1 to 10 of 75 literature results

• Germ cell tumors in the intersex gonad: old paths, new directions, moving frontiers.

  The risk for the development of germ cell tumors is an important factor to deal with in the management of patients with disorders of sex development (…

  Authors: Martine Cools, Stenvert L S Drop, Katja P Wolffenbuttel, J Wolter Oosterhuis, Leendert H J Looijenga

  Source: Endocrine reviews. 2006 Aug

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• A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.

  Endogenous small RNAs (miRNAs) regulate gene expression by mechanisms conserved across metazoans. While the number of verified human miRNAs is still e…

  Authors: P Mathijs Voorhoeve, Carlos le Sage, Mariette Schrier, Ad J M Gillis, Hans Stoop, Remco Nagel, Ying-Poi Liu, Josyanne van Duijse, Jarno Drost, Alexander Griekspoor,…

  Source: Cell. 2006 Mar 24

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• CD30 is a survival factor and a biomarker for transformed human pluripotent stem cells.

  The application of human embryonic stem (hES) cells in regenerative medicine will require rigorous quality control measures to ensure the safety of hE…

  Authors: Daniella Herszfeld, Ernst Wolvetang, Emma Langton-Bunker, Tung-Liang Chung, Adam A Filipczyk, Souheir Houssami, Pegah Jamshidi, Karen Koh, Andrew L Laslett, Anna Michalska,…

  Source: Nature biotechnology. 2006 Mar

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• Cord blood for tissue regeneration.

  Umbilical cord blood (CB) has become a commonly accepted source of hematopoietic stem cells for transplantation in children and adults. It is readily …

  Authors: Anja Buchheiser, Stefanie Liedtke, Leendert H J Looijenga, Gesine Kögler

  Source: Journal of cellular biochemistry. 2009 Nov 1

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• Lung cancer: intragenic ERBB2 kinase mutations in tumours.

  The protein-kinase family is the most frequently mutated gene family found in human cancer and faulty kinase enzymes are being investigated as promisi…

  Authors: Philip Stephens, Chris Hunter, Graham Bignell, Sarah Edkins, Helen Davies, Jon Teague, Claire Stevens, Sarah O'Meara, Raffaella Smith, Adrian Parker,…

  Source: Nature. 2004 Sep 30

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• Clinical value of the X chromosome in testicular germ-cell tumours.

  Authors: Leendert H J Looijenga, J Wolter Oosterhuis

  Source: Lancet. 2004 Jan 3

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• A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.

  We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no s…

  Authors: Philip Stephens, Sarah Edkins, Helen Davies, Chris Greenman, Charles Cox, Chris Hunter, Graham Bignell, Jon Teague, Raffaella Smith, Claire Stevens,…

  Source: Nature genetics. 2005 Jun

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• Critical function of AP-2 gamma/TCFAP2C in mouse embryonic germ cell maintenance.

  Formation of the germ cell lineage involves multiple processes, including repression of somatic differentiation and reacquisition of pluripotency as w…

  Authors: Susanne Weber, Dawid Eckert, Daniel Nettersheim, Ad J M Gillis, Sabine Schäfer, Peter Kuckenberg, Julia Ehlermann, Uwe Werling, Katharina Biermann, Leendert H J Looijenga,…

  Source: Biology of reproduction. 2010 Jan

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• Comparative proteome, transcriptome, and genome analysis of a gonadal and an extragonadal germ cell tumor cell line.

  Whereas clinical differences between testicular and extragonadal germ cell tumors (GCT), like reduced cisplatin sensitivity of extragonadal tumors, ar…

  Authors: Stephanie Glaesener, Friedemann Honecker, Imke M Veltman, Ad J M Gillis, Tina Rohlfing, Thomas Streichert, Benjamin Otto, Tim H Brummendorf, Leendert H J Looijenga, Carsten Bokemeyer,…

  Source: Journal of proteome research. 2008 Sep

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• Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25).

  Recently, we identified a patient with an infantile sacrococcygeal teratoma and a constitutional t(12;15)(q13;q25). Here, we show that, as a result of…

  Authors: Imke M Veltman, Lilian A Vreede, Jinke Cheng, Leendert H J Looijenga, Bert Janssen, Eric F P M Schoenmakers, Edward T H Yeh, Ad Geurts van Kessel

  Source: Human molecular genetics. 2005 Jul 15

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