1 to 9 of 9 literature results

• Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

  Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Stu…

  Authors: Masato Furuhashi, Gürol Tuncman, Cem Z Görgün, Liza Makowski, Genichi Atsumi, Eric Vaillancourt, Keita Kono, Vladimir R Babaev, Sergio Fazio, MacRae F Linton,…

  Source: Nature. 2007 Jun 21

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• The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis.

  PURPOSE OF REVIEW: The global prevalence of obesity is increasing epidemically. Obesity causes an array of health problems, reduces life expectancy, a…

  Authors: Liza Makowski, Gökhan S Hotamisligil

  Source: Current opinion in lipidology. 2005 Oct

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• Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice.

  BACKGROUND: The adipocyte fatty acid-binding protein (FABP) aP2 is expressed by adipocytes and macrophages and modulates insulin resistance, glucose a…

  Authors: Jeffrey B Boord, Kazuhisa Maeda, Liza Makowski, Vladimir R Babaev, Sergio Fazio, MacRae F Linton, Gökhan S Hotamisligil

  Source: Circulation. 2004 Sep 14

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• Role of the fatty acid binding protein mal1 in obesity and insulin resistance.

  The metabolic syndrome is a cluster of metabolic and inflammatory abnormalities including obesity, insulin resistance, type 2 diabetes, hypertension, …

  Authors: Kazuhisa Maeda, K Teoman Uysal, Liza Makowski, Cem Z Görgün, Genichi Atsumi, Rex A Parker, Jens Brüning, Ann Vogel Hertzel, David A Bernlohr, Gökhan S Hotamisligil

  Source: Diabetes. 2003 Feb

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• Fatty acid binding proteins--the evolutionary crossroads of inflammatory and metabolic responses.

  Fatty acid binding proteins (FABPs) are members of a highly conserved family of proteins with the task of protecting a cell's delicate lipid balance. …

  Authors: Liza Makowski, Gökhan S Hotamisligil

  Source: The Journal of nutrition. 2004 Sep

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• Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation.

  Peroxisome proliferator-activated receptor-alpha (PPARalpha) is a master transcriptional regulator of beta-oxidation and a prominent target of hypolip…

  Authors: Liza Makowski, Robert C Noland, Timothy R Koves, Weibing Xing, Olga R Ilkayeva, Michael J Muehlbauer, Robert D Stevens, Deborah M Muoio

  Source: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2009 Feb

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• The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities.

  Fatty acid-binding proteins are cytosolic fatty acid chaperones, and the adipocyte isoform, aP2, plays an important role in obesity and glucose metabo…

  Authors: Liza Makowski, Katherine C Brittingham, Joseph M Reynolds, Jill Suttles, Gökhan S Hotamisligil

  Source: The Journal of biological chemistry. 2005 Apr 1

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• Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis.

  Inflammatory processes play an important role in the pathogenesis of vascular diseases, and insulin-resistant diabetes mellitus type 2 represents an i…

  Authors: Julia Baumgartl, Stephanie Baudler, Maximilian Scherner, Vladimir Babaev, Liza Makowski, Jill Suttles, Marcia McDuffie, Kazuyuki Tobe, Takashi Kadowaki, Sergio Fazio,…

  Source: Cell metabolism. 2006 Apr

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• Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia.

  OBJECTIVE: The adipocyte fatty acid-binding protein, aP2, has important effects on insulin resistance, lipid metabolism, and atherosclerosis. Its expr…

  Authors: Jeffrey B Boord, Kazuhisa Maeda, Liza Makowski, Vladimir R Babaev, Sergio Fazio, MacRae F Linton, Gökhan S Hotamisligil

  Source: Arteriosclerosis, thrombosis, and vascular biology. 2002 Oct 1

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