1 to 10 of 584 literature results

• Tumour invasion and metastasis initiated by microRNA-10b in breast cancer.

  MicroRNAs have been implicated in regulating diverse cellular pathways. Although there is emerging evidence that some microRNAs can function as oncoge…

  Authors: Li Ma, Julie Teruya-Feldstein, Robert A Weinberg

  Source: Nature. 2007 Oct 11

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• Essential autocrine regulation by IL-21 in the generation of inflammatory T cells.

  After activation, CD4+ helper T (T(H)) cells differentiate into distinct effector subsets that are characterized by their unique cytokine expression a…

  Authors: Roza Nurieva, Xuexian O Yang, Gustavo Martinez, Yongliang Zhang, Athanasia D Panopoulos, Li Ma, Kimberly Schluns, Qiang Tian, Stephanie S Watowich, Anton M Jetten,…

  Source: Nature. 2007 Jul 26

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• Requirement for Nudel and dynein for assembly of the lamin B spindle matrix.

  The small guanosine triphosphatase Ran loaded with GTP (RanGTP) can stimulate assembly of the type V intermediate filament protein lamin B into a memb…

  Authors: Li Ma, Ming-Ying Tsai, Shusheng Wang, Bingwen Lu, Rong Chen, John R Yates Iii, Xueliang Zhu, Yixian Zheng

  Source: Nature cell biology. 2009 Mar

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• miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis.

  MicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of cancer. Here we show that miR-9, which is upregulated in bre…

  Authors: Li Ma, Jennifer Young, Harsha Prabhala, Elizabeth Pan, Pieter Mestdagh, Daniel Muth, Julie Teruya-Feldstein, Ferenc Reinhardt, Tamer T Onder, Scott Valastyan,…

  Source: Nature cell biology. 2010 Mar

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• Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease.

  By analyzing late-onset Alzheimer's disease (LOAD) in a genome-wide association study (313,504 SNPs, three series, 844 cases and 1,255 controls) and e…

  Authors: Minerva M Carrasquillo, Fanggeng Zou, V Shane Pankratz, Samantha L Wilcox, Li Ma, Louise P Walker, Samuel G Younkin, Curtis S Younkin, Linda H Younkin, Gina D Bisceglio,…

  Source: Nature genetics. 2009 Feb

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• Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis.

  Tuberous sclerosis (TSC) is a tumor syndrome caused by mutation in TSC1 or TSC2 genes. TSC tumorigenesis is not always accompanied by loss of heterozy…

  Authors: Li Ma, Zhenbang Chen, Hediye Erdjument-Bromage, Paul Tempst, Pier Paolo Pandolfi

  Source: Cell. 2005 Apr 22

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• The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas.

  We analyzed the PI3K-AKT signaling cascade in a cohort of sarcomas and found a marked induction of insulin receptor substrate-2 (IRS2) and phosphoryla…

  Authors: Eva Hernando, Elizabeth Charytonowicz, Maria E Dudas, Silvia Menendez, Igor Matushansky, Joslyn Mills, Nicholas D Socci, Nille Behrendt, Li Ma, Robert G Maki,…

  Source: Nature medicine. 2007 Jun

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• Critical regulation of early Th17 cell differentiation by interleukin-1 signaling.

  T helper (Th) 17 cells have been recently discovered in both mouse and human. Here we show that interleukin-1 (IL-1) signaling on T cells is criticall…

  Authors: Yeonseok Chung, Seon Hee Chang, Gustavo J Martinez, Xuexian O Yang, Roza Nurieva, Hong Soon Kang, Li Ma, Stephanie S Watowich, Anton M Jetten, Qiang Tian,…

  Source: Immunity. 2009 Apr 17

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• The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis.

  The mammalian target of rapamycin, mTOR, regulates cell growth and proliferation. Here we show that the initiation factor of translation (eIF-4E), a d…

  Authors: Davide Ruggero, Lorenzo Montanaro, Li Ma, Wei Xu, Paola Londei, Carlos Cordon-Cardo, Pier Paolo Pandolfi

  Source: Nature medicine. 2004 May

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• Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages.

  After activation, CD4(+) helper T (Th) cells differentiate into distinct effector subsets. Although chemokine (C-X-C motif) receptor 5-expressing T fo…

  Authors: Roza I Nurieva, Yeonseok Chung, Daehee Hwang, Xuexian O Yang, Hong Soon Kang, Li Ma, Yi-hong Wang, Stephanie S Watowich, Anton M Jetten, Qiang Tian,…

  Source: Immunity. 2008 Jul 18

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