1 to 8 of 8 literature results

• PPAR-gamma regulates osteoclastogenesis in mice.

  Osteoclasts are bone-resorbing cells derived from hematopoietic precursors of the monocyte-macrophage lineage. Regulation of osteoclast function is ce…

  Authors: Yihong Wan, Ling-Wa Chong, Ronald M Evans

  Source: Nature medicine. 2007 Dec

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• Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk.

  Lactation is a highly demanding lipid synthesis and transport process that is crucial for the development of newborn mammals. While PPAR gamma is know…

  Authors: Yihong Wan, Alan Saghatelian, Ling-Wa Chong, Chun-Li Zhang, Benjamin F Cravatt, Ronald M Evans

  Source: Genes & development. 2007 Aug 1

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• Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defense.

  Macrophage activation by the proinflammatory cytokine interferon-gamma (IFN-gamma) is a critical component of the host innate response to bacterial pa…

  Authors: Junichiro Sonoda, Josée Laganière, Isaac R Mehl, Grant D Barish, Ling-Wa Chong, Xiangli Li, Immo E Scheffler, Dennis C Mock, Alain R Bataille, Francois Robert,…

  Source: Genes & development. 2007 Aug 1

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• PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis.

  The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator 1beta (PGC-1beta) is believed to control mitochondrial ox…

  Authors: Junichiro Sonoda, Isaac R Mehl, Ling-Wa Chong, Russell R Nofsinger, Ronald M Evans

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2007 Mar 20

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• PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosis.

  Lipid homeostasis and inflammation are key determinants in atherogenesis, exemplified by the requirement of lipid-laden, foam cell macrophages for ath…

  Authors: Grant D Barish, Annette R Atkins, Michael Downes, Peter Olson, Ling-Wa Chong, Mike Nelson, Yuhua Zou, Hoosang Hwang, Heonjoong Kang, Linda Curtiss,…

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2008 Mar 18

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• Peroxisome proliferator-activated receptor delta promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage.

  Significant attention has focused on the role of low-density lipoprotein (LDL) in the pathogenesis of atherosclerosis. However, recent advances have i…

  Authors: Chih-Hao Lee, Kihwa Kang, Isaac R Mehl, Russell Nofsinger, William A Alaynick, Ling-Wa Chong, John M Rosenfeld, Ronald M Evans

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2006 Feb 14

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• PPARdelta regulates glucose metabolism and insulin sensitivity.

  The metabolic syndrome is a collection of obesity-related disorders. The peroxisome proliferator-activated receptors (PPARs) regulate transcription in…

  Authors: Chih-Hao Lee, Peter Olson, Andrea Hevener, Isaac Mehl, Ling-Wa Chong, Jerrold M Olefsky, Frank J Gonzalez, Jungyeob Ham, Heonjoong Kang, Jeffrey M Peters,…

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2006 Feb 28

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• Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites.

  Efficient detoxification and clearance of cholesterol metabolites such as oxysterols, bile alcohols, and bile acids are critical for survival because …

  Authors: Junichiro Sonoda, Ling Wa Chong, Michael Downes, Grant D Barish, Sally Coulter, Christopher Liddle, Chih-Hao Lee, Ronald M Evans

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2005 Feb 8

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