and have provided valu…
Authors: Teri A Manolio, Francis S Collins, Nancy J Cox, David B Goldstein, Lucia A Hindorff, David J Hunter, Mark I McCarthy, Erin M Ramos, Lon R Cardon, Aravinda Chakravarti,…
Source: Nature. 2009 Oct 8
View Full TextMuch effort and expense are being spent internationally to detect genetic polymorphisms contributing to susceptibility to complex human disease. Conco…
Authors: Lyle J Palmer, Lon R Cardon
Source: Lancet. 2005 Oct 1
View Full TextGenes in the major histocompatibility complex (MHC) encode proteins important in activating antigen-specific immune responses. Alleles at adjacent MHC…
Authors: Jon W Gregersen, Kamil R Kranc, Xiayi Ke, Pia Svendsen, Lars S Madsen, Allan Randrup Thomsen, Lon R Cardon, John I Bell, Lars Fugger
Source: Nature. 2006 Oct 5
View Full TextLarge-scale association studies hold substantial promise for unraveling the genetic basis of common human diseases. A well-known problem with such stu…
Authors: Jonathan Marchini, Lon R Cardon, Michael S Phillips, Peter Donnelly
Source: Nature genetics. 2004 May
View Full TextA substantial investment has been made in the generation of large public resources designed to enable the identification of tag SNP sets, but data est…
Authors: Eleftheria Zeggini, William Rayner, Andrew P Morris, Andrew T Hattersley, Mark Walker, Graham A Hitman, Panos Deloukas, Lon R Cardon, Mark I McCarthy
Source: Nature genetics. 2005 Dec
View Full TextGreat efforts and expense have been expended in attempts to detect genetic polymorphisms contributing to susceptibility to complex human disease. Conc…
Authors: Lon R Cardon, Lyle J Palmer
Source: Lancet. 2003 Feb 15
View Full TextLarge-scale studies of linkage disequilibrium (LD) have shown considerable variation in the extent and distribution of pairwise LD within and between …
Authors: David M Evans, Lon R Cardon
Source: American journal of human genetics. 2005 Apr
View Free Full TextSeveral risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combine…
Authors: Jeffrey C Barrett, Sarah Hansoul, Dan L Nicolae, Judy H Cho, Richard H Duerr, John D Rioux, Steven R Brant, Mark S Silverberg, Kent D Taylor, M Michael Barmada,…
Source: Nature genetics. 2008 Aug
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