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Upon encountering antigen in the context of antigen presenting cells, naïve CD4(+) T cells undergo differentiation into effector T helper (Th) cells, …
Authors: Liang Zhou, Dan R Littman
Source: Current opinion in immunology. 2009 Apr
View Free Full TextThe differentiation of naive CD4(+) T cells into lineages with distinct effector functions has been considered to be an irreversible event. T helper t…
Authors: Liang Zhou, Mark M W Chong, Dan R Littman
Source: Immunity. 2009 May
View Full TextT helper cells that produce interleukin 17 (IL-17; 'T(H)-17 cells') are a distinct subset of proinflammatory cells whose in vivo function requires IL-…
Authors: Liang Zhou, Ivaylo I Ivanov, Rosanne Spolski, Roy Min, Kevin Shenderov, Takeshi Egawa, David E Levy, Warren J Leonard, Dan R Littman
Source: Nature immunology. 2007 Sep
View Full TextT helper cells that produce IL-17 (T(H)17 cells) promote autoimmunity in mice and have been implicated in the pathogenesis of human inflammatory disea…
Authors: Liang Zhou, Jared E Lopes, Mark M W Chong, Ivaylo I Ivanov, Roy Min, Gabriel D Victora, Yuelei Shen, Jianguang Du, Yuri P Rubtsov, Alexander Y Rudensky,…
Source: Nature. 2008 May 8
View Free Full TextIL-17-producing T lymphocytes have been recently shown to comprise a distinct lineage of proinflammatory T helper cells, termed Th17 cells, that are m…
Authors: Ivaylo I Ivanov, Brent S McKenzie, Liang Zhou, Carlos E Tadokoro, Alice Lepelley, Juan J Lafaille, Daniel J Cua, Dan R Littman
Source: Cell. 2006 Sep 22
View Full TextAuthors: Aaron J Martin, Liang Zhou, Stephen D Miller
Source: Nature immunology. 2009 Dec
View Full TextThe NF-kappaB family members p65 (RelA) and c-Rel recognize similar DNA sequences, yet the phenotypes of mutant mice suggest that these proteins regul…
Authors: Shomyseh Sanjabi, Kevin J Williams, Simona Saccani, Liang Zhou, Alexander Hoffmann, Gourisankar Ghosh, Steve Gerondakis, Gioacchino Natoli, Stephen T Smale
Source: Genes & development. 2005 Sep 15
View Free Full TextThe paradigm of effector T helper cell differentiation into either Th1 or Th2 lineages has been profoundly shaken by the discovery of T cells that sec…
Authors: Ivaylo I Ivanov, Liang Zhou, Dan R Littman
Source: Seminars in immunology. 2007 Dec
View Free Full TextAortic dissection is an age-dependent life-threatening cardiovascular disease with high mortality rates. Recent research has shown that inflammation p…
Authors: Fang Luo, Xian-Liang Zhou, Jian-Jun Li, Ru-Tai Hui
Source: Ageing research reviews. 2009 Jan
View Full TextInterleukin-12 (IL-12) and IL-23 are heterodimeric cytokines that serve as critical regulators of T helper cell development. The Il12b gene, which enc…
Authors: Liang Zhou, Aaron A Nazarian, Jian Xu, Dean Tantin, Lynn M Corcoran, Stephen T Smale
Source: Molecular and cellular biology. 2007 Apr
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