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• A Drosophila model to identify polyamine-drug conjugates that target the polyamine transporter in an intact epithelium.

  Polyamine transport is elevated in many tumor types, suggesting that toxic polyamine-drug conjugates could be targeted to cancer cells via the polyami…

  Authors: Chung Tsen, Mark Iltis, Navneet Kaur, Cynthia Bayer, Jean-Guy Delcros, Laurence von Kalm, Otto Phanstiel

  Source: Journal of medicinal chemistry. 2008 Jan 24

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• Genetic interactions between the RhoA and Stubble-stubbloid loci suggest a role for a type II transmembrane serine protease in intracellular signaling during Drosophila imaginal disc morphogenesis.

  The Drosophila RhoA (Rho1) GTPase is essential for postembryonic morphogenesis of leg and wing imaginal discs. Mutations in RhoA enhance leg and wing …

  Authors: Cynthia A Bayer, Susan R Halsell, James W Fristrom, Daniel P Kiehart, Laurence von Kalm

  Source: Genetics. 2003 Nov

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• Evolution of the Drosophila broad locus: the Manduca sexta broad Z4 isoform has biological activity in Drosophila.

  The Drosophila melanogaster broad locus is essential for normal metamorphic development. Broad encodes three genetically distinct functions (rbp, br, …

  Authors: Cynthia Bayer, Xiaofeng Zhou, Baohua Zhou, Lynn M Riddiford, Laurence von Kalm

  Source: Development genes and evolution. 2003 Oct

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