1 to 10 of 268 literature results

• Transcriptional regulatory networks in Th17 cell differentiation.

  Upon encountering antigen in the context of antigen presenting cells, naïve CD4(+) T cells undergo differentiation into effector T helper (Th) cells, …

  Authors: Liang Zhou, Dan R Littman

  Source: Current opinion in immunology. 2009 Apr

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• Plasticity of CD4+ T cell lineage differentiation.

  The differentiation of naive CD4(+) T cells into lineages with distinct effector functions has been considered to be an irreversible event. T helper t…

  Authors: Liang Zhou, Mark M W Chong, Dan R Littman

  Source: Immunity. 2009 May

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• IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways.

  T helper cells that produce interleukin 17 (IL-17; 'T(H)-17 cells') are a distinct subset of proinflammatory cells whose in vivo function requires IL-…

  Authors: Liang Zhou, Ivaylo I Ivanov, Rosanne Spolski, Roy Min, Kevin Shenderov, Takeshi Egawa, David E Levy, Warren J Leonard, Dan R Littman

  Source: Nature immunology. 2007 Sep

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• TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function.

  T helper cells that produce IL-17 (T(H)17 cells) promote autoimmunity in mice and have been implicated in the pathogenesis of human inflammatory disea…

  Authors: Liang Zhou, Jared E Lopes, Mark M W Chong, Ivaylo I Ivanov, Roy Min, Gabriel D Victora, Yuelei Shen, Jianguang Du, Yuri P Rubtsov, Alexander Y Rudensky,…

  Source: Nature. 2008 May 8

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• The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.

  IL-17-producing T lymphocytes have been recently shown to comprise a distinct lineage of proinflammatory T helper cells, termed Th17 cells, that are m…

  Authors: Ivaylo I Ivanov, Brent S McKenzie, Liang Zhou, Carlos E Tadokoro, Alice Lepelley, Juan J Lafaille, Daniel J Cua, Dan R Littman

  Source: Cell. 2006 Sep 22

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• MicroRNA--managing the TH-17 inflammatory response.

  Authors: Aaron J Martin, Liang Zhou, Stephen D Miller

  Source: Nature immunology. 2009 Dec

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• A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation.

  The NF-kappaB family members p65 (RelA) and c-Rel recognize similar DNA sequences, yet the phenotypes of mutant mice suggest that these proteins regul…

  Authors: Shomyseh Sanjabi, Kevin J Williams, Simona Saccani, Liang Zhou, Alexander Hoffmann, Gourisankar Ghosh, Steve Gerondakis, Gioacchino Natoli, Stephen T Smale

  Source: Genes & development. 2005 Sep 15

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• Transcriptional regulation of Th17 cell differentiation.

  The paradigm of effector T helper cell differentiation into either Th1 or Th2 lineages has been profoundly shaken by the discovery of T cells that sec…

  Authors: Ivaylo I Ivanov, Liang Zhou, Dan R Littman

  Source: Seminars in immunology. 2007 Dec

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• Inflammatory response is associated with aortic dissection.

  Aortic dissection is an age-dependent life-threatening cardiovascular disease with high mortality rates. Recent research has shown that inflammation p…

  Authors: Fang Luo, Xian-Liang Zhou, Jian-Jun Li, Ru-Tai Hui

  Source: Ageing research reviews. 2009 Jan

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• An inducible enhancer required for Il12b promoter activity in an insulated chromatin environment.

  Interleukin-12 (IL-12) and IL-23 are heterodimeric cytokines that serve as critical regulators of T helper cell development. The Il12b gene, which enc…

  Authors: Liang Zhou, Aaron A Nazarian, Jian Xu, Dean Tantin, Lynn M Corcoran, Stephen T Smale

  Source: Molecular and cellular biology. 2007 Apr

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