1 to 10 of 19 literature results

• Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1.

  Production of interleukin (IL)-10, a major immunoregulatory cytokine, by phagocytes during clearance of apoptotic cells is critical to ensuring cellul…

  Authors: Elaine Y Chung, Jianguo Liu, Yoichiro Homma, Yunhua Zhang, Andrea Brendolan, Matilde Saggese, Jihong Han, Roy Silverstein, Licia Selleri, Xiaojing Ma

  Source: Immunity. 2007 Dec

  View Free Full Text

• Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease.

  Congenital heart diseases are traditionally considered to be multifactorial in pathogenesis resulting from environmental and genetic interactions that…

  Authors: Kryn Stankunas, Ching Shang, Karen Y Twu, Shih-Chu Kao, Nancy A Jenkins, Neal G Copeland, Mrinmoy Sanyal, Licia Selleri, Michael L Cleary, Ching-Pin Chang

  Source: Circulation research. 2008 Sep 26

  View Free Full Text

• Hox cofactors in vertebrate development.

  Hox genes encode homeodomain-containing transcription factors that pattern the body axes of animal embryos. It is well established that the exquisite …

  Authors: Cecilia B Moens, Licia Selleri

  Source: Developmental biology. 2006 Mar 15

  View Full Text

• B-cell development fails in the absence of the Pbx1 proto-oncogene.

  Pbx1, a homeodomain transcription factor that was originally identified as the product of a proto-oncogene in acute pre-B-cell leukemia, is a global r…

  Authors: Mrinmoy Sanyal, James W Tung, Holger Karsunky, Hong Zeng, Licia Selleri, Irving L Weissman, Leonore A Herzenberg, Michael L Cleary

  Source: Blood. 2007 May 15

  View Free Full Text

• Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus.

  Pbx1 is a member of the TALE (three-amino acid loop extension) class of homeodomain transcription factors, which are components of hetero-oligomeric p…

  Authors: Seung K Kim, Licia Selleri, Joon S Lee, Andrew Y Zhang, Xueying Gu, Yakop Jacobs, Michael L Cleary

  Source: Nature genetics. 2002 Apr

  View Full Text

• Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome.

  The post-cranial axial skeleton consists of a metameric series of vertebral bodies and intervertebral discs, as well as adjoining ribs and sternum. Pa…

  Authors: Terence D Capellini, Rediet Zewdu, Giuseppina Di Giacomo, Stefania Asciutti, Jamie E Kugler, Anna Di Gregorio, Licia Selleri

  Source: Developmental biology. 2008 Sep 15

  View Full Text

• Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130.

  Pocket proteins and cyclin-dependent kinase (CDK) inhibitors negatively regulate cell proliferation and can promote differentiation. However, which me…

  Authors: Nancy Yeh, Jeffrey P Miller, Tripti Gaur, Terence D Capellini, Janko Nikolich-Zugich, Carmen de la Hoz, Licia Selleri, Timothy G Bromage, Andre J van Wijnen, Gary S Stein,…

  Source: Molecular and cellular biology. 2007 Jul

  View Free Full Text

• Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype.

  The interaction of Prep1 and Pbx homeodomain transcription factors regulates their activity, nuclear localization, and likely, function in development…

  Authors: Elisabetta Ferretti, J Carlos Villaescusa, Patrizia Di Rosa, Luis C Fernandez-Diaz, Elena Longobardi, Roberta Mazzieri, Annarita Miccio, Nicola Micali, Licia Selleri, Giuliana Ferrari,…

  Source: Molecular and cellular biology. 2006 Aug

  View Free Full Text

• Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development.

  Pancreatic development depends on the transcription factor Pax6, which controls islet cell differentiation and hormone production. To understand the r…

  Authors: Xin Zhang, Sheldon Rowan, Yingzi Yue, Shaun Heaney, Yi Pan, Andrea Brendolan, Licia Selleri, Richard L Maas

  Source: Developmental biology. 2006 Dec 15

  View Full Text

• Abnormalities of caudal pharyngeal pouch development in Pbx1 knockout mice mimic loss of Hox3 paralogs.

  Pbx1 is a TALE-class homeodomain protein that functions in part as a cofactor for Hox class homeodomain proteins. Previous analysis of the in vivo fun…

  Authors: Nancy R Manley, Licia Selleri, Andrea Brendolan, Julie Gordon, Michael L Cleary

  Source: Developmental biology. 2004 Dec 15

  View Full Text