1 to 10 of 77 literature results

• Evaluating coverage of genome-wide association studies.

  Genome-wide association studies involving hundreds of thousands of SNPs in thousands of cases and controls are now underway. The first of many analyti…

  Authors: Jeffrey C Barrett, Lon R Cardon

  Source: Nature genetics. 2006 Jun

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• Genome-wide strategies for detecting multiple loci that influence complex diseases.

  After nearly 10 years of intense academic and commercial research effort, large genome-wide association studies for common complex diseases are now im…

  Authors: Jonathan Marchini, Peter Donnelly, Lon R Cardon

  Source: Nature genetics. 2005 Apr

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• Finding the missing heritability of complex diseases.

  Genome-wide association studies have identified hundreds of genetic variants associated with complex human diseases and traits, and have provided valu…

  Authors: Teri A Manolio, Francis S Collins, Nancy J Cox, David B Goldstein, Lucia A Hindorff, David J Hunter, Mark I McCarthy, Erin M Ramos, Lon R Cardon, Aravinda Chakravarti,…

  Source: Nature. 2009 Oct 8

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• Shaking the tree: mapping complex disease genes with linkage disequilibrium.

  Much effort and expense are being spent internationally to detect genetic polymorphisms contributing to susceptibility to complex human disease. Conco…

  Authors: Lyle J Palmer, Lon R Cardon

  Source: Lancet. 2005 Oct 1

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• Functional epistasis on a common MHC haplotype associated with multiple sclerosis.

  Genes in the major histocompatibility complex (MHC) encode proteins important in activating antigen-specific immune responses. Alleles at adjacent MHC…

  Authors: Jon W Gregersen, Kamil R Kranc, Xiayi Ke, Pia Svendsen, Lars S Madsen, Allan Randrup Thomsen, Lon R Cardon, John I Bell, Lars Fugger

  Source: Nature. 2006 Oct 5

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• The effects of human population structure on large genetic association studies.

  Large-scale association studies hold substantial promise for unraveling the genetic basis of common human diseases. A well-known problem with such stu…

  Authors: Jonathan Marchini, Lon R Cardon, Michael S Phillips, Peter Donnelly

  Source: Nature genetics. 2004 May

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• An evaluation of HapMap sample size and tagging SNP performance in large-scale empirical and simulated data sets.

  A substantial investment has been made in the generation of large public resources designed to enable the identification of tag SNP sets, but data est…

  Authors: Eleftheria Zeggini, William Rayner, Andrew P Morris, Andrew T Hattersley, Mark Walker, Graham A Hitman, Panos Deloukas, Lon R Cardon, Mark I McCarthy

  Source: Nature genetics. 2005 Dec

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• Population stratification and spurious allelic association.

  Great efforts and expense have been expended in attempts to detect genetic polymorphisms contributing to susceptibility to complex human disease. Conc…

  Authors: Lon R Cardon, Lyle J Palmer

  Source: Lancet. 2003 Feb 15

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• A comparison of linkage disequilibrium patterns and estimated population recombination rates across multiple populations.

  Large-scale studies of linkage disequilibrium (LD) have shown considerable variation in the extent and distribution of pairwise LD within and between …

  Authors: David M Evans, Lon R Cardon

  Source: American journal of human genetics. 2005 Apr

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• Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

  Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combine…

  Authors: Jeffrey C Barrett, Sarah Hansoul, Dan L Nicolae, Judy H Cho, Richard H Duerr, John D Rioux, Steven R Brant, Mark S Silverberg, Kent D Taylor, M Michael Barmada,…

  Source: Nature genetics. 2008 Aug

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